Tuesday, August 9, 2022 8/9/2022

Impact of Genetic Variability on Cellular Pathways and Host-Microbiome Interactio

Award Number: U01DK062423
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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DESCRIPTION (provided by applicant): To date more than 100 genetic variants are known to be associated with inflammatory bowel disease (IBD). The majority of these have been identified by genome-wide association studies (GWAS). The individual Genetic Research Centers (GRCs) and the collective NIDDK IBD Genetics Consortium have successfully interacted for the last ten years to lead many of these discoveries. However, despite significant progress it is still unknown how the vast majority of these variants lead to IBD. Answering these questions is critical to advancing our knowledge of IBD pathophysiology. The University of Toronto GRC, led by Dr. Mark Silverberg, has made unique and substantial contributions in this field by virtue of its longstanding clinical and genetics expertise in IBD. Since 2002, Dr. Silverberg has established a very large, comprehensive registry of well characterized, longitudinally followed IBD patients at Mount Sinai Hospital in addition to accompanying biospecimens stored at his laboratory at the Samuel Lunenfeld Research Institute in order to facilitate research in IBD. Utilizing these resources, the UTGRC will advance the understanding of IBD pathophysiology in the following ways: (1) To identify gene expression profiles and pathways that will aid in classifying IBD and in revealing those that are mechanistically important in IBD pathophysiology. This will be accomplished by measuring gene expression profiles in the intestinal tissue of those affected and of healthy controls. (2) To evaluate the interaction between host genetic variation and the intestinal microbiome and determine how these changes affect the phenotypic expression of IBD. This will be accomplished by determining the composition of the microbial flora adherent to the intestinal tissue of those affected and of healthy controls. (3) To continue to work in an interactive fashion with the members of the Consortium to complete the discovery of all genetic variation associated with IBD and to advance our knowledge of the functional biology of such genetic variation such that we will effect change in the outcomes of individuals affected by IBD. This will be accomplished by ongoing clinical patient and biospecimen recruitment and by bringing significant clinical and scientific expertise to the Consortium team.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2016	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	10/1/2021	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2021 ( Subtotal = $307,844 )
2021	2021	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	8/31/2021	NON-COMPETING CONTINUATION	$307,844


Issue Date FY: 2020 ( Subtotal = $313,995 )
2020	2020	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	8/18/2020	NON-COMPETING CONTINUATION	$313,995
2020	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	11/27/2019	SUPPLEMENT FOR EXPANSION	$0


Issue Date FY: 2019 ( Subtotal = $437,887 )
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	8/23/2019	NON-COMPETING CONTINUATION	$329,910
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	9/12/2019	SUPPLEMENT FOR EXPANSION	$107,977
2019	2019	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	18	9/13/2019	SUPPLEMENT FOR EXPANSION	$0


Issue Date FY: 2018 ( Subtotal = $423,939 )
2018	2018	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	9/18/2018	SUPPLEMENT FOR EXPANSION	$107,825
2018	2018	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	9/10/2018	NON-COMPETING CONTINUATION	$316,114
2018	2017	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	1/4/2018	COMPETING CONTINUATION	$50,245
2018	2016	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	1/4/2018	NON-COMPETING CONTINUATION	-$50,245


Issue Date FY: 2017 ( Subtotal = $311,979 )
2017	2017	SINAI HEALTH SYSTEM	600 UNIVERSITY AVE	TORONTO	ON	M5G 1X5		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	9/19/2017	COMPETING CONTINUATION	$311,979


Issue Date FY: 2016 ( Subtotal = $433,633 )
2016	2016	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	9/24/2016	NON-COMPETING CONTINUATION	$433,633


Issue Date FY: 2015 ( Subtotal = $283,976 )
2015	2015	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	9/18/2015	NON-COMPETING CONTINUATION	$283,976


Issue Date FY: 2014 ( Subtotal = $275,938 )
2014	2014	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	13	9/12/2014	NON-COMPETING CONTINUATION	$275,938
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	12/6/2013	EXTENSION WITH OR WITHOUT FUNDS	-$254,642
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	4/15/2014	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	12/11/2013	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2014	2013	MOUNT SINAI HOSPITAL	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	4/11/2014	EXTENSION WITH OR WITHOUT FUNDS	-$254,642


Issue Date FY: 2013 ( Subtotal = $254,642 )
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	12/6/2013	EXTENSION WITH OR WITHOUT FUNDS	-$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	12	4/15/2014	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/12/2013	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	12/11/2013	EXTENSION WITH OR WITHOUT FUNDS	$254,642
2013	2013	MT SINAI HOSP	600 UNIVERSITY AVENUE	TORONTO				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	4/11/2014	EXTENSION WITH OR WITHOUT FUNDS	-$254,642


Issue Date FY: 2012 ( Subtotal = $263,878 )
2012	2012	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	Tornto				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	9/21/2012	COMPETING CONTINUATION	$263,878
2012	2011	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	TORNTO		0		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/21/2012	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2011 ( Subtotal = $244,036 )
2011	2011	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	Tornto				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/13/2011	NON-COMPETING CONTINUATION	$244,036


Issue Date FY: 2010 ( Subtotal = $243,535 )
2010	2010	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	Tornto				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	9	9/20/2010	NON-COMPETING CONTINUATION	$243,535
2010	2008	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	TORNTO		0		CAN	Digestive Diseases and Nutrition Research	001	7	9/14/2010	NON-COMPETING CONTINUATION	$0
2010	2007	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	TORNTO		0		CAN	Digestive Diseases and Nutrition Research	000	6	12/22/2009	COMPETING CONTINUATION	$0


Issue Date FY: 2009 ( Subtotal = $267,201 )
2009	2009	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	Tornto				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	9/14/2009	NON-COMPETING CONTINUATION	$267,201


Issue Date FY: 2008 ( Subtotal = $243,097 )
2008	2008	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	TORNTO		0		CAN	Digestive Diseases and Nutrition Research	000	7	9/15/2008	NON-COMPETING CONTINUATION	$243,097


Issue Date FY: 2007 ( Subtotal = $239,760 )
2007	2007	MOUNT SINAI HOSPITAL/PRINCESS MARGARET	600 UNIVERSITY AVENUE	TORNTO		0		CAN	Digestive Diseases and Nutrition Research	000	6	9/21/2007	COMPETING CONTINUATION	$239,760


Issue Date FY: 2006 ( Subtotal = $305,642 ) (Continued on the next page)
Grand Total All Awards = $5,698,982

Sum of Action Amount is $5,698,982;

Grand Total = $5,698,982

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Impact of Genetic Variability on Cellular Pathways and Host-Microbiome Interactio

Award Number: U01DK062423

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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