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Predicting Caries Lesion Patterns and Trajectories in Underserved Children, from Infancy to Early Adolescence, in Primary Healthcare Settings

Award Number: U01DE021412
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The recent NIDCR Oral Health in America report highlighted adolescence as a largely neglected life stage in oral health research and practice, with persistent and largely unchanged high caries experience, and called for strong actions to address this age cohort’s needs.1 Our team has been following a diverse cohort of children from age 1-9.5 years, and proposes now to follow them into early adolescence, providing a unique opportunity to assess U.S. children longitudinally culminating with much needed access and focus on adolescence. Given the large persistent disparities in caries rates and inequities in access to care for adolescents, targeted, risk-based healthcare delivery could be an important strategy to reduce disparities in adolescent health, while containing costs. The problem is that there have been almost no U.S. studies following the life-course progression of caries in children through adolescence to assess and predict caries patterns and disease trajectories over time, and relationships between these and changing oral and systemic health patterns in risk factors and behaviors. This is critical for targeting preventive, person-centered care in interprofessional settings that can adapt to changes in the life-course. The aims of this innovative U.S. study renewal are: 1) To define dental caries patterns (teeth and surfaces affected, e.g., pit-and-fissure vs. proximal, anterior vs. posterior) in early adolescence, including the trajectories of changes in caries patterns and counts (e.g., dmfs/DMFS) across the age-span (ages 1-15 years) (sub-aim 1a), in both primary and permanent teeth. 2) To identify patterns of caries risk factors and behaviors in the cohort when they were preschoolers (ages 1- 4), school-age (ages 6.5-9.5) and early adolescents (ages 12-15), and changes over time (sub-aim 2a). 3) To characterize the interplay among longitudinal caries patterns and risk factor/behavior patterns that lead to future caries development, we aim to develop risk screening tools to predict caries patterns, and predict caries incidence (sub-aim 3a), in early adolescence. This will be accomplished by following a diverse cohort of 500 primary caregiver (PCG)-child pairs enrolled in our ongoing U01 study. The PCGs will provide medical history and socio-demographic family information, while the adolescents will complete risk behavior questionnaires, and will have caries examinations at 12, 13.5 and 15 years of age to determine caries incidence, patterns, and trajectories. A great strength of this proposal is that it involves experienced medical/nursing and dental research groups, who have successfully worked together for the past 11 years and can facilitate follow-up of the cohort, while bringing new expertise in adolescent and behavioral health, and clinical decision-making. The overall impact and significance of this interdisciplinary project is that accurate risk stratification can optimize cost-effectiveness of personalized care, policy development, and public health planning. We will also be able to identify targets for intervention, and relationships with systemic health risk factors and comorbidities that can impact how we intervene to provide collaborative interprofessional care to improve adolescents' health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	13	11/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,718,950 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	006	13	6/13/2024	NON-COMPETING CONTINUATION	$140,323
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	005	13	3/22/2024	NON-COMPETING CONTINUATION	$1,578,627
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	003	12	11/8/2023	COMPETING CONTINUATION	$1,349,541
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	004	12	12/26/2023	COMPETING CONTINUATION	$0
2024	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	002	11	11/8/2023	SUPPLEMENT FOR EXPANSION	-$31,057
2024	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	11	11/8/2023	NON-COMPETING CONTINUATION	-$1,316,691
2024	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	10	11/8/2023	SUPPLEMENT FOR EXPANSION	-$1,793
														Subtotal = $1,718,950

Issue Date FY: 2023 ( Subtotal = $1,846,431 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	003	12	3/15/2023	COMPETING CONTINUATION	$1,846,431
2023	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	11	11/10/2022	NON-COMPETING CONTINUATION	$0
2023	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	11	3/8/2023	NON-COMPETING CONTINUATION	$0
2023	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	002	11	3/8/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,846,431

Issue Date FY: 2021 ( Subtotal = $1,587,379 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	003	11	7/27/2021	SUPPLEMENT FOR EXPANSION	$31,057
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	10	3/29/2021	SUPPLEMENT FOR EXPANSION	$7,582
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	002	11	7/26/2021	NON-COMPETING CONTINUATION	$1,548,740
2021	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	10	6/25/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,587,379

Issue Date FY: 2020 ( Subtotal = $1,774,484 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	10	7/7/2020	NON-COMPETING CONTINUATION	$1,774,484
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	9	4/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,774,484

Issue Date FY: 2019 ( Subtotal = $1,916,239 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	9	7/11/2019	NON-COMPETING CONTINUATION	$1,738,239
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	002	9	7/25/2019	SUPPLEMENT FOR EXPANSION	$178,000
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	8	4/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,916,239

Issue Date FY: 2018 ( Subtotal = $1,690,682 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	002	8	7/25/2018	NON-COMPETING CONTINUATION	$1,690,682
2018	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	7	4/9/2018	COMPETING CONTINUATION	$1,150,102
2018	2016	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	6	4/9/2018	EXTENSION WITH OR WITHOUT FUNDS	-$1,150,102
														Subtotal = $1,690,682

Issue Date FY: 2017 ( Subtotal = $1,957,145 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	005	7	9/11/2017	COMPETING CONTINUATION	$1,957,145
2017	2016	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	004	6	9/7/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2016	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	003	6	3/30/2017	EXTENSION WITH OR WITHOUT FUNDS	$1,615,278
2017	2015	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	002	5	3/30/2017	NON-COMPETING CONTINUATION	-$750,165
2017	2014	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	4	3/30/2017	NON-COMPETING CONTINUATION	-$790,427
2017	2013	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	3/30/2017	NON-COMPETING CONTINUATION	-$74,686
														Subtotal = $1,957,145

Issue Date FY: 2016 ( Subtotal = $750,165 )
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	6	7/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$750,165
														Subtotal = $750,165

Issue Date FY: 2015 ( Subtotal = $750,165 )
2015	2015	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	5	7/24/2015	NON-COMPETING CONTINUATION	$750,165
														Subtotal = $750,165

Issue Date FY: 2014 ( Subtotal = $790,427 )
2014	2014	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	4	7/30/2014	NON-COMPETING CONTINUATION	$790,427
														Subtotal = $790,427

Issue Date FY: 2013 ( Subtotal = $694,023 )
2013	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	3	7/10/2013	NON-COMPETING CONTINUATION	$694,023
														Subtotal = $694,023

Issue Date FY: 2012 ( Subtotal = $2,492,717 )
2012	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	001	2	7/30/2012	NON-COMPETING CONTINUATION	$2,490,958
2012	2011	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Oral Diseases and Disorders Research	000	1	3/27/2012	NEW	$1,759
														Subtotal = $2,492,717

Issue Date FY: 2011 ( Subtotal = $2,642,700 ) (Continued on the next page)
Grand Total All Awards = $20,611,507

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Predicting Caries Lesion Patterns and Trajectories in Underserved Children, from Infancy to Early Adolescence, in Primary Healthcare Settings

Award Number: U01DE021412

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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