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Understanding Cholestatic Disorders in a Collaborative Network: The Role of SickK

Award Number: U01DK103135
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): Pediatric liver disease is rare but can lead to other morbidities, organ transplantation, or even death. The Childhood Liver Disease Research Network (ChiLDReN) is a collaborative network dedicated to research endeavors related to eight pediatric liver diseases, namely biliary atresia (BA); Alagille syndrome (ALGS); alpha-1-antitrypsin deficiency; progressive familial intrahepatic cholestasis (PFIC); bile acid synthesis defects; mitochondrial hepatopathies; idiopathic neonatal hepatitis; and cystic fibrosis liver disease. ChiLDReN aims to promote clinical and translational research on pediatric liver diseases in hopes of elucidating the pathogenesis and natural history, and developing means of treatment and clinical management. The Network will continue to build its robust biorepository of plasma, serum, urine, DNA, and hepatobiliary tissue specimens for use in future studies and analyses. It will also continue to compile already considerable datasets on demographic, medical history, and neurocognitive characteristics of pediatric liver disease. The Network has also recently initiated a clinical trial to address key gaps in the early management of children with biliary atresia, and is on the brink of initiating several other trials, which will facilitate treatment options for children with rare liver disease. Our site aims to contribute to the goals of ChiLDReN by ensuring continued and future availability of patients for observational and interventional Network protocols. We will also continue to the intellectual needs of the Network by providing committee leadership within the consortium, actively participating in data analysis and manuscript development, and developing novel studies and protocols. To this effect, we propose a novel and exciting protocol to differentiate cholangiocytes from induced pluripotent cells, and to apply this technology to model several biliary diseases of direct relevance to the Network. Through the continuation of its longitudinal observational and interventional studies, ChiLDReN aims to discover new diagnostics, etiologies, and treatment options for children with rare liver disease and those who undergo liver transplantation. The findings from the studies and analyses conducted by ChiLDReN will ultimately help improve outcomes and quality of life for North American children who suffer from liver disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $37,033 )
2023	2018	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	12/1/2022	NON-COMPETING CONTINUATION	$37,033
2023	2018	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	12/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $37,033

Issue Date FY: 2021 ( Subtotal = -$37,033 )
2021	2018	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/29/2021	NON-COMPETING CONTINUATION	-$37,033
														Subtotal = -$37,033

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	9/25/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $248,916 )
2018	2018	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/2/2018	NON-COMPETING CONTINUATION	$248,916
														Subtotal = $248,916

Issue Date FY: 2017 ( Subtotal = $207,336 )
2017	2017	HOSPITAL FOR SICK CHILDREN, THE	555 UNIVERSITY AVE	TORONTO	ON	M5G 1X8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/22/2017	NON-COMPETING CONTINUATION	$207,336
														Subtotal = $207,336

Issue Date FY: 2016 ( Subtotal = $200,091 )
2016	2016	HOSPITAL FOR SICK CHILDREN, TORONTO	555 UNIVERSITY AVENUE	TORONTO, ONTARIO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/13/2016	NON-COMPETING CONTINUATION	$200,091
														Subtotal = $200,091

Issue Date FY: 2015 ( Subtotal = $187,299 )
2015	2015	HOSPITAL FOR SICK CHILDREN, TORONTO	555 UNIVERSITY AVENUE	TORONTO, ONTARIO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	8/4/2015	NON-COMPETING CONTINUATION	$187,299
														Subtotal = $187,299

Issue Date FY: 2014 ( Subtotal = $172,992 )
2014	2014	HOSPITAL FOR SICK CHILDREN, TORONTO	555 UNIVERSITY AVENUE	TORONTO, ONTARIO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/6/2014	NEW	$172,992
														Subtotal = $172,992

Grand Total All Awards = $1,016,634

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Understanding Cholestatic Disorders in a Collaborative Network: The Role of SickK

Award Number: U01DK103135

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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