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Single-neuron population dynamics in human speech motor cortex for a speech prosthesis

Award Number: U01DC019430
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/02/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Single-neuron population dynamics in human speech motor cortex for a speech prosthesis - PROJECT SUMMARY Augmentative and alternative communication (AAC) technology for people with severe speech and motor impairment (SSMI) continues to improve, with recent advances being made in the neural control of communication devices. In prior NIDCD-supported research, our research team developed a high-performance intracortical brain-computer interface (iBCI) that decodes arm movement intentions directly from brain activity. This technology has allowed people with SSMI to control a computer cursor with sufficient speed and accuracy to type at up to 8 words/min and has enabled full control of unmodified consumer devices using only decoded motor cortical activity. In the proposed U01 clinical research, performed as part of the multi-site BrainGate consortium, we will build upon decades of experience in studying the motor system in humans and non-human primates, with the end goal of advancing iBCI technology. The goals of this project are to study how speech is prepared and produced at the level of ensembles of single neurons in speech-related motor areas of the brain in people with amyotrophic lateral sclerosis (ALS), and to create a speech prosthesis that will allow communication at rates approaching conversational speech (120-150 words per minute). We will approach these investigations with a suite of advanced methods, including (1) newly-developed dynamical systems computational approaches that have provided fundamental insights into the function of the motor system, and (2) machine learning algorithms for decoding of movement intention and language modeling that have formed the basis of the fastest communication prosthesis yet reported. Finally, we will continue to evaluate the safety profile of Utah-array based iBCIs through the ongoing BrainGate2 pilot clinical trial. Upon completion, this project will advance both the capabilities of iBCIs for communication and our understanding of the detailed neural mechanisms of speech production.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,106,092 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	4	8/27/2024	NON-COMPETING CONTINUATION	$1,106,092
														Subtotal = $1,106,092

Issue Date FY: 2023 ( Subtotal = $1,099,103 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	003	3	8/18/2023	NON-COMPETING CONTINUATION	$1,099,103
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	004	3	8/25/2023	NON-COMPETING CONTINUATION	$0
2023	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	002	2	6/13/2023	NON-COMPETING CONTINUATION	$0
2023	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	2	3/21/2023	NON-COMPETING CONTINUATION	$0
2023	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	2	6/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,099,103

Issue Date FY: 2022 ( Subtotal = $1,133,235 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	001	2	8/18/2022	NON-COMPETING CONTINUATION	$1,134,555
2022	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	1	10/15/2021	NEW	-$1,320
														Subtotal = $1,133,235

Issue Date FY: 2021 ( Subtotal = $1,052,160 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research Related to Deafness and Communication Disorders	000	1	8/2/2021	NEW	$1,052,160
														Subtotal = $1,052,160

Grand Total All Awards = $4,390,590

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Single-neuron population dynamics in human speech motor cortex for a speech prosthesis

Award Number: U01DC019430

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/02/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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