Thursday, November 21, 2024 11/21/2024

Chronic Kidney Disease in Children (CKiD V)

Award Number: U01DK066143
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT For the Chronic Kidney Disease in Children (CKiD) Study renewal, we will continue to follow our existing cohort, and will recruit children between 14 and 17 years of age to enhance the power of the study to characterize the decline of kidney function and the development of cardiovascular disease as they transition to young adulthood. Remote data collection will be coordinated and conducted through national laboratory contractors who can assess vitals and obtain labs in the participant’s home. Data will be obtained between CKiD study visits by conducting data extraction through electronic health records. The Research Electronic Data Capture (REDCap) system will be leveraged to allow automated reporting for coordination and clinical activities and improve options for harmonization with external cohorts including CureGN and NEPTUNE. Most importantly, it will enable the study to collect data through web-based entry by computer or mobile phone directly by participants. Important research questions will include (a) methods to identify risk factors for decline in kidney function during childhood through young adulthood including acceleration of glomerular filtration rate (GFR) decline during puberty and the effect of acute kidney injury (AKI) on chronic kidney disease (CKD); (b) statistical-based machine learning prediction methodology to characterize the joint predictive value of clinical markers and social determinants of disease progression for individualized inference; (c) analytic strategies to describe risk factors for cardiovascular changes and outcomes via home blood pressure monitoring and assessing cardiac and vascular target organ damage, including characterizing changes in biomarkers like trajectories of indicators of metabolic bone health; (d) statistical methods to validate and refine GFR equations in young adulthood for consistent estimates during the transition from pediatric to adult care; and (e) methods to assess effects of therapies and exposures on outcomes including constructs of social function and emotional well-being.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,124,419 )
2024	2024	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	7/9/2024	NON-COMPETING CONTINUATION	$1,124,419
														Subtotal = $1,124,419

Issue Date FY: 2023 ( Subtotal = $1,166,170 )
2023	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	21	9/12/2023	COMPETING CONTINUATION	$1,166,170
2023	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	21	9/13/2023	COMPETING CONTINUATION	$0
2023	2022	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	20	6/15/2023	NON-COMPETING CONTINUATION	$0
2023	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	1/31/2023	NON-COMPETING CONTINUATION	$0
2023	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	12/7/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,166,170

Issue Date FY: 2022 ( Subtotal = $926,300 )
2022	2022	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	20	8/1/2022	NON-COMPETING CONTINUATION	$926,300
2022	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	1/27/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	3/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $926,300

Issue Date FY: 2021 ( Subtotal = $1,090,645 )
2021	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	19	9/17/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	19	7/19/2021	NON-COMPETING CONTINUATION	$935,407
2021	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	19	8/12/2021	SUPPLEMENT FOR EXPANSION	$155,238
2021	2020	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	11/17/2020	NON-COMPETING CONTINUATION	$0
2021	2019	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	4/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,090,645

Issue Date FY: 2020 ( Subtotal = $945,083 )
2020	2020	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	7/13/2020	NON-COMPETING CONTINUATION	$945,083
2020	2019	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	3/23/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $945,083

Issue Date FY: 2019 ( Subtotal = $961,522 )
2019	2019	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	17	7/31/2019	NON-COMPETING CONTINUATION	$961,522
2019	2019	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	006	17	8/15/2019	NON-COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	16	3/25/2019	COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	16	2/27/2019	COMPETING CONTINUATION	-$249,411
2019	2018	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	12/28/2018	COMPETING CONTINUATION	$836,052
2019	2017	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	15	2/27/2019	NON-COMPETING CONTINUATION	$249,411
2019	2017	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	12/28/2018	NON-COMPETING CONTINUATION	-$836,052
														Subtotal = $961,522

Issue Date FY: 2018 ( Subtotal = $1,004,499 )
2018	2018	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	8/24/2018	COMPETING CONTINUATION	$1,004,499
														Subtotal = $1,004,499

Issue Date FY: 2017 ( Subtotal = $989,810 )
2017	2017	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	15	8/23/2017	NON-COMPETING CONTINUATION	$989,810
2017	2016	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	14	2/27/2017	EXTENSION WITH OR WITHOUT FUNDS	$508,625
2017	2015	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	2/27/2017	NON-COMPETING CONTINUATION	-$508,625
														Subtotal = $989,810

Issue Date FY: 2016 ( Subtotal = $1,313,262 )
2016	2016	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	14	8/4/2016	SUPPLEMENT FOR EXPANSION	$315,000
2016	2016	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	7/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$998,262
														Subtotal = $1,313,262

Issue Date FY: 2015 ( Subtotal = $1,007,756 )
2015	2015	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	8/18/2015	NON-COMPETING CONTINUATION	$1,007,756
														Subtotal = $1,007,756

Issue Date FY: 2014 ( Subtotal = $1,148,466 )
2014	2014	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/9/2014	NON-COMPETING CONTINUATION	$1,016,466
2014	2014	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	9/10/2014	SUPPLEMENT FOR EXPANSION	$132,000
														Subtotal = $1,148,466

Issue Date FY: 2013 ( Subtotal = $955,945 )
2013	2013	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	8/29/2013	COMPETING CONTINUATION	$955,945
														Subtotal = $955,945

Issue Date FY: 2012 ( Subtotal = $1,067,525 )
2012	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	9/5/2012	SUPPLEMENT FOR EXPANSION	$75,000
2012	2012	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/5/2012	NON-COMPETING CONTINUATION	$992,525
														Subtotal = $1,067,525

Issue Date FY: 2011 ( Subtotal = $992,223 )
2011	2011	CHILDREN'S MERCY HOSPITAL	2401 GILLHAM ROAD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	9/12/2011	NON-COMPETING CONTINUATION	$992,223
														Subtotal = $992,223

Grand Total All Awards = $20,864,843

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Chronic Kidney Disease in Children (CKiD V)

Award Number: U01DK066143

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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