Tuesday, August 19, 2025 8/19/2025

CUREGN 3.0 - Pediatric Nephrology Consortium - PCC

Award Number: U01DK100866
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2013
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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CUREGN 3.0 - Pediatric Nephrology Consortium - PCC - Abstract Primary glomerular diseases, including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), immunoglobulin A nephropathy (IgAN), and membranous nephropathy (MN), are associated with significant morbidity and mortality in both adults and children. Cure Glomerulonephropathy (CureGN) is a prospective, longitudinal observational cohort study launched in 2013 to address critical knowledge gaps in the pathogenesis, natural history, and response to therapy of these heterogeneous disorders. It is a study of unprecedented size and remarkable depth, built by a unique collaborative interdisciplinary community. The international consortium includes researchers with diverse expertise, affected patients and advocacy groups, the biopharmaceutical industry, and federal funding agencies. CureGN has successfully recruited a diverse cohort of nearly 2800 adult and pediatric participants with MCD, FSGS, IgAN and MN from more than 60 clinical study sites. Biospecimens, clinical data, and patient reported outcomes are collected to enable high- quality clinical, mechanistic, and translational investigations. This foundational work is being conducted by a collaborative infrastructure including the Data Coordinating Center (at the University of Michigan, Northwestern University and Cleveland Clinic) and four Participating Clinical Centers (managed at the University of Pennsylvania, Columbia University, University of North Carolina, and the Pediatric Nephrology Research Consortium). CureGN is paving the way for personalized care in glomerular disease by disentangling the heterogeneity within these disorders that are etiologically diverse but currently grouped into only four diagnoses. In CureGN’s third study phase, we propose to maintain and enhance the CureGN Consortium infrastructure and ancillary studies program to accelerate patient-relevant glomerular disease research. We will continue our core observational study, enrolling additional participants in a recruit-to-replace strategy to maintain an active cohort of 2000 participants with high quality clinical data and biospecimens. We will implement state of the art tools for remote data and biospecimen collection, expand biospecimen types, and implement the use of new mobile applications for patient engagement and medical record linkages. Mature scientific working groups, committees and ancillary infrastructure will continue to support a multidisciplinary core and ancillary study program to achieve the scientific goals of CureGN. We will continue our outreach to the scientific community by enhancing CureGN’s role as an outstanding training vehicle for the next generation of glomerular disease researchers and attracting cutting-edge, established scientists to glomerular disease through opportunity pool grants, collaborations with patient advocacy groups and professional societies, training workshops and support of ancillary studies from academic and industry partners. Through this coordinated effort, CureGN is prepared to accelerate improvements in the care of patients with glomerular disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $953,728 )
2025	2025	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	13	8/5/2025	NON-COMPETING CONTINUATION	$953,728
2025	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	11/4/2024	COMPETING CONTINUATION	$156,580
2025	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	11/4/2024	NON-COMPETING CONTINUATION	-$156,580
														Subtotal = $953,728

Issue Date FY: 2024 ( Subtotal = $925,000 )
2024	2024	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	8/14/2024	COMPETING CONTINUATION	$925,000
2024	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	3/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $925,000

Issue Date FY: 2023 ( Subtotal = $1,083,678 )
2023	2023	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	6/9/2023	NON-COMPETING CONTINUATION	$1,083,678
														Subtotal = $1,083,678

Issue Date FY: 2022 ( Subtotal = $747,864 )
2022	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	10	7/6/2022	NON-COMPETING CONTINUATION	$0
2022	2022	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	6/29/2022	NON-COMPETING CONTINUATION	$747,864
2022	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	3/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $747,864

Issue Date FY: 2021 ( Subtotal = $811,294 )
2021	2021	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	5/27/2021	NON-COMPETING CONTINUATION	$811,294
2021	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	12/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $811,294

Issue Date FY: 2020 ( Subtotal = $1,083,678 )
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	5/18/2020	NON-COMPETING CONTINUATION	$1,083,678
2020	2020	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	8	8/17/2020	NON-COMPETING CONTINUATION	$0
2020	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	11/27/2019	COMPETING CONTINUATION	$0
														Subtotal = $1,083,678

Issue Date FY: 2019 ( Subtotal = $1,864,919 )
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	9/26/2019	COMPETING CONTINUATION	$683,520
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/14/2019	COMPETING CONTINUATION	$1,083,678
2019	2019	RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL	700 CHILDRENS DR	COLUMBUS	OH	43205	FRANKLIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	9/16/2019	COMPETING CONTINUATION	$97,721
														Subtotal = $1,864,919

Grand Total All Awards = $7,470,161

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CUREGN 3.0 - Pediatric Nephrology Consortium - PCC

Award Number: U01DK100866

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2013

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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