Thursday, July 3, 2025 7/3/2025

Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism

Award Number: U01DE028520
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/11/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism - Temporomandibular/orofacial pain disorders (TMD) are a group of painful conditions with multiple determinants. A number of psychosocial treatments for TMD have been developed, but overall effectiveness has been limited, and the mechanisms of treatment are unknown. This proposal has two main goals: 1) to develop a highly individualized, adaptive treatment for TMD that has potential to be more effective than other psychosocial treatments; and 2) to discover the mechanisms by which psychosocial treatments work in chronic pain. Patients with TMD-related pain of at least 3 months duration (N=160) will be randomly assigned to either a Standard Conservative Treatment +Cognitive Behavioral coping skills treatment (STD+CBT), or to an Individualized Assessment and cognitive- behavioral Treatment Program (IATP) for patients with TMD pain. Treatment in IATP will be based on a very detailed functional analysis of the patient's pain experience, in context, as derived from Experience Sampling (ES). The ES procedure will be conducted via smartphone app at a rate of 4 records per day, and will be used to gather information on patients' pain, momentary cognitions, affects, and coping behaviors, for a 2-week monitoring period prior to the beginning of treatment. Therapists will use this information to develop an individual functional analysis of pain and non-pain episodes, and determine what thoughts, feelings and actions are effective for that patient at managing pain and which are not. The information will be used to help develop adaptive coping tactics in a 6-session treatment program, offering skills training tailored to specific patient needs. During-treatment ES will allow adjustment of the treatment goals and procedures, making the treatment adaptive and able to change with changing circumstances and patient needs. This experimental treatment (IATP) will be added to a standard conservative splint-based treatment for TMD pain (STD). The combination (STD+IATP) will be compared to a STD treatment supplemented with a 6 session conventional cognitive-behavioral program not based on in-vivo assessment of pain and coping. In the STD+CBT condition ES data will be collected but will not be used to inform treatment, but will control for measurement reactivity. ES data collected prior to, during, and following both treatments (out to 12 months) will allow very precise measurement of cognitions, affects, and coping skills, as they occur in patients' home environments, and how they change over time. Outcomes will include measures of pain, interference, and depressive symptoms. The study will be able to tailor treatment based on patient experiences measured in near- real time at pain episodes, allow for adaptation of treatment as it progresses, and measure the impact on outcomes of coping changes over the long-term. The results will shed light on active mechanisms of treatment for TMD and may have implications for the management of other chronic pain conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$235,628 )
2025	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	000	5	11/6/2024	NON-COMPETING CONTINUATION	-$235,628
														Subtotal = -$235,628

Issue Date FY: 2024 ( Subtotal = $319,509 )
2024	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	000	5	2/1/2024	NON-COMPETING CONTINUATION	$568,937
2024	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	002	5	6/13/2024	NON-COMPETING CONTINUATION	$50,572
2024	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	003	5	7/1/2024	NON-COMPETING CONTINUATION	-$300,000
2024	2024	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	001	5	4/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $319,509

Issue Date FY: 2023 ( Subtotal = $664,651 )
2023	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	003	4	8/30/2023	NON-COMPETING CONTINUATION	$199,135
2023	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Oral Diseases and Disorders Research	004	4	9/1/2023	NON-COMPETING CONTINUATION	-$199,135
2023	2023	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	001	4	2/2/2023	NON-COMPETING CONTINUATION	$598,187
2023	2023	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	002	4	2/22/2023	NON-COMPETING CONTINUATION	$66,464
2023	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	000	3	11/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $664,651

Issue Date FY: 2022 ( Subtotal = $1,018,081 )
2022	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	002	3	8/30/2022	SUPPLEMENT FOR EXPANSION	$307,539
2022	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	001	3	5/4/2022	NON-COMPETING CONTINUATION	$64,596
2022	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	003	3	9/3/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	000	3	2/1/2022	NON-COMPETING CONTINUATION	$645,946
														Subtotal = $1,018,081

Issue Date FY: 2021 ( Subtotal = $738,102 )
2021	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	001	2	2/1/2021	NON-COMPETING CONTINUATION	$664,291
2021	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	002	2	2/22/2021	NON-COMPETING CONTINUATION	$73,811
2021	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	003	2	6/24/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	000	1	10/16/2020	NEW	$0
														Subtotal = $738,102

Issue Date FY: 2020 ( Subtotal = $748,865 )
2020	2020	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	001	1	7/30/2020	NEW	$0
2020	2020	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Oral Diseases and Disorders Research	000	1	2/11/2020	NEW	$748,865
														Subtotal = $748,865

Grand Total All Awards = $3,253,580

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Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism

Award Number: U01DE028520

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/11/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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