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Continuation of the University of Illinois Chicago CRIC Clinical Center

Award Number: U01DK060980
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/28/2001
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Continuation of the University of Illinois Chicago CRIC Clinical Center - PROJECT SUMMARY This application is submitted in response to RFA-DK-22-502, “Limited Competition: Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01)” on behalf of the University of Illinois Chicago (UIC) CRIC Clinical Center. Since its inception in 2001, the CRIC Study has recruited and followed a racially and ethnically diverse cohort of 5,625 participants with reduced kidney function from 13 recruitment sites at seven Clinical Centers across the US. The original aim of CRIC was to establish a clinical research laboratory designed to (a) identify novel predictors of CKD progression, and (b) characterize the manifestations of cardiovascular disease and identify its risk factors among individuals with CKD. As the landmark prospective cohort study of CKD, the CRIC Study has accomplished extensive biological, physiological, and social phenotyping, longitudinal follow- up, and ascertainment of clinical and patient-centered outcomes across multiple domains. Findings from the CRIC Study have defined trajectories of CKD progression, catalogued development and evolution of comorbidities in CKD, and identified a diverse array of factors and pathways that explain the progression and complications of CKD in adults. During the most recent funding cycle (Phase 4: 2018-2023), three innovative sub-protocol studies were implemented to enrich CRIC data with highly granular home-based assessments of kidney function and cardiovascular measures. During the fifth and final phase of the CRIC Study, the major focus will be to (1) ascertain the clinical outcomes for all participants including those enrolled in the Phase 4 sub-protocols, (2) perform analyses linking the sub-protocol measurements to clinical outcomes, (3) integrate data from multiple domains to identify sub-phenotypes underlying the heterogeneity in CKD progression outcomes, (4) conduct final study visits for the full CRIC cohort eligible for Phase 5, (5) create mechanisms for future data collection via linkages with external sources of health data, (6) generate tools and resources to facilitate ongoing use of CRIC data and biospecimens by a broad group of investigators, and (7) support UIC CRIC participant enrollment into the recently funded UIC Kidney Precision Medicine Project (KPMP) CKD Recruitment Site. During the first four phases of the CRIC Study, the UIC research team enrolled nearly 1,200 participants and has been successful in retention, protocol implementation, data quality, and scientific productivity. Additional noteworthy achievements include a strong focus on heath disparities in CKD, a significant number of UIC investigator-led publications, leadership on funded ancillary studies, and the promotion of new physician-scientists. Consequently, the UIC team is well positioned to make a substantive contribution to the consortium by generating new scientific output and successfully transitioning the CRIC Study from its active prospective cohort phase to a long-lasting resource for supporting ongoing and future mechanistic, epidemiologic, and translational investigations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $279,646 )
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	24	7/2/2024	NON-COMPETING CONTINUATION	$279,646
2024	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	23	1/17/2024	COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	10/31/2023	COMPETING CONTINUATION	$539,295
2024	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	10/31/2023	NON-COMPETING CONTINUATION	-$539,295
														Subtotal = $279,646

Issue Date FY: 2023 ( Subtotal = $299,631 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	7/28/2023	COMPETING CONTINUATION	$299,631
														Subtotal = $299,631

Issue Date FY: 2022 ( Subtotal = $571,523 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	7/21/2022	NON-COMPETING CONTINUATION	$571,523
2022	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	12/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $571,523

Issue Date FY: 2021 ( Subtotal = $592,065 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	7/1/2021	NON-COMPETING CONTINUATION	$592,065
														Subtotal = $592,065

Issue Date FY: 2020 ( Subtotal = $592,065 )
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	6/30/2020	NON-COMPETING CONTINUATION	$592,065
2020	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	3/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $592,065

Issue Date FY: 2019 ( Subtotal = $602,427 )
2019	2019	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	7/16/2019	NON-COMPETING CONTINUATION	$602,427
2019	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	2/5/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $602,427

Issue Date FY: 2018 ( Subtotal = $613,095 )
2018	2018	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	8/28/2018	COMPETING CONTINUATION	$613,095
2018	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	8/27/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $613,095

Issue Date FY: 2017 ( Subtotal = $635,000 )
2017	2017	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	6/19/2017	NON-COMPETING CONTINUATION	$635,000
2017	2016	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	11/16/2016	EXTENSION WITH OR WITHOUT FUNDS	$277,635
2017	2015	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	11/16/2016	NON-COMPETING CONTINUATION	-$139,508
2017	2015	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	15	11/16/2016	SUPPLEMENT FOR EXPANSION	-$138,127
														Subtotal = $635,000

Issue Date FY: 2016 ( Subtotal = $773,127 )
2016	2016	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	5/24/2016	EXTENSION WITH OR WITHOUT FUNDS	$773,127
														Subtotal = $773,127

Issue Date FY: 2015 ( Subtotal = $773,127 )
2015	2015	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	5/14/2015	NON-COMPETING CONTINUATION	$635,000
2015	2015	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	15	8/26/2015	SUPPLEMENT FOR EXPANSION	$138,127
														Subtotal = $773,127

Issue Date FY: 2014 ( Subtotal = $635,000 )
2014	2014	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	7/17/2014	NON-COMPETING CONTINUATION	$635,000
														Subtotal = $635,000

Issue Date FY: 2013 ( Subtotal = $635,000 )
2013	2013	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	13	8/16/2013	COMPETING CONTINUATION	$635,000
2013	2012	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	8/15/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $635,000

Issue Date FY: 2012 ( Subtotal = $769,540 )
2012	2012	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	7/19/2012	NON-COMPETING CONTINUATION	$636,731
2012	2012	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	9/4/2012	SUPPLEMENT FOR EXPANSION	$132,809
2012	2011	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	2/10/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $769,540

Issue Date FY: 2011 ( Subtotal = $772,096 )
2011	2011	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	9/2/2011	NON-COMPETING CONTINUATION	$772,096
														Subtotal = $772,096

Issue Date FY: 2010 ( Subtotal = $787,584 )
2010	2010	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	10	9/7/2010	SUPPLEMENT FOR EXPANSION	$140,853
2010	2010	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Kidney Diseases, Urology and Hematology Research	001	10	8/24/2010	NON-COMPETING CONTINUATION	$646,731
2010	2009	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Kidney Diseases, Urology and Hematology Research	000	9	12/8/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $787,584

Issue Date FY: 2009 ( Subtotal = $798,917 )
2009	2009	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Trans-NIH Recovery Act Research Support	002	9	9/21/2009	SUPPLEMENT FOR EXPANSION	$152,186
2009	2009	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Kidney Diseases, Urology and Hematology Research	001	9	9/2/2009	NON-COMPETING CONTINUATION	$646,731
2009	2008	UNIVERSITY OF ILLINOIS AT CHICAGO	890 SOUTH MARSHFIELD AVENUE	CHICAGO	IL	60612	COOK	USA	Kidney Diseases, Urology and Hematology Research	000	8	4/13/2009	COMPETING CONTINUATION	$0
														Subtotal = $798,917

Grand Total All Awards = $14,528,045

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Continuation of the University of Illinois Chicago CRIC Clinical Center

Award Number: U01DK060980

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/28/2001

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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