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Coding in Auditory Neurons: Effects of Amino Acids

Award Number: U01DC000151
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1979
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Coding in Auditory Neurons: Effects of Amino Acids - PROJECT SUMMARY Age-related hearing loss (ARHL) is a complex disorder affecting between 50-70% of the United States population aged 65 or older. In public settings, seniors frequently have great difficulty understanding speech, which can lead to withdrawal from social activities, depression and cognitive decline. All individuals and especially the elderly can maintain speech understanding in difficult listening conditions by engaging attentional, cognitive and mnemonic (top-down) resources to help disambiguate speech from a degraded ascending acoustic code. Understanding the impact of aging on circuits that maintain speech understanding and the pharmacology of cholinergic attentional systems in their modulation is at the core of the proposed studies. Studies during the previous grant period identified differential age-related changes in nicotinic cholinergic receptor (nAChR) subunit/subtypes in the medial geniculate body (MGB) and primary auditory cortex (AI). In vitro aging studies detailed the pre- and postsynaptic function of nAChRs in thalamic circuits likely to underpin attentional modulation of acoustic information. Unit recordings from awake rat auditory thalamus MGB also showed age-related repetition-enhancement, as opposed to sensory adaptation, in response to repeating/predictable temporally rich stimuli. This was posited to reflect increased use of corticofugal/higher- order resources. Age-related enhanced coding of repeating modulated stimuli was reproduced in young animals by simply degrading the temporal clarity of the sinusoidal amplitude modulated (SAM) stimuli. Corticothalamic blockade of projections to MGB reversed predictive repetition-enhancement to a degree, but not completely. The proposed Specific Aims will address questions raised by these prior studies and supported by preliminary data. In vitro and in vivo approaches in rats will: SA1: Characterize the functional pharmacology and the impact of aging on nAChR pharmacology in the central and dorsal nuclei of the inferior colliculus (CNIC, ENIC and DNIC). SA2A: Determine single unit response properties of CNIC and DNIC units to temporally distinct and less temporally distinct SAM stimuli presented in repeating/predictable or random sequences. SA2B: Determine the impact of aging on the response properties of CNIC and DNIC units to repeating vs. randomly presented SAM stimuli. SA3. Determine the impact of pontine mesencephalic tegmentum (PMT) release of acetylcholine on the response properties of IC units to temporally distinct and temporally less distinct SAM stimuli presented in a repeating or random sequences. Understanding the mechanisms involved in repetition enhancement/predictive coding and identification of novel nAChR subtypes potentially resistant to aging will inform future behavioral and pharmacotherapeutic approaches to improve speech understanding in the elderly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $493,870 )
2025	2025	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	002	40	9/17/2025	NON-COMPETING CONTINUATION	$0
2025	2025	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	000	40	1/17/2025	NON-COMPETING CONTINUATION	$444,484
2025	2025	SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE	801 N RUTLEGE	SPRINGFIELD	IL	62794	SANGAMON	USA	Research Related to Deafness and Communication Disorders	001	40	5/6/2025	NON-COMPETING CONTINUATION	$49,386
														Subtotal = $493,870

Grand Total All Awards = $493,870

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Coding in Auditory Neurons: Effects of Amino Acids

Award Number: U01DC000151

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1979

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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