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Novel Dental Resin Composites with Improved Service Life

Award Number: U01DE023752
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2020

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Novel Dental Resin Composites with Improved Service Life - DESCRIPTION (provided by applicant): The short average service life of current dental composite restorative systems and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting dental materials having novel monomers and polymers, reinforcing fillers, and adhesive components. The goal of this proposed research is to develop novel dental composite systems, for use in restorations, sealants, and other dental services that are superior in properties and endurance to currently used Bis-GMA/TEGDMA and urethane-dimethacrylate systems. We will design and produce new monomers and their polymers that are not susceptible to enzymatic or hydrolytic degradation, establish a self- healing technique to significantly extend the fatigue lif of these composites, and formulate smart antibacterial components which are activated in the oral environment only when needed. We propose three specific aims that target these three key developments. In Specific Aim 1, we propose to improve durability by replacing the hydrolyzable ester groups, contained in current polymers and bonding agents, with hydrolytically stable ether groups in the corresponding polymers and bonding agents. In Specific Aim 2, we will develop self-healing dental composites (SHDC) that will autonomously repair micro-cracks that are hard to detect and almost impossible to repair clinically. Autonomic self-healing will significantly improve the durability of these materials by preventing catastrophic failures caused by thermal and mechanical challenges encountered in the oral environment. In Specific Aim 3, we propose to build a self-defense capability for the systems by incorporating nanoparticles functionalized with novel coupling agents that will release antimicrobial components only when exposed to bacterial attack or hydrolytic degradation. The integrity and durability of these novel systems wil be compared with Bis-GMA/TEGDMA based commercial systems under challenges like those that occur in the oral environment, including cariogenic biofilms, enzymatic degradations, thermal cycling fatigue and mechanical cycling fatigue. We expect that the novel materials, having features achieved by these three specific aims, will significantly surpass the performances of current Bis-GMA-TEGDMA-based commercial materials under these challenges. It is thus predictable that the new system will provide a significantly extended service life, at least by a factor of two. All of the features in the new system can be easily integrated into other restorative systems developed by the awardees of this U01-RFA, and can be used in composites and their dental adhesives. We plan to share our data and resources and collaborate with the awardees by way of all feasible procedure to achieve the goals of this program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$73,990 )
2023	2017	AMERICAN DENTAL ASSOCIATION FOUNDATION	211 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	5	10/1/2022	NON-COMPETING CONTINUATION	-$73,990
														Subtotal = -$73,990

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	AMERICAN DENTAL ASSOCIATION FOUNDATION	211 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	5	8/9/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	AMERICAN DENTAL ASSOCIATION FOUNDATION	211 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	5	9/20/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $428,735 )
2017	2017	AMERICAN DENTAL ASSOCIATION FOUNDATION	211 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	002	5	8/29/2017	NON-COMPETING CONTINUATION	$428,735
2017	2016	AMERICAN DENTAL ASSOCIATION FOUNDATION	211 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	001	4	4/8/2017	EXTENSION WITH OR WITHOUT FUNDS	$131,826
2017	2015	AMERICAN DENTAL ASSOCIATION FOUNDATION	211 E CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	3	4/8/2017	NON-COMPETING CONTINUATION	-$131,826
														Subtotal = $428,735

Issue Date FY: 2016 ( Subtotal = $429,878 )
2016	2016	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	4	8/17/2016	EXTENSION WITH OR WITHOUT FUNDS	$429,878
														Subtotal = $429,878

Issue Date FY: 2015 ( Subtotal = $437,044 )
2015	2015	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	3	9/3/2015	NON-COMPETING CONTINUATION	$437,044
														Subtotal = $437,044

Issue Date FY: 2014 ( Subtotal = $444,059 )
2014	2014	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	2	8/28/2014	NON-COMPETING CONTINUATION	$444,059
														Subtotal = $444,059

Issue Date FY: 2013 ( Subtotal = $449,747 )
2013	2013	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	1	9/1/2013	NEW	$449,747
														Subtotal = $449,747

Grand Total All Awards = $2,115,473

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Novel Dental Resin Composites with Improved Service Life

Award Number: U01DE023752

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2020

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