Saturday, April 20, 2024 4/20/2024

USC-UCLA Drug-Induced Liver Injury (DILI) Clinical Center.

Award Number: U01DK083020
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Project Summary/Abstract The USC-UCLA Drug-Induced Liver Injury Clinical Center (CC) proposal in response to RFA-DK-17-509 “Limited Competition for the Continuation of the Drug Induced Liver Injury Network (DILIN) Clinical Centers” hopes to continue to participate with the other CCs to advance the scientific knowledge and clinical evaluation of DILI. Our proposal will continue to combine the only two medical schools in Los Angeles County allowing us to be able to uniquely capture and enroll DILI cases into the Networks database supervised by the Data Coordinating Center (DCC). The 10.1 M residents of Los Angeles County (2016) are an unmatched resource composed of the most ethnically diverse population in the United States. Our proposal continues to utilize the expertise and talents from Keck School of Medicine of USC and David Geffen School of Medicine at UCLA. The enrollment of a large number of bona fide and ill patients with close follow up has demonstrated our CC’s ability to capture DILIN cases in this diverse populations with little overlap in etiology for DILI other than for HDS in our respective patient populations. The Specific Aims for the continuation of the USC-UCLA DILI CC are to: 1) Continued enrollment of high quality bona fide DILIN case from under represented and Pediatric populations with emphasis on increasing enrollment of acute cases; 2) Development of a treatment trial for cholestatic liver injury; 3) Development of a treatment trial for acute hepatocellular Injury; and 4) Continued support of the DILIN’s effort to develop causality assessment instruments and development of a pilot project for a pharmacovigilance protocol for adverse liver injury due to medication or HDS.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	16	1/12/2024	COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	11/14/2023	COMPETING CONTINUATION	$141,007
2024	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	11/14/2023	NON-COMPETING CONTINUATION	-$141,007
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $362,836 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	9/1/2023	COMPETING CONTINUATION	$362,836
2023	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	2/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $362,836

Issue Date FY: 2022 ( Subtotal = $280,240 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	8/9/2022	NON-COMPETING CONTINUATION	$280,240
														Subtotal = $280,240

Issue Date FY: 2021 ( Subtotal = $288,032 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	8/17/2021	NON-COMPETING CONTINUATION	$288,032
														Subtotal = $288,032

Issue Date FY: 2020 ( Subtotal = $351,888 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	8/10/2020	NON-COMPETING CONTINUATION	$351,888
														Subtotal = $351,888

Issue Date FY: 2019 ( Subtotal = $353,032 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	8/14/2019	NON-COMPETING CONTINUATION	$353,032
2019	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	11/9/2018	COMPETING CONTINUATION	$57,539
2019	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	11/9/2018	NON-COMPETING CONTINUATION	-$57,539
														Subtotal = $353,032

Issue Date FY: 2018 ( Subtotal = $398,489 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	8/24/2018	COMPETING CONTINUATION	$398,489
														Subtotal = $398,489

Issue Date FY: 2017 ( Subtotal = $312,550 )
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	10	9/1/2017	NON-COMPETING CONTINUATION	$312,550
2017	2016	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	11/18/2016	EXTENSION WITH OR WITHOUT FUNDS	$97,009
2017	2015	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	11/18/2016	NON-COMPETING CONTINUATION	-$97,009
														Subtotal = $312,550

Issue Date FY: 2016 ( Subtotal = $289,155 )
2016	2016	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	8/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$289,155
														Subtotal = $289,155

Issue Date FY: 2015 ( Subtotal = $330,732 )
2015	2015	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	8/25/2015	NON-COMPETING CONTINUATION	$330,732
														Subtotal = $330,732

Issue Date FY: 2014 ( Subtotal = $334,892 )
2014	2014	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	9/3/2014	NON-COMPETING CONTINUATION	$334,892
														Subtotal = $334,892

Issue Date FY: 2013 ( Subtotal = $337,075 )
2013	2013	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	9/2/2013	COMPETING CONTINUATION	$337,075
														Subtotal = $337,075

Issue Date FY: 2012 ( Subtotal = $258,628 )
2012	2012	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/23/2012	NON-COMPETING CONTINUATION	$258,628
														Subtotal = $258,628

Issue Date FY: 2011 ( Subtotal = $264,806 )
2011	2011	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	9/9/2011	NON-COMPETING CONTINUATION	$264,806
														Subtotal = $264,806

Issue Date FY: 2010 ( Subtotal = $132,140 )
2010	2010	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/19/2010	NON-COMPETING CONTINUATION	$132,140
														Subtotal = $132,140

Issue Date FY: 2009 ( Subtotal = $247,311 )
2009	2009	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	2	9/4/2009	NON-COMPETING CONTINUATION	$247,311
2009	2008	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Digestive Diseases and Nutrition Research	000	1	2/13/2009	NEW	$0
2009	2008	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Digestive Diseases and Nutrition Research	001	1	3/9/2009	NEW	$0
														Subtotal = $247,311

Issue Date FY: 2008 ( Subtotal = $263,547 )
2008	2008	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Digestive Diseases and Nutrition Research	000	1	9/29/2008	NEW	$263,547
														Subtotal = $263,547

Grand Total All Awards = $4,805,353

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USC-UCLA Drug-Induced Liver Injury (DILI) Clinical Center.

Award Number: U01DK083020

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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