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Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center

Award Number: U01DK060902
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Since 2002, the NIDDK has sponsored four phases of the prospective Chronic Renal Insufficiency Cohort (CRIC) Study, which enrolled a combined cohort of >5400 adults with chronic kidney disease (CKD) at seven Clinical Centers across the U.S. to address the overarching goals of identifying risk factors for CKD progression and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events, death, resource utilization and other patient-centered outcomes. The most recent Phase 4 (ending June 2023) has further innovated on remote data collection methods and more granular investigation of kidney function trajectories and cardiovascular sub-phenotypes across the spectrum of CKD severity. The proposed CRIC Phase 5 will leverage the cumulative experience, expertise and success of the CRIC Study network by creating mechanisms for future data collection and analyses and generating tools and resources for ongoing use of the extensive longitudinal CRIC data and biospecimens. CRIC Phase 5 will strengthen the existing unparalleled resource for the broader research community that will enhance the science related to CKD to achieve the ultimate goal of improving clinical and patient-centered outcomes. The Kaiser Permanente Northern California/University of California, San Francisco (KPNC/UCSF) Clinical Center has been a leader within the CRIC Study and the Specific Aims to be addressed in CRIC Phase 5 by the KPNC/UCSF Clinical Center are: 1. To complete clinical outcome ascertainment for the CRIC participants enrolled in the sub-protocols initiated during Phase 4, including in-home testing of kidney function and damage and ambulatory measures of cardiac arrhythmias and cardiovascular reserve 2. To complete follow-up of eligible CRIC participants 3. To conduct analyses that integrate the data collected through the Phase 4 sub-protocols with previously collected data and outcomes to identify novel risk factors and sub-phenotypes for CKD progression, cardiovascular and other outcomes 4. To facilitate linkages with external data sources to allow acquisition of additional data for future investigations 5. To transfer data and collect and ship biological specimens to the CRIC Scientific and Data Coordinating Center for transfer to NIDDK Central Repository to support future research 6. To promote dissemination of tools to facilitate the use of CRIC resources by investigators in the broader scientific community during and beyond the end of the CRIC Study


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $269,542 )
2024	2024	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	24	6/28/2024	NON-COMPETING CONTINUATION	$269,542
2024	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	4/9/2024	COMPETING CONTINUATION	$187,037
2024	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	4/9/2024	NON-COMPETING CONTINUATION	-$187,037
														Subtotal = $269,542

Issue Date FY: 2023 ( Subtotal = $289,106 )
2023	2023	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	7/28/2023	COMPETING CONTINUATION	$289,106
														Subtotal = $289,106

Issue Date FY: 2022 ( Subtotal = $769,609 )
2022	2022	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	7/8/2022	NON-COMPETING CONTINUATION	$769,609
2022	2021	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	2/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $769,609

Issue Date FY: 2021 ( Subtotal = $769,609 )
2021	2021	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	7/1/2021	NON-COMPETING CONTINUATION	$769,609
														Subtotal = $769,609

Issue Date FY: 2020 ( Subtotal = $769,609 )
2020	2020	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	6/29/2020	NON-COMPETING CONTINUATION	$769,609
2020	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	4/9/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $769,609

Issue Date FY: 2019 ( Subtotal = $769,609 )
2019	2019	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	19	7/16/2019	NON-COMPETING CONTINUATION	$769,609
2019	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	18	4/2/2019	COMPETING CONTINUATION	$0
2019	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	1/18/2019	COMPETING CONTINUATION	$31,995
2019	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	1/18/2019	NON-COMPETING CONTINUATION	-$31,995
														Subtotal = $769,609

Issue Date FY: 2018 ( Subtotal = $769,609 )
2018	2018	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	8/29/2018	COMPETING CONTINUATION	$769,609
2018	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	8/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $769,609

Issue Date FY: 2017 ( Subtotal = $925,000 )
2017	2017	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	6/19/2017	NON-COMPETING CONTINUATION	$925,000
2017	2016	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	11/18/2016	EXTENSION WITH OR WITHOUT FUNDS	$304,084
2017	2015	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	11/18/2016	NON-COMPETING CONTINUATION	-$304,084
														Subtotal = $925,000

Issue Date FY: 2016 ( Subtotal = $925,000 )
2016	2016	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	5/26/2016	EXTENSION WITH OR WITHOUT FUNDS	$925,000
														Subtotal = $925,000

Issue Date FY: 2015 ( Subtotal = $925,000 )
2015	2015	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	5/14/2015	NON-COMPETING CONTINUATION	$925,000
														Subtotal = $925,000

Issue Date FY: 2014 ( Subtotal = $925,000 )
2014	2014	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	7/17/2014	NON-COMPETING CONTINUATION	$925,000
														Subtotal = $925,000

Issue Date FY: 2013 ( Subtotal = $925,000 )
2013	2013	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	13	8/16/2013	COMPETING CONTINUATION	$925,000
2013	2012	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	8/15/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $925,000

Issue Date FY: 2012 ( Subtotal = $935,784 )
2012	2012	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	7/9/2012	NON-COMPETING CONTINUATION	$935,784
														Subtotal = $935,784

Issue Date FY: 2011 ( Subtotal = $935,784 )
2011	2011	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	8/19/2011	NON-COMPETING CONTINUATION	$935,784
														Subtotal = $935,784

Issue Date FY: 2010 ( Subtotal = $945,784 )
2010	2010	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	8/3/2010	NON-COMPETING CONTINUATION	$945,784
2010	2007	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Kidney Diseases, Urology and Hematology Research	000	7	3/10/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $945,784

Issue Date FY: 2009 ( Subtotal = $1,048,061 )
2009	2009	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Trans-NIH Recovery Act Research Support	002	9	9/21/2009	SUPPLEMENT FOR EXPANSION	$102,277
2009	2009	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	8/4/2009	NON-COMPETING CONTINUATION	$945,784
2009	2005	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Kidney Diseases, Urology and Hematology Research	000	5	9/29/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,048,061

Issue Date FY: 2008 ( Subtotal = $1,020,395 )
2008	2008	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Kidney Diseases, Urology and Hematology Research	000	8	9/3/2008	COMPETING CONTINUATION	$993,189
2008	2008	KAISER FOUNDATION RESEARCH INSTITUTE	1800 HARRISON, 16TH FLOOR	OAKLAND	CA	94612	ALAMEDA	USA	Kidney Diseases, Urology and Hematology Research	001	7	3/28/2008	SUPPLEMENT FOR EXPANSION	$27,206
														Subtotal = $1,020,395

Issue Date FY: 2007 ( Subtotal = $1,015,618 ) (Continued on the next page)
Grand Total All Awards = $18,601,686

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Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center

Award Number: U01DK060902

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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