Wednesday, January 15, 2025 1/15/2025

15/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center

Award Number: U01DK048387
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Abnormal regulation of glycemia (“dysglycemia”) has a very long time course, from the earliest stage of pre-diabetes, to the onset of Type 2 diabetes (T2D), to the development of clinically detectable microvascular changes and measurable atherosclerosis, to clinically manifest complications with attendant morbidity and mortality. The Diabetes Prevention Program (DPP) focused on the pre-diabetes stage of dysglycemia and demonstrated powerful beneficial effects of lifestyle intervention (ILS) and metformin (MET), compared with placebo (PLBO), in preventing or delaying the onset of T2D over a 3-year period in a high-risk population (n=3234). The DPP also investigated and described the interventions, phenotypic and genotypic risk factors associated with T2D development, the effects of the interventions in the setting of these risk factors, the health economic implications of T2D prevention, and other outcomes of interest. Based on these results, the DPP lifestyle program has been widely implemented. The DPP Outcomes Study (DPPOS) has explored the longer-term effects of T2D prevention in the DPP cohort, bridging the period between pre-diabetes and T2D, and has examined outcomes that required more time to develop than the 3-years of DPP. DPPOS showed longer-term salutary effects of the original interventions on T2D prevention and on cardiovascular disease (CVD) risk factors. The risk for microvascular disease was significantly greater in subjects who developed T2D and increased with longer duration and higher hemoglobin A1c (HbA1c). There were no significant differences by treatment group in the prevalence of the aggregate microvascular outcome; however, compared with PLBO and MET, ILS significantly reduced the risk of microvascular disease among women and those with HbA1c ≥6.5%. During the one-year extension of DPPOS Phase 3, we will maintain and continue to follow the well-characterized and valuable DPPOS cohort, and collect measurements of outcomes as described in the protocol. We will 1) perform new analyses to characterize the heterogeneous course of dysglycemia and its long-term complications and factors that define susceptibility or resistance to diabetes, its complications, and common chronic conditions of aging, and 2) explore the factors associated with participant retention, adherence to the protocol and completion of measurements, and determine if alternative methods can be implemented to improve retention and adherence and to expand data collection. These aims will provide important insights into prediabetes and diabetes and their long-term outcomes and could serve the potential further study of the DPPOS cohort.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$60,933 )
2024	2022	MEDSTAR HEALTH RESEARCH INSTITUTE INC	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	10/27/2023	SUPPLEMENT FOR EXPANSION	-$60,933
														Subtotal = -$60,933

Issue Date FY: 2022 ( Subtotal = $108,801 )
2022	2022	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	28	7/1/2022	SUPPLEMENT FOR EXPANSION	$108,801
2022	2021	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	2/14/2022	COMPETING CONTINUATION	$0
2022	2021	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	28	4/11/2022	COMPETING CONTINUATION	$0
														Subtotal = $108,801

Issue Date FY: 2021 ( Subtotal = $51,213 )
2021	2021	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	28	6/30/2021	COMPETING CONTINUATION	$582,499
2021	2021	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	3/5/2021	COMPETING CONTINUATION	$51,213
2021	2020	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	27	6/30/2021	NON-COMPETING CONTINUATION	-$476,772
2021	2019	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	26	6/30/2021	NON-COMPETING CONTINUATION	-$105,727
														Subtotal = $51,213

Issue Date FY: 2020 ( Subtotal = $476,772 )
2020	2020	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	27	2/19/2020	NON-COMPETING CONTINUATION	$35,767
2020	2020	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	27	1/30/2020	NON-COMPETING CONTINUATION	$441,005
														Subtotal = $476,772

Issue Date FY: 2019 ( Subtotal = $507,153 )
2019	2019	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	26	2/15/2019	NON-COMPETING CONTINUATION	$507,153
														Subtotal = $507,153

Issue Date FY: 2018 ( Subtotal = $491,948 )
2018	2018	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	4/19/2018	NON-COMPETING CONTINUATION	$49,195
2018	2018	MEDSTAR HEALTH RESEARCH INSTITUTE, INC.	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	1/31/2018	NON-COMPETING CONTINUATION	$442,753
														Subtotal = $491,948

Issue Date FY: 2017 ( Subtotal = $196,271 )
2017	2017	MED STAR HEALTH RESEARCH INSTITUTE	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	24	2/10/2017	NON-COMPETING CONTINUATION	$176,644
2017	2017	MED STAR HEALTH RESEARCH INSTITUTE	6525 BELCREST RD STE 700	HYATTSVILLE	MD	20782	PRINCE GEORGES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	24	6/16/2017	NON-COMPETING CONTINUATION	$19,627
														Subtotal = $196,271

Issue Date FY: 2016 ( Subtotal = $535,874 )
2016	2016	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	1/19/2016	COMPETING CONTINUATION	$469,722
2016	2016	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	23	6/15/2016	COMPETING CONTINUATION	$0
2016	2016	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	23	6/30/2016	SUPPLEMENT FOR EXPANSION	$24,682
2016	2016	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	6/2/2016	COMPETING CONTINUATION	$0
2016	2016	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	23	8/25/2016	SUPPLEMENT FOR EXPANSION	$41,470
														Subtotal = $535,874

Issue Date FY: 2015 ( Subtotal = $493,213 )
2015	2015	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	2/2/2015	COMPETING CONTINUATION	$493,213
2015	2015	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	3/19/2015	COMPETING CONTINUATION	$0
														Subtotal = $493,213

Issue Date FY: 2014 ( Subtotal = $533,983 )
2014	2014	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	3/26/2014	NON-COMPETING CONTINUATION	$533,983
														Subtotal = $533,983

Issue Date FY: 2013 ( Subtotal = $718,669 )
2013	2013	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	6/5/2013	NON-COMPETING CONTINUATION	$270,623
2013	2013	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	1/25/2013	NON-COMPETING CONTINUATION	$448,046
														Subtotal = $718,669

Issue Date FY: 2012 ( Subtotal = $575,770 )
2012	2012	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	8/29/2012	NON-COMPETING CONTINUATION	$21,574
2012	2012	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	3/5/2012	NON-COMPETING CONTINUATION	$554,196
														Subtotal = $575,770

Issue Date FY: 2011 ( Subtotal = $594,249 )
2011	2011	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	7/4/2011	NON-COMPETING CONTINUATION	$69,425
2011	2011	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	2/16/2011	NON-COMPETING CONTINUATION	$524,824
														Subtotal = $594,249

Issue Date FY: 2010 ( Subtotal = $387,019 )
2010	2010	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	2/19/2010	NON-COMPETING CONTINUATION	$387,019
														Subtotal = $387,019

Issue Date FY: 2009 ( Subtotal = $616,860 )
2009	2009	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	4/1/2009	COMPETING CONTINUATION	$616,860
2009	2008	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	4/1/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $616,860

Issue Date FY: 2008 ( Subtotal = $577,433 )
2008	2008	MEDSTAR RESEARCH INSTITUTE, INC	108 IRVING STREET, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	3/6/2008	NON-COMPETING CONTINUATION	$577,433
														Subtotal = $577,433

Issue Date FY: 2007 ( Subtotal = $400,317 ) (Continued on the next page)
Grand Total All Awards = $13,443,603

Page 1 of 2 (68 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

15/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center

Award Number: U01DK048387

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer