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Expansion of the MAPP Research Network: Microbial and Biopsychosocial Contributio

Award Number: U01DK103271
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): Dr. Nickel and his collaborative research network have undertaken numerous etiology, epidemiology, diagnostic, and treatment studies in the field of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and interstitial cystitis/bladder pain syndrome (IC/BPS) referred to collectively as Urologic Chronic Pelvic Pain Syndrome (UCPPS). He and his research group have participated in the NIH funded CPCRN (1 and 2), ICTTG and ICCRN collaborative research networks evaluating CP/CPPS and IC/BPS respectively and Dr. Nickel was the Project Leader for the first Trans-MAPP Infection Etiology Study. Based on this experience, we hypothesize that symptom severity, impact and patterns (including flares) in defined patient phenotypes are associated with very heterogeneous patient-specific urinary microbial or microbiome patterns (or changes) as well as (partner) factors, other psychological parameters (depression, catastrophizing, illness perception), sleep, sexual status, and environment factors (diet, perceived stress, exercise). Our aim (Aim 1) is the enhance the proposed trans-MAPP Symptom Pattern Study by becoming an active Discovery Site, employing our expertise and experience to assist in patient enrollment (particularly difficult to enroll patient subtypes) as well as to suggest clinical, physical, urological and psychosocial assessment and outcome tools for predictive phenotype identification. We further plan (Aim 2) to expand our initial and ongoing trans-MAPP Infection Etiology Project (using state of the art culture independent technology) to determine the clinical implications and impact of the microbiome of the lower urinary tract on symptoms (symptom phenotype) and changing symptom patterns (including flares) in patients with UCPPS enrolled in the trans-MAPP Symptom Pattern Study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$125,850 )
2021	2018	QUEEN'S UNIVERSITY AT KINGSTON	99 UNIVERSITY AVE	KINGSTON	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	4/2/2021	NON-COMPETING CONTINUATION	-$125,850


Issue Date FY: 2018 ( Subtotal = $236,048 )
2018	2018	QUEEN'S UNIVERSITY AT KINGSTON	99 UNIVERSITY AVE	KINGSTON	ON	K7L 3N5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/10/2018	NON-COMPETING CONTINUATION	$236,048


Issue Date FY: 2017 ( Subtotal = $233,333 )
2017	2017	QUEEN'S UNIVERSITY AT KINGSTON	99 UNIVERSITY AVE	KINGSTON	ON	K7L 3N5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/26/2017	NON-COMPETING CONTINUATION	$233,333


Issue Date FY: 2016 ( Subtotal = $233,407 )
2016	2016	QUEEN`S UNIVERSITY KINGSTON	62 ARCH STREET	KINGSTON				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/7/2016	NON-COMPETING CONTINUATION	$233,407


Issue Date FY: 2015 ( Subtotal = $233,333 )
2015	2015	QUEEN`S UNIVERSITY KINGSTON	62 ARCH STREET	KINGSTON				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/20/2015	NON-COMPETING CONTINUATION	$233,333


Issue Date FY: 2014 ( Subtotal = $233,333 )
2014	2014	QUEEN`S UNIVERSITY KINGSTON	62 ARCH STREET	KINGSTON				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/12/2014	NEW	$233,333


Grand Total All Awards = $1,043,604

Sum of Action Amount is $1,043,604;

Grand Total = $1,043,604

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Expansion of the MAPP Research Network: Microbial and Biopsychosocial Contributio

Award Number: U01DK103271

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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