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Midwest Hepatitis B Consortium

Award Number: U01DK082871
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2008
PERIOD OF PERFORMANCE END DATE: 05/31/2022

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Midwest Hepatitis B Consortium - DESCRIPTION (provided by applicant): We propose to renew the participation of the Midwest Hepatitis B Consortium as a member of the Hepatitis B Research Network (HBRN). The Midwest Consortium consists of three sites: Saint Louis University adult, Saint Louis University pediatric and Washington University adult. The consortium has functioned well and collaboratively in recruiting and enrolling patients in the HBRN studies and its performance compares favorably to that of other network sites, including some of those in much larger cities with many more individuals at-risk for hepatitis B. In addition to their successes in recruiting an enrolling, investigators at each site within the Midwest Consortium brings a special strength to the Network: Thus, Dr. Di Bisceglie (SLU adult) provides experience and leadership, including his role as co-chair of the Ancillary Studies Committee. Dr Teckman (SLU pediatric) is PI of one of only 7 pediatric sites within the network, and Dr Lisker-Melman (Wash. U adult) is positioned to be a major contributor to the separately- funded ancillary study on HIV-HBV co-infection that is being conducted by the Network. The Midwest Consortium is therefore well positioned to continue enrolling patients in the existing studies and also to contribute to the development of new therapeutic studies for the network. Finally, Dr. Di Bisceglie has been very successful is establishing basic research collaborations to enhance the productivity of the Network. Thus, his long-time collaborator, Dr John Tavis is a recipient of a grant supplement to conduct an approved Virology ancillary study aimed at developing RNaseH inhibitors as a novel method of treatment for hepatitis B. This application also includes a proposal from Dr Adam Gehring, an experienced HBV immunologist at SLU which will make use of biorepository specimens to study antiviral effects of various immunomodulators, including GM-CSF. If these studies confirm preliminary observations, they would form the basis for a novel therapeutic approach to be adopted in the next phase of the HBRN in which patients already on long-term antiviral therapy with complete suppression of HBV could receive immunomodulators in an attempt to enhance the rate of HBsAg clearance and to allow patients to stop their antiviral therapy


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$135,969 )
2023	2019	SAINT LOUIS UNIVERSITY	221 N GRAND BLVD	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	11/2/2022	NON-COMPETING CONTINUATION	-$135,969
														Subtotal = -$135,969

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	SAINT LOUIS UNIVERSITY	ONE NORTH GRAND	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	6/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	SAINT LOUIS UNIVERSITY	ONE NORTH GRAND	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	5/14/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $263,769 )
2019	2019	SAINT LOUIS UNIVERSITY	ONE NORTH GRAND	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	6/6/2019	NON-COMPETING CONTINUATION	$263,769
														Subtotal = $263,769

Issue Date FY: 2018 ( Subtotal = $357,547 )
2018	2018	SAINT LOUIS UNIVERSITY	ONE NORTH GRAND	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	7/12/2018	NON-COMPETING CONTINUATION	$357,547
														Subtotal = $357,547

Issue Date FY: 2017 ( Subtotal = $265,560 )
2017	2017	SAINT LOUIS UNIVERSITY	ONE NORTH GRAND	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	6/28/2017	NON-COMPETING CONTINUATION	$265,560
														Subtotal = $265,560

Issue Date FY: 2016 ( Subtotal = $306,114 )
2016	2016	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	7/29/2016	NON-COMPETING CONTINUATION	$306,114
														Subtotal = $306,114

Issue Date FY: 2015 ( Subtotal = $726,613 )
2015	2015	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	8	8/27/2015	COMPETING CONTINUATION	$511,412
2015	2015	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	11/6/2014	SUPPLEMENT FOR EXPANSION	$215,201
2015	2014	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	8/24/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $726,613

Issue Date FY: 2014 ( Subtotal = $536,665 )
2014	2014	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/28/2014	NON-COMPETING CONTINUATION	$536,665
														Subtotal = $536,665

Issue Date FY: 2013 ( Subtotal = $576,314 )
2013	2013	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	8/20/2013	NON-COMPETING CONTINUATION	$576,314
														Subtotal = $576,314

Issue Date FY: 2012 ( Subtotal = $360,237 )
2012	2012	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	9/14/2012	NON-COMPETING CONTINUATION	$360,237
														Subtotal = $360,237

Issue Date FY: 2011 ( Subtotal = $442,611 )
2011	2011	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	9/8/2011	NON-COMPETING CONTINUATION	$442,611
														Subtotal = $442,611

Issue Date FY: 2010 ( Subtotal = $349,900 )
2010	2010	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/7/2010	NON-COMPETING CONTINUATION	$349,900
														Subtotal = $349,900

Issue Date FY: 2009 ( Subtotal = $336,592 )
2009	2009	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/11/2009	NON-COMPETING CONTINUATION	$336,592
														Subtotal = $336,592

Issue Date FY: 2008 ( Subtotal = $137,744 )
2008	2008	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Digestive Diseases and Nutrition Research	000	1	9/30/2008	NEW	$137,744
														Subtotal = $137,744

Grand Total All Awards = $4,523,697

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Midwest Hepatitis B Consortium

Award Number: U01DK082871

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2008

PERIOD OF PERFORMANCE END DATE: 05/31/2022

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