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Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study

Award Number: U01DK060963
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Chronic kidney disease (CKD) is an important public health challenge because it is a major risk factor for end-stage renal disease (ESRD), cardiovascular disease (CVD), and premature death. Understanding novel risk factors for the progression of CKD, CVD, and other related comorbidities may help to develop effective approaches for early intervention in order to reduce the adverse disease burden. The Chronic Renal Insufficiency Cohort (CRIC) Study is an NIDDK-sponsored multicenter prospective study designed to investigate novel risk factors for the progression of CKD and development of CVD among patients with CKD. The CRIC Study recruited 3,939 patients with CKD from 7 Clinical Centers in phase 1 and an additional 1,560 patients in phase 3. The CRIC Tulane Clinical Center recruited 405 participants in phase 1 and 253 participants in phase 3 and achieved the highest follow-up rate among all clinical centers despite the devastation caused by Hurricane Katrina in the New Orleans area. In CRIC phase 4, we propose to expand the study's scope to implement novel remote data capture technologies in sub-groups of study participants to determine sub-clinical acute declines in kidney function and to identify novel CVD phenotypes. Specific aims to be addressed in phase 4 by the Tulane Clinical Center are: 1. To re-enroll a high percentage of existing participants and obtain study data in these participants; 2. To maintain high levels of participant retention; 3. To identify novel CVD phenotypes using remotely collected data and determine their relationship to clinical outcomes; 4. To examine sub-clinical acute declines in kidney function using remotely collected data and determine their relationship to clinical outcomes; 5. To investigate self-reported CVD and renal events and obtain supporting medical records and documentation; 6. To implement effective local quality assurance and quality control procedures to ensure standardized, high-quality measurements; 7. To participate in governance and oversight of CRIC through study-wide subcommittees and activities; 8. To publish and present findings from the CRIC Study, including integrative and other high-impact manuscripts; 9. To conduct approved CRIC ancillary studies; 10. To utilize state-of-the-art methods in biostatistics and bioinformatics to analyze complex, longitudinal datasets incorporating a multitude of exposure and outcome variables; 11. To engage investigators at the Tulane Clinical Center to assist in local analysis of CRIC data, to develop and conduct ancillary studies, and to participate in parent study activities; and 12. To engage investigators in the broader scientific community to participate in the CRIC Study. The proposed research has important public health and clinical implications. The study findings may reveal novel and reversible underlying etiologic factors for the progression of CKD, CVD, and other related comorbid outcomes. This information will be useful to develop further intervention studies aimed at reducing total morbidity and mortality burdens among patients with CKD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	1/18/2024	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $259,582 )
2023	2023	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	8/1/2023	COMPETING CONTINUATION	$259,582
														Subtotal = $259,582

Issue Date FY: 2022 ( Subtotal = $565,378 )
2022	2022	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	7/21/2022	NON-COMPETING CONTINUATION	$565,378
														Subtotal = $565,378

Issue Date FY: 2021 ( Subtotal = $591,287 )
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	7/15/2021	NON-COMPETING CONTINUATION	$591,287
2021	2021	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	8/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $591,287

Issue Date FY: 2020 ( Subtotal = $591,287 )
2020	2020	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	20	7/1/2020	NON-COMPETING CONTINUATION	$591,287
2020	2018	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	18	2/20/2020	COMPETING CONTINUATION	$4,573
2020	2018	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	2/11/2020	COMPETING CONTINUATION	-$4,573
2020	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	2/18/2020	NON-COMPETING CONTINUATION	$0
2020	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	2/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $591,287

Issue Date FY: 2019 ( Subtotal = $565,378 )
2019	2019	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	19	7/16/2019	NON-COMPETING CONTINUATION	$565,378
2019	2018	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	4/12/2019	COMPETING CONTINUATION	$4,573
2019	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	4/12/2019	NON-COMPETING CONTINUATION	-$4,573
														Subtotal = $565,378

Issue Date FY: 2018 ( Subtotal = $565,378 )
2018	2018	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	8/29/2018	COMPETING CONTINUATION	$565,378
2018	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	8/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $565,378

Issue Date FY: 2017 ( Subtotal = $720,000 )
2017	2017	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	6/19/2017	NON-COMPETING CONTINUATION	$720,000
2017	2016	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	12/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$81,698
2017	2015	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	12/29/2016	NON-COMPETING CONTINUATION	-$81,698
														Subtotal = $720,000

Issue Date FY: 2016 ( Subtotal = $720,000 )
2016	2016	TULANE UNIVERSITY, SCHOOL OF MEDICINE	1430 TULANE AVENUE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	5/24/2016	EXTENSION WITH OR WITHOUT FUNDS	$720,000
														Subtotal = $720,000

Issue Date FY: 2015 ( Subtotal = $745,000 )
2015	2015	TULANE UNIVERSITY, SCHOOL OF MEDICINE	1430 TULANE AVENUE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	5/15/2015	NON-COMPETING CONTINUATION	$745,000
														Subtotal = $745,000

Issue Date FY: 2014 ( Subtotal = $670,000 )
2014	2014	TULANE UNIVERSITY, SCHOOL OF MEDICINE	1430 TULANE AVENUE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	6/20/2014	NON-COMPETING CONTINUATION	$670,000
														Subtotal = $670,000

Issue Date FY: 2013 ( Subtotal = $670,000 )
2013	2013	TULANE UNIVERSITY, SCHOOL OF MEDICINE	1430 TULANE AVENUE	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	13	8/16/2013	COMPETING CONTINUATION	$670,000
2013	2012	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	8/15/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $670,000

Issue Date FY: 2012 ( Subtotal = $672,461 )
2012	2012	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	6/6/2012	NON-COMPETING CONTINUATION	$672,461
														Subtotal = $672,461

Issue Date FY: 2011 ( Subtotal = $672,461 )
2011	2011	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	8/4/2011	NON-COMPETING CONTINUATION	$672,461
														Subtotal = $672,461

Issue Date FY: 2010 ( Subtotal = $682,461 )
2010	2010	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Kidney Diseases, Urology and Hematology Research	004	10	7/21/2010	NON-COMPETING CONTINUATION	$682,461
2010	2009	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Kidney Diseases, Urology and Hematology Research	000	9	2/3/2010	NON-COMPETING CONTINUATION	$0
2010	2009	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Trans-NIH Recovery Act Research Support	001	9	2/8/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2009	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Kidney Diseases, Urology and Hematology Research	003	9	3/29/2010	NON-COMPETING CONTINUATION	$0
2010	2009	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Trans-NIH Recovery Act Research Support	002	9	3/1/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $682,461

Issue Date FY: 2009 ( Subtotal = $788,707 )
2009	2009	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Kidney Diseases, Urology and Hematology Research	000	9	7/16/2009	NON-COMPETING CONTINUATION	$682,461
2009	2009	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Trans-NIH Recovery Act Research Support	001	9	9/2/2009	SUPPLEMENT FOR EXPANSION	$106,246
														Subtotal = $788,707

Issue Date FY: 2008 ( Subtotal = $702,021 ) (Continued on the next page)
2008	2008	TULANE UNIVERSITY OF LOUISIANA	6823 SAINT CHARLES STREET	NEW ORLEANS	LA	70118	ORLEANS	USA	Kidney Diseases, Urology and Hematology Research	001	7	3/28/2008	SUPPLEMENT FOR EXPANSION	$19,560
Grand Total All Awards = $13,371,738

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Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study

Award Number: U01DK060963

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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