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Component A: MD CADDRE: Study to Explore Early Development, SEED Phase III

Award Number: U01DD001214
ORGANIZATION: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES (NCBDDD)
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Component A: MD CADDRE: Study to Explore Early Development, SEED Phase III - Autism Spectrum Disorder (ASD) is a severe, life-long neurodevelopmental disorder that is associated with considerable impairment for individuals and a substantial burden to their families and communities. Little is known about the causes or correlates of ASD. While diagnostic practices are improving ASD identification, much remains to be discovered about risk and protective factors for ASD and about the phenotypic variation and prevalence of co-morbid conditions. In response to growing concerns, the Children’s Health Act of 2000 mandated CDC to establish ASD surveillance and research programs that address the magnitude, incidence, and causes of ASD and related developmental disabilities. The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDREs) were established at six national sites (California, Colorado, Georgia, Maryland, North Carolina, and Pennsylvania) to fulfill this mandate and are currently carrying out the second phase of the Study to Explore Early Development (SEED), a population-based case- control study. SEED addresses hypotheses including: ASD phenotypic variation, including clustering of core symptoms, cognitive status, and presence of co-morbidities; gastrointestinal features; genetic variation and gene-environment interaction (GxE); infection, immune function, and autoimmunity factors; and hormonal factors and maternal reproductive characteristics. Data collection includes developmental assessments and pre- and perinatal health and environment via interviews, medical record review, self-administered questionnaires, and biologic samples. As of December 2015, SEED 1 & 2 had completed data collection on 4652 families - 1341 with ASD, 1722 with other developmental disorders, and 1589 controls. This proposal seeks to carry out SEED 3, collecting another 625 children in each study group. This increased, combined sample size will enable well-powered assessment of SEED hypotheses, particularly for phenotypic subgroups and GxE interactions. Given the experience of SEED 1 & 2 and the infrastructure in place at each CADDRE site, SEED 3 can be quickly implemented, creating a combined SEED sample of clinical, risk factor, and biological specimens and data on over 6500 families. SEED would be the largest study of ASD of this kind, making significant contributions to our understanding of the complex autism phenotype and identifying potential risk and protective factors for ASD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$114,929 )
2023	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	10/11/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$114,929
2023	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	10/11/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	10/11/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	10/11/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2016	JOHNS HOPKINS UNIVERSITY, THE	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	02	5	10/11/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$114,929

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	Johns Hopkins University, The	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	01	5	6/21/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,020,377 )
2020	2020	Johns Hopkins University, The	1101 E. 33rd St., Ste B001	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	00	5	5/29/2020	NON-COMPETING CONTINUATION	$1,020,377
														Subtotal = $1,020,377

Issue Date FY: 2019 ( Subtotal = $1,020,377 )
2019	2019	Johns Hopkins University, The	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	01	4	6/24/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2019	Johns Hopkins University, The	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	00	4	6/11/2019	NON-COMPETING CONTINUATION	$1,020,377
														Subtotal = $1,020,377

Issue Date FY: 2018 ( Subtotal = $1,020,377 )
2018	2018	Johns Hopkins University, The	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	01	3	9/5/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2018	2018	Johns Hopkins University, The	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	00	3	7/1/2018	NON-COMPETING CONTINUATION	$1,020,377
2018	2017	Johns Hopkins University, The	3400 N Charles St	Baltimore	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	01	2	5/22/2018	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $1,020,377

Issue Date FY: 2017 ( Subtotal = $1,100,000 )
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	2	6/26/2017	NON-COMPETING CONTINUATION	$1,100,000
														Subtotal = $1,100,000

Issue Date FY: 2016 ( Subtotal = $1,009,813 )
2016	2016	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	002	1	9/9/2016	NEW	$0
2016	2016	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	000	1	7/4/2016	NEW	$1,009,813
2016	2016	JOHNS HOPKINS UNIVERSITY	1101 E 33RD STREET, STE-C-210	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Centers for Disease Control and Prevention Investigations and Technical Assistance	001	1	7/11/2016	NEW	$0
														Subtotal = $1,009,813

Grand Total All Awards = $5,056,015

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Component A: MD CADDRE: Study to Explore Early Development, SEED Phase III

Award Number: U01DD001214

ORGANIZATION: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES (NCBDDD)

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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