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Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes

Award Number: U01DK062423
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract To date more than 200 genetic variants are known to be associated with inflammatory bowel disease (IBD). The majority of these have been identified by genome-wide association studies (GWAS). The individual Genetic Research Centers (GRCs) and the collective NIDDK IBD Genetics Consortium have successfully interacted for the last fifteen years to lead many of these discoveries. However, despite significant progress it is still unknown how the majority of these variants or other risk factors lead to development of IBD and its two major subtypes - Crohn’s disease (CD) and ulcerative colitis (UC). Answering these questions is critical to advancing our knowledge of IBD pathophysiology. Since 2002, Dr. Silverberg has established a very large, comprehensive registry of well characterized, longitudinally followed IBD patients at Mount Sinai Hospital in addition to accompanying biospecimens stored at his laboratory at the Lunenfeld-Tanenbaum Research Institute to facilitate research in IBD. Utilizing these resources and applying new expertise in cellular, genomic and immune profiling, it is anticipated that the proposed studies will help to make significant progress in the unmet needs described above. The IBDGC working together with the UTGRC will study comprehensively the genetic architecture of non-European ancestry IBD populations and utilize the power of its infrastructure to better elucidate the pathophysiology of acute severe ulcerative colitis and perianal Crohn’s disease. The UTGRC, specifically, will advance the understanding of UC pathophysiology by integrating imaging mass cytometry, spatial transcriptomics and scRNA-seq, in conjunction with tissue-associated microbiome analysis, to develop a comprehensive understanding of the immune, genomic, cellular and microbial factors that contribute to persistent histologic inflammation and mechanisms of clinical relapse in UC. Utilizing the power of these technologies, also provides a unique opportunity to go “back in time” to study critical events that lead to the development of colorectal cancer in UC – a poorly understood complication with significant mortality. By applying similar techniques in a retrospective cohort, the cellular and immune factors that lead to treatment refractory CD. Despite the progress in advanced biologic therapy, there are still a significant portion of patients who fail multiple therapies and have persistent inflammation. Taken together, through the studies proposed, it is anticipated that significant advances will be made toward better understanding the functional biology of IBD genetic variation and to enable the translation of these data to clinically meaningful tools that will lead improved outcomes for individuals affected by IBD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $377,127 )
2024	2024	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	7/17/2024	NON-COMPETING CONTINUATION	$377,127
2024	2023	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	12/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $377,127

Issue Date FY: 2023 ( Subtotal = $392,727 )
2023	2023	REDACTED DUE TO PII		TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	22	7/13/2023	NON-COMPETING CONTINUATION	$392,727
2023	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	21	5/4/2023	COMPETING CONTINUATION	$0
2023	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	21	2/23/2023	COMPETING CONTINUATION	$404,685
2023	2021	REDACTED DUE TO PII		TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	12/14/2022	NON-COMPETING CONTINUATION	$0
2023	2021	REDACTED DUE TO PII		TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	20	2/23/2023	NON-COMPETING CONTINUATION	-$307,844
2023	2020	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	2/23/2023	NON-COMPETING CONTINUATION	-$96,841
														Subtotal = $392,727

Issue Date FY: 2022 ( Subtotal = $1 )
2022	2022	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	9/20/2022	COMPETING CONTINUATION	$1
2022	2016	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	10/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2021 ( Subtotal = $307,844 )
2021	2021	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	8/31/2021	NON-COMPETING CONTINUATION	$307,844
														Subtotal = $307,844

Issue Date FY: 2020 ( Subtotal = $313,995 )
2020	2020	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	8/18/2020	NON-COMPETING CONTINUATION	$313,995
2020	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	11/27/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $313,995

Issue Date FY: 2019 ( Subtotal = $437,887 )
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	8/23/2019	NON-COMPETING CONTINUATION	$329,910
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	18	9/13/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	9/12/2019	SUPPLEMENT FOR EXPANSION	$107,977
														Subtotal = $437,887

Issue Date FY: 2018 ( Subtotal = $423,939 )
2018	2018	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	9/18/2018	SUPPLEMENT FOR EXPANSION	$107,825
2018	2018	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	9/10/2018	NON-COMPETING CONTINUATION	$316,114
2018	2017	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	1/4/2018	COMPETING CONTINUATION	$50,245
2018	2016	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	1/4/2018	NON-COMPETING CONTINUATION	-$50,245
														Subtotal = $423,939

Issue Date FY: 2017 ( Subtotal = $311,979 )
2017	2017	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	9/19/2017	COMPETING CONTINUATION	$311,979
														Subtotal = $311,979

Issue Date FY: 2016 ( Subtotal = $433,633 )
2016	2016	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	9/24/2016	NON-COMPETING CONTINUATION	$433,633
														Subtotal = $433,633

Issue Date FY: 2015 ( Subtotal = $283,976 )
2015	2015	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	9/18/2015	NON-COMPETING CONTINUATION	$283,976
														Subtotal = $283,976

Issue Date FY: 2014 ( Subtotal = $275,938 )
2014	2014	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	13	9/12/2014	NON-COMPETING CONTINUATION	$275,938
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	4/15/2014	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	12/6/2013	EXTENSION WITH OR WITHOUT FUNDS	-$254,642
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	12/11/2013	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	4/11/2014	EXTENSION WITH OR WITHOUT FUNDS	-$254,642
														Subtotal = $275,938

Issue Date FY: 2013 ( Subtotal = $254,642 )
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	12/6/2013	EXTENSION WITH OR WITHOUT FUNDS	-$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	12	4/15/2014	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/12/2013	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	12/11/2013	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	4/11/2014	EXTENSION WITH OR WITHOUT FUNDS	-$254,642
														Subtotal = $254,642

Issue Date FY: 2012 ( Subtotal = $263,878 )
2012	2012	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	Tornto				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	9/21/2012	COMPETING CONTINUATION	$263,878
2012	2011	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	TORNTO		0		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/21/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $263,878

Issue Date FY: 2011 ( Subtotal = $244,036 )
2011	2011	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	Tornto				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/13/2011	NON-COMPETING CONTINUATION	$244,036
														Subtotal = $244,036

Grand Total All Awards = $6,468,837

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Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes

Award Number: U01DK062423

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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