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Sequential Modeling for Prediction of Periodontal Diseases: an intra-Collaborative Practice-based Research study (ICPRS)

Award Number: U01DE033259
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Sequential Modeling for Prediction of Periodontal Diseases: an intra-Collaborative Practice-based Research study (ICPRS) - SUMMARY The Collaborative ICPRS clinically-oriented predoctoral/postdoctoral administered development current proposal titled “Sequential Modeling for Prediction of Periodontal Disea ses: An I ntra- Practice-Based Research Study ( ICPRS)” is developed in response to RFA-DE-23-012 . The will seek to develop various tasks in 4 component sections. In Component 1 , we seek to train 10 faculty from Temple University Kornberg School of Dentistry (TUKSoD) nd ten students in Applied Clinica l Research by offering a graduate certificate program by the College of Public Health (CPH) on facilitating skills in applied patient-oriented research a . The 15-credit certificate will focus . In Component 2, we aim to strengthen collaborations between TUKSoD, CPH and the Medical School for faculty and student training, and overall research support for the execution of Component 4 of this proposal. Our proposed project was collaboratively developed by individuals with backgrounds in Periodontology, General and Oral Epidemiology, Oral Microbiome, Health Informatics, Biostatistics and Public Health, and Physicians who will assist in extracting medical metrics relevant to management of periodontal diseases (PD) from real-time medical records in the Pennsylvania Health Share Exchange (PA HSX). In Component 3, we aim to expand clinically-oriented faculty participation in grant funded research activities, in the annual research day, and in national research meetings by increasing the number of faculty-student mentoring partnerships to conduct small-scale research projects. Finally, in Component 4, we will develop longitudinal predictive models of PD incidence and progression using machine learning approaches and microbiome/metagenomic sequencing strategies. This component has the following aims: Aim1 seeks to develop clinical decision tools that utilize matched medical-dental patient datasets from TUKSoD and the PA HSX EHR records. Aim1a will focus on developing a Medical Continuity of Care Record (CCR) that will provide patients' up-to-date medical health metrics that can be used in the provision of care at the dental school. Using dental patient's matched records, Aim1b will build an AI Empowered Prediction Model for PD. Aim2 will build on findings from Aim1b to assess the potential of the subgingival and salivary microbiomes as additional predictors of PD incidence and progression. Aim 2a will validate a dysbiosis index, applied to both subgingival plaque and saliva samples, as a predictor of PD in a cohort study, while Aim2b will identify potential high resolution, salivary/plaque metagenomic biomarkers of PD progression via a nested case-control study. The proposed application builds on prior research conducted at TUKSoD and is directed towards increasing participation of clinically-oriented faculty and pre/postdoctoral dental students in the school's research activities, coupled with training in Applied Clinical Research including health informatics, opening a new pathway to further research in dental education as well as promote faculty professional development, expand the research academic workforce, and provide opportunities to conduct student-mentored practice-based research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $765,985 )
2026	2026	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	4	7/21/2026	NON-COMPETING CONTINUATION	$765,985
														Subtotal = $765,985

Issue Date FY: 2025 ( Subtotal = $743,362 )
2025	2025	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	3	7/10/2025	NON-COMPETING CONTINUATION	$743,362
2025	2024	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	2	5/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $743,362

Issue Date FY: 2024 ( Subtotal = $710,819 )
2024	2024	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	2	7/31/2024	NON-COMPETING CONTINUATION	$710,819
2024	2023	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	1	6/25/2024	NEW	$0
														Subtotal = $710,819

Issue Date FY: 2023 ( Subtotal = $652,768 )
2023	2023	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	1	9/13/2023	NEW	$652,768
														Subtotal = $652,768

Grand Total All Awards = $2,872,934

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Sequential Modeling for Prediction of Periodontal Diseases: an intra-Collaborative Practice-based Research study (ICPRS)

Award Number: U01DE033259

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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