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The Environmental Determinants of Diabetes in the Young (TEDDY) Study, Washington Clinical Center

Award Number: U01DK063829
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT The Environmental Determinants of Diabetes in the Young (TEDDY) study was initiated in 2003 by six clinical centers in the United States and Europe, including ours, to identify infectious agents, dietary factors, or other environmental exposures that may trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). Additional long-term scientific goals include assessment of potential gene-environment interactions affecting development of islet autoimmunity or T1D, gaining insight on triggering mechanisms through detailed multi-omics analyses, and sharing collected specimens with broader scientific community for studies of T1D pathogenesis and prevention. A total of 424,788 newborns were screened by HLA-DR,DQ genotyping to identify children at increased risk for T1D and 8,676 enrolled for quarterly follow-up until age 4 and semi-annually thereafter until age 15. Now, 13 years after enrollment began, 5731 (66%) remain actively engaged in the protocol. Our Washington State Clinical Center enrolled 1,376 TEDDY participants. As of 2/28/18, 83 of those have developed persistent confirmed islet autoantibodies and 29 have been diagnosed with T1D. Detailed analyses of biological samples from the entire cohort, along with even more comprehensive multi- omics analyses in selected individuals, will provide a rich dataset to complement the intensive collection of exposure data and highly efficient ascertainment of islet autoimmunity and T1D endpoints in the entire cohort. Specific aims of this renewal application for this multi-center, prospective cohort study for the next 5 years are: 1. Follow the TEDDY cohort of high-risk children for development of islet autoimmunity, diabetes, celiac disease and autoimmune thyroid disease until 15 years of age; collect biological specimens and epidemiological data according to the study protocol. 2. Characterize genetic, epigenetic, transcriptomic, proteomic and metabolomic determinants of islet autoimmunity and T1D in the study participants. 3. Prospectively assess infectious, dietary and other environmental exposures of study participants, as triggers of islet autoimmunity and/or promotors of progression to T1D. A successful study outcome will provide a dataset unprecedented in depth and breadth, to help elucidate specific exposures and mechanisms serving in the etiology and pathogenesis of islet autoimmunity, T1D, and closely related autoimmune diseases. The results will support the development of new strategies to prevent, delay, or reverse the disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	PACIFIC NW RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	3/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $508,256 )
2022	2022	PACIFIC NW RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	8/23/2022	NON-COMPETING CONTINUATION	$508,256
2022	2021	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	2/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $508,256

Issue Date FY: 2021 ( Subtotal = $662,547 )
2021	2021	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	8/5/2021	NON-COMPETING CONTINUATION	$662,547
														Subtotal = $662,547

Issue Date FY: 2020 ( Subtotal = $756,769 )
2020	2020	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	14	7/29/2020	NON-COMPETING CONTINUATION	$756,769
2020	2019	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	2/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $756,769

Issue Date FY: 2019 ( Subtotal = $798,687 )
2019	2019	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	8/8/2019	NON-COMPETING CONTINUATION	$798,687
														Subtotal = $798,687

Issue Date FY: 2018 ( Subtotal = $801,815 )
2018	2018	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/18/2018	COMPETING CONTINUATION	$801,815
2018	2018	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	9/21/2018	COMPETING CONTINUATION	$0
2018	2018	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	9/19/2018	COMPETING CONTINUATION	$0
														Subtotal = $801,815

Issue Date FY: 2017 ( Subtotal = -$537,248 )
2017	2012	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	3/1/2017	NON-COMPETING CONTINUATION	-$537,248
														Subtotal = -$537,248

Issue Date FY: 2012 ( Subtotal = $863,379 )
2012	2012	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	5/31/2012	NON-COMPETING CONTINUATION	$863,379
														Subtotal = $863,379

Issue Date FY: 2011 ( Subtotal = $586,783 )
2011	2011	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	7/1/2011	NON-COMPETING CONTINUATION	$586,783
														Subtotal = $586,783

Issue Date FY: 2010 ( Subtotal = $982,458 )
2010	2010	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	8	7/28/2010	NON-COMPETING CONTINUATION	$836,415
2010	2010	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Trans-NIH Recovery Act Research Support	000	7	12/4/2009	SUPPLEMENT FOR EXPANSION	$12,000
2010	2010	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Trans-NIH Recovery Act Research Support	005	8	8/9/2010	SUPPLEMENT FOR EXPANSION	$134,043
2010	2009	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	12/15/2009	NON-COMPETING CONTINUATION	$0
2010	2009	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	12/15/2009	NON-COMPETING CONTINUATION	$0
2010	2007	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	5	12/23/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $982,458

Issue Date FY: 2009 ( Subtotal = $659,983 )
2009	2009	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	9/30/2009	NON-COMPETING CONTINUATION	$0
2009	2009	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	7/1/2009	NON-COMPETING CONTINUATION	$558,546
2009	2007	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/19/2009	NON-COMPETING CONTINUATION	$101,437
														Subtotal = $659,983

Issue Date FY: 2008 ( Subtotal = $788,400 )
2008	2008	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	8/29/2008	COMPETING CONTINUATION	$788,400
														Subtotal = $788,400

Issue Date FY: 2007 ( Subtotal = $745,063 )
2007	2007	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	3/2/2007	NON-COMPETING CONTINUATION	$745,063
														Subtotal = $745,063

Issue Date FY: 2006 ( Subtotal = $929,041 )
2006	2006	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/27/2006	NON-COMPETING CONTINUATION	$929,041
														Subtotal = $929,041

Issue Date FY: 2004 ( Subtotal = $1,000,000 )
2004	2004	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/8/2004	NON-COMPETING CONTINUATION	$1,000,000
														Subtotal = $1,000,000

Issue Date FY: 2003 ( Subtotal = $1,000,000 )
2003	2003	PACIFIC NORTHWEST RESEARCH INSTITUTE	720 BROADWAY	SEATTLE	WA	98122	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1		NEW	$1,000,000
														Subtotal = $1,000,000

Grand Total All Awards = $10,545,933

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The Environmental Determinants of Diabetes in the Young (TEDDY) Study, Washington Clinical Center

Award Number: U01DK063829

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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