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Limited Competition for the Continuation of the Childhood Liver Disease Research Network (ChilLDRen) Clinical Centers.

Award Number: U01DK084538
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Limited Competition for the Continuation of the Childhood Liver Disease Research Network (ChilLDRen) Clinical Centers. - Albeit each is relatively rare, congenital cholestatic liver diseases collectively impact pediatric health significantly. Amongst them, biliary atresia (BA) is the most common cause of pediatric end-stage liver disease and the leading indication for pediatric liver transplantation. The Childhood Liver Disease Research Network (ChiLDReN) was established in 2009 to expand the scope of the Biliary Atresia Research Consortium to study numerous rare congenital cholestatic liver diseases including Alagille syndrome, Progressive Familial Intrahepatic Cholestasis, a1- Antitrypsin Deficiency, Mitochodrial Hepatopathies, and Bile Salt Synthesis Defects. Since then, numerous high impact observations have been reported by the NIDDK-funded consortium. Primary Sclerosing Cholangitis is currently being added as a disease of focus by the network. The Children’s Hospital Los Angeles (CHLA) clinical research center has been very active in all aspects of the network’s efforts. In this application, we restate our commitment to improve the clinical outcomes of patients with congenital liver diseases. The overall objectives of this application are to impact survival of children with rare liver diseases via (1) the enrollment of subjects into the various clinical studies and trials within the ChiLDREN consortium and (2) a translational ancillary study focused on CoQ10, as a biomarker of liver fibrosis. The central hypothesis of objective #2 is that serum levels of CoQ10 correlate with extent of liver fibrosis. This project is innovative because (1) CHLA has the only Principal Investigator who is a pediatric surgeon, thus providing surgical insight and perspective for a Steering Committee otherwise comprised of pediatric hepatologists and (2) CoQ10 is a novel potential biomarker for liver fibrosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	11/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $425,000 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	15	5/30/2023	NON-COMPETING CONTINUATION	$425,000
2023	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	10/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $425,000

Issue Date FY: 2022 ( Subtotal = $424,944 )
2022	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	7/21/2022	NON-COMPETING CONTINUATION	$424,944
														Subtotal = $424,944

Issue Date FY: 2021 ( Subtotal = $287,292 )
2021	2021	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	6/15/2021	NON-COMPETING CONTINUATION	$287,292
														Subtotal = $287,292

Issue Date FY: 2020 ( Subtotal = $423,354 )
2020	2020	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	6/24/2020	NON-COMPETING CONTINUATION	$423,354
														Subtotal = $423,354

Issue Date FY: 2019 ( Subtotal = $200,350 )
2019	2019	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	9/17/2019	COMPETING CONTINUATION	$200,350
2019	2018	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $200,350

Issue Date FY: 2018 ( Subtotal = $278,823 )
2018	2018	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	7/12/2018	NON-COMPETING CONTINUATION	$278,823
														Subtotal = $278,823

Issue Date FY: 2017 ( Subtotal = $357,911 )
2017	2017	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	7/11/2017	NON-COMPETING CONTINUATION	$357,911
														Subtotal = $357,911

Issue Date FY: 2016 ( Subtotal = $367,315 )
2016	2016	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	7/29/2016	NON-COMPETING CONTINUATION	$367,315
														Subtotal = $367,315

Issue Date FY: 2015 ( Subtotal = $285,360 )
2015	2015	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/20/2015	NON-COMPETING CONTINUATION	$310,418
2015	2015	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	8/27/2015	NON-COMPETING CONTINUATION	-$25,058
														Subtotal = $285,360

Issue Date FY: 2014 ( Subtotal = $348,825 )
2014	2014	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	8/11/2014	COMPETING CONTINUATION	$348,825
2014	2013	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/6/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $348,825

Issue Date FY: 2013 ( Subtotal = $338,969 )
2013	2013	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/1/2013	NON-COMPETING CONTINUATION	$338,969
														Subtotal = $338,969

Issue Date FY: 2012 ( Subtotal = $247,537 )
2012	2012	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	9/14/2012	NON-COMPETING CONTINUATION	$247,537
														Subtotal = $247,537

Issue Date FY: 2011 ( Subtotal = $306,771 )
2011	2011	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/2/2011	NON-COMPETING CONTINUATION	$306,771
														Subtotal = $306,771

Issue Date FY: 2010 ( Subtotal = $283,003 )
2010	2010	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	8/11/2010	NON-COMPETING CONTINUATION	$283,003
2010	2009	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	1/6/2010	NEW	$0
														Subtotal = $283,003

Issue Date FY: 2009 ( Subtotal = $213,458 )
2009	2009	CHILDRENS HOSPITAL OF LOS ANGELES-SCH OF PHYSICAL THER	4650 SUNSET BOULEVARD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/4/2009	NEW	$213,458
														Subtotal = $213,458

Grand Total All Awards = $4,788,912

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Limited Competition for the Continuation of the Childhood Liver Disease Research Network (ChilLDRen) Clinical Centers.

Award Number: U01DK084538

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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