Thursday, November 21, 2024 11/21/2024

Characterization of cellular and molecular components of intestinal niche

Award Number: U01DK085507
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Characterized by rapid and continual turnover, the intestine provides an elegant system for the study of cells which self-renew and regenerate, and thus hold great promise for regenerative medicine. Studies have provided important insight regarding the capacity of intestinal stem cells for self-repair or healing as well as ongoing maintenance and differentiation into all the various intestinal cell types. However, considerable research is needed to better understand how to treat intestinal disorders. Many intestinal disorders are due to defects in the stem cells or progenitor cells (which are more specific than stem cells) or to misdirected signals provided by the niche, the microenvironment which helps to regulate stem and progenitor cell behavior. Defining the essential cellular niche components and the associated key signals that direct stem and progenitor cells to proliferate and differentiate will be an innovative and important step toward treating intestinal disorders with regenerative medicine. The overall mission of the Intestinal Stem Cell Consortium (ISCC) is to characterize the niche components that support intestinal stem cells in health and disease, using an integrated, multidisciplinary team science approach, with the vision of developing novel therapies targeting intestinal stem cells and supportive niche to regenerate and rebuild the human intestine. To achieve the ultimate goals of pre-clinical development of both humoral and tissue therapy, the research project proposed herein will contribute with the following specific aims: to characterize cellular components and molecular signals of the intestinal niche network under both homeostasis and stress conditions, and to define these in the mouse model to provide an insight into human organoid growth. Methods to be used include bulk and single cell RNA-seq analyses, RNA-scope, 3D immunofluorescent imaging, and 3D organoid culture.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH ST	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	7/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $412,500 )
2023	2023	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH ST	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	8/18/2023	NON-COMPETING CONTINUATION	$412,500
														Subtotal = $412,500

Issue Date FY: 2022 ( Subtotal = $443,875 )
2022	2022	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH ST	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	14	9/12/2022	SUPPLEMENT FOR EXPANSION	$31,375
2022	2022	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH ST	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	14	9/1/2022	NON-COMPETING CONTINUATION	$412,500
2022	2021	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH ST	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	6/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $443,875

Issue Date FY: 2021 ( Subtotal = $412,500 )
2021	2021	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	8/16/2021	NON-COMPETING CONTINUATION	$412,500
														Subtotal = $412,500

Issue Date FY: 2020 ( Subtotal = $412,500 )
2020	2020	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	8/13/2020	NON-COMPETING CONTINUATION	$412,500
2020	2019	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	2/25/2020	COMPETING CONTINUATION	$4,964
2020	2018	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/25/2020	SUPPLEMENT FOR EXPANSION	-$4,964
														Subtotal = $412,500

Issue Date FY: 2019 ( Subtotal = $412,500 )
2019	2019	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	9/10/2019	COMPETING CONTINUATION	$412,500
														Subtotal = $412,500

Issue Date FY: 2018 ( Subtotal = $446,333 )
2018	2018	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	8/14/2018	SUPPLEMENT FOR EXPANSION	$81,840
2018	2018	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	8/13/2018	NON-COMPETING CONTINUATION	$364,493
														Subtotal = $446,333

Issue Date FY: 2017 ( Subtotal = $447,488 )
2017	2017	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	8/23/2017	SUPPLEMENT FOR EXPANSION	$82,995
2017	2017	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 E 50TH	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	8/22/2017	NON-COMPETING CONTINUATION	$364,493
														Subtotal = $447,488

Issue Date FY: 2016 ( Subtotal = $446,993 )
2016	2016	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	9/9/2016	SUPPLEMENT FOR EXPANSION	$82,500
2016	2016	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	8/16/2016	NON-COMPETING CONTINUATION	$364,493
														Subtotal = $446,993

Issue Date FY: 2015 ( Subtotal = $422,375 )
2015	2015	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	9/7/2015	SUPPLEMENT FOR EXPANSION	$57,882
2015	2015	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/28/2015	NON-COMPETING CONTINUATION	$364,493
														Subtotal = $422,375

Issue Date FY: 2014 ( Subtotal = $364,493 )
2014	2014	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	8/27/2014	COMPETING CONTINUATION	$364,493
														Subtotal = $364,493

Issue Date FY: 2013 ( Subtotal = $432,679 )
2013	2013	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	8/26/2013	SUPPLEMENT FOR EXPANSION	$87,450
2013	2013	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/20/2013	NON-COMPETING CONTINUATION	$345,229
														Subtotal = $432,679

Issue Date FY: 2012 ( Subtotal = $463,050 )
2012	2012	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/18/2012	SUPPLEMENT FOR EXPANSION	$105,300
2012	2012	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	8/23/2012	NON-COMPETING CONTINUATION	$357,750
														Subtotal = $463,050

Issue Date FY: 2011 ( Subtotal = $357,750 )
2011	2011	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/13/2011	EXTENSION WITH OR WITHOUT FUNDS	$357,750
														Subtotal = $357,750

Issue Date FY: 2010 ( Subtotal = $357,750 )
2010	2010	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Trans-NIH Recovery Act Research Support	001	2	8/19/2010	NON-COMPETING CONTINUATION	$357,750
2010	2009	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Trans-NIH Recovery Act Research Support	000	1	8/18/2010	NEW	$0
														Subtotal = $357,750

Issue Date FY: 2009 ( Subtotal = $357,750 )
2009	2009	STOWERS INSTITUTE FOR MEDICAL RESEARCH	1000 EAST 50TH STREET	KANSAS CITY	MO	64110	JACKSON	USA	Trans-NIH Recovery Act Research Support	000	1	9/16/2009	NEW	$357,750
														Subtotal = $357,750

Grand Total All Awards = $6,190,536

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Characterization of cellular and molecular components of intestinal niche

Award Number: U01DK085507

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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