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IBD Gene Mapping by Clinical and Population Subset

Award Number: U01DK062431
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are complex genetic disorders of the gastrointestinal tract, and a major health burden to patients and society. Tremendous progress has been made in dissecting IBD genetic etiology with identification of over 200 IBD loci by genome wide association studies (GWAS) but mainly limited to persons of European ancestry. The IBD Genetics Consortium (IBDGC) was established to facilitate multicenter collaborative studies of 6 Genetics Research Centers (GRCs) organized with a Data Coordinating Center (DCC). Our GRC at Johns Hopkins (JHGRC) has contributed to all IBDGC studies, meeting recruitment objectives and taking roles in IBDGC leadership positions. Our particular focus is on African American (AA) IBD genetics. We performed the first large-scale evaluation of European loci in the AA population, replicating several genes, but also finding unique African-ancestral variants within these loci, as well as identified multiple admixture significant loci. We also published the first AA IBD genome-wide association study (GWAS), a collaborative effort that identified two African-specific gene loci, and replicated multiple additional European loci. We have also explored why some loci with proven risk variants in Europeans and other populations only cause disease in one ancestral population but not others. More research in AA IBD is needed to understand the etiology of IBD in this ancestrally distinct, major American population. In this application we will re-evaluate the AA GWAS by better imputation, evaluate whole genome sequencing data to test low frequency and rare variants, and perform an evaluation for chromosome X variants. We will recruit a large number of AA IBD patients through our own and multiple Satellite Recruitment Centers to power a second AA IBD GWAS, both UC and CD, and meta-analyze with the first to identify more novel loci, identify more African specific risk variants, and replicate known loci for this population and replicate our admixture loci. We will also incorporate diverse data sources to incorporate into our GWAS analyses including RNA-Seq currently being generated on lymophoblastoid cell lines from AA CD cases and controls, and RNA-Seq that we will generate in colonic biopsies from UC cases and controls. We will evaluate chromatin differences and expression of genes in cell types relevant to IBD from European, AA and East Asian ancestries in an effort to better understand locus heterogeneity by ancestry. We will continue to participate in all IBDGC activities to maximize the Impact of IBD genetics research by this cooperative funding mechanism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $498,261 )
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	22	7/14/2023	NON-COMPETING CONTINUATION	$498,261
2023	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	4/19/2023	COMPETING CONTINUATION	$12,224
2023	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	4/19/2023	NON-COMPETING CONTINUATION	-$12,224
														Subtotal = $498,261

Issue Date FY: 2022 ( Subtotal = $529,546 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	21	9/20/2022	COMPETING CONTINUATION	$529,546
2022	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	10/14/2021	NON-COMPETING CONTINUATION	$0
2022	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	7/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $529,546

Issue Date FY: 2021 ( Subtotal = $451,377 )
2021	2021	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	8/31/2021	NON-COMPETING CONTINUATION	$451,377
2021	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	8/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $451,377

Issue Date FY: 2020 ( Subtotal = $451,377 )
2020	2020	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	8/13/2020	NON-COMPETING CONTINUATION	$451,377
														Subtotal = $451,377

Issue Date FY: 2019 ( Subtotal = $467,173 )
2019	2019	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	8/23/2019	NON-COMPETING CONTINUATION	$467,173
														Subtotal = $467,173

Issue Date FY: 2018 ( Subtotal = $636,641 )
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	9/14/2018	SUPPLEMENT FOR EXPANSION	$159,303
2018	2018	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	9/7/2018	NON-COMPETING CONTINUATION	$477,338
2018	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	3/26/2018	COMPETING CONTINUATION	$85,689
2018	2016	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	3/26/2018	EXTENSION WITH OR WITHOUT FUNDS	-$85,689
														Subtotal = $636,641

Issue Date FY: 2017 ( Subtotal = $505,613 )
2017	2017	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	675 HOES LN	PISCATAWAY	NJ	08854	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	16	9/19/2017	COMPETING CONTINUATION	$505,613
2017	2016	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	15	4/7/2017	EXTENSION WITH OR WITHOUT FUNDS	$114,798
2017	2015	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	4/7/2017	NON-COMPETING CONTINUATION	-$114,798
														Subtotal = $505,613

Issue Date FY: 2016 ( Subtotal = $416,284 )
2016	2016	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	9/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$416,284
														Subtotal = $416,284

Issue Date FY: 2015 ( Subtotal = $424,697 )
2015	2015	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	9/18/2015	NON-COMPETING CONTINUATION	$424,697
														Subtotal = $424,697

Issue Date FY: 2014 ( Subtotal = $424,698 )
2014	2014	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	9/12/2014	NON-COMPETING CONTINUATION	$424,698
														Subtotal = $424,698

Issue Date FY: 2013 ( Subtotal = $409,831 )
2013	2013	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/13/2013	NON-COMPETING CONTINUATION	$409,831
														Subtotal = $409,831

Issue Date FY: 2012 ( Subtotal = $522,613 )
2012	2012	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	9/24/2012	SUPPLEMENT FOR EXPANSION	$97,916
2012	2012	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	9/21/2012	COMPETING CONTINUATION	$424,697
2012	2011	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/21/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $522,613

Issue Date FY: 2011 ( Subtotal = $414,869 )
2011	2011	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/13/2011	NON-COMPETING CONTINUATION	$414,869
														Subtotal = $414,869

Issue Date FY: 2010 ( Subtotal = $369,812 )
2010	2010	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Digestive Diseases and Nutrition Research	000	9	9/20/2010	NON-COMPETING CONTINUATION	$369,812
														Subtotal = $369,812

Issue Date FY: 2009 ( Subtotal = $533,265 )
2009	2009	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Digestive Diseases and Nutrition Research	000	8	9/11/2009	NON-COMPETING CONTINUATION	$369,267
2009	2009	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Trans-NIH Recovery Act Research Support	001	8	9/29/2009	SUPPLEMENT FOR EXPANSION	$163,998
														Subtotal = $533,265

Issue Date FY: 2008 ( Subtotal = $369,141 )
2008	2008	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Digestive Diseases and Nutrition Research	000	7	9/17/2008	NON-COMPETING CONTINUATION	$369,141
														Subtotal = $369,141

Issue Date FY: 2007 ( Subtotal = $364,080 )
2007	2007	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Digestive Diseases and Nutrition Research	000	6	9/21/2007	COMPETING CONTINUATION	$364,080
														Subtotal = $364,080

Issue Date FY: 2006 ( Subtotal = $338,125 )
2006	2006	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Digestive Diseases and Nutrition Research	000	5	9/18/2006	NON-COMPETING CONTINUATION	$338,125
														Subtotal = $338,125

Issue Date FY: 2004 ( Subtotal = $575,000 ) (Continued on the next page)
Grand Total All Awards = $9,302,403

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IBD Gene Mapping by Clinical and Population Subset

Award Number: U01DK062431

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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