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3D Neural Connection and Visceral Pain Receptor Atlas for Genitourinary Tract Dev

Award Number: U01DK101037
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): The NIDDK has funded a program to develop a comprehensive understanding of how nociceptive or pain receptor systems develop in the mouse embryo and mature in the adult. This basic understanding will provide a foundation for pre-clinical and clinical research into chronic pelvic pain and similar health conditions, which affect 1-6% of women and 1-3% of men. This project will capture three-dimensional images of the developing nervous systems relating to pain in the mouse embryo. We will use molecular biology techniques to visualize the developing neurons in a range of colors that can be captured using a confocal microscope. To capture a full image of the embryo region at the resolution needed to see individual nerve fibers (about 1 thousandth of a millimeter) we will use a new Mesoscope microscope invented in the UK, which can scan the whole embryo non-destructively. The resulting images will provide a massive volume of data and information to be mined for cellular detail. We will deliver the image data to the research community and public via web-browser based viewers that allow the researcher to view any part of the volume at full resolution. The data will be freely accessible to the public and can be downloaded for further research. We will capture a time-series of these 3D images to build for the first time a detailed but complete view of the development of the pain receptor and sensory systems in mammals. The information about the developing nerves will be held in a database linked to the NIH/NIDDK funded Genitourinary Molecular Anatomy Project (GUDMAP) database.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	UNIVERSITY OF EDINBURGH	1-7 ROXBURGH STREET	EDINBURGH				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	10/29/2014	NEW	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $223,333 )
2013	2013	UNIVERSITY OF EDINBURGH	OLD COLLEGE, SOUTH BRIDGE	EDINBURGH				GBR	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/20/2013	NEW	$223,333
														Subtotal = $223,333

Grand Total All Awards = $223,333

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3D Neural Connection and Visceral Pain Receptor Atlas for Genitourinary Tract Dev

Award Number: U01DK101037

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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