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Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDS

Award Number: U01DA038886
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDS - PROJECT SUMMARY / ABSTRACT This competing renewal U01 application proposes an investigation of the impact of rapidly evolving substance use patterns on HIV prevention and HIV-associated co-morbidities. We propose to undertake this work in Vancouver, Canada, where, as in many areas in the US, exponential growth in synthetic opioid use has become a health crisis. Accordingly, we seek to characterize emerging drug use patterns and the associated impacts on engagement in HIV prevention and medication assisted treatments for opioid use disorder (MAT). We also aim to assess willingness to use, uptake of, and adherence to new and emerging HIV-focused biomedical interventions (e.g., pre-exposure prophylaxis [PrEP], microbicides). In Vancouver, PrEP has recently been made available at no cost to those at high risk of HIV acquisition, including people who inject drugs (PWID). We further aim to examine key HIV-associated co-morbidities, in particular pain and neurocognitive impairment, among a combined sample of HIV-negative and HIV-positive PWID and the related impacts on substance use patterns, engagement in HIV prevention and MAT. This project involves the continuation of the Vancouver Drug Users Study (V-DUS; n = 1800), which is one of the longest-running prospective cohort studies of community-recruited people who use illicit drugs (PWUD) internationally. The V-DUS is comprised of two nested cohorts following HIV-negative street-involved drug-using youth aged 14-26 years and HIV-negative adult PWID since 1996. Our study setting is a key innovative feature of the proposed work. Vancouver is a port city that continues to experience high availability and prevalent use of a wide range of illicit drugs. It is home to one of the most dramatic outbreaks of HIV among PWID and is now an epicenter of the ongoing synthetic opioid epidemic. In response, a range of pioneering policies and programs specific to illicit drug use have been introduced, and several of these are now being scaled up and/or considered in the US. For example, a broad set of MAT are available for virtually free of charge through the universal healthcare plan and in a low threshold manner, which allows us to examine MAT-related outcomes without the confounding effects of insurance schemes and programmatic barriers associated with high-threshold provision of MAT. The V-DUS is also a member of the C3PNO consortium and thereby ideally positioned to advance team science approaches. V-DUS has been highly productive and is a globally unique, valuable resource for advancing HIV research and training future HIV researchers. During the past grant cycle, >130 of >160 peer-reviewed publications have been led by >70 trainees. The V-DUS is also harmonized with an ongoing NIDA-funded cohort of HIV-positive PWUD and therefore a key control/comparison in work focused on HIV/AIDS among PWUD is possible. Given our environment and track record to date, we are well positioned to generate important scientific evidence on HIV prevention and HIV- associated co-morbidities thereby contributing to high and medium research priorities identified by the NIH Office of AIDS Research and informing efforts to end the HIV/AIDS pandemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	10	4/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,361,945 )
2024	2024	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	10	5/10/2024	NON-COMPETING CONTINUATION	$1,361,945
														Subtotal = $1,361,945

Issue Date FY: 2023 ( Subtotal = $1,298,700 )
2023	2023	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	005	9	5/16/2023	NON-COMPETING CONTINUATION	$1,298,700
2023	2023	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	006	9	6/28/2023	NON-COMPETING CONTINUATION	$0
2023	2020	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	004	6	1/17/2023	COMPETING CONTINUATION	$13,889
2023	2020	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DRIVE	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	001	6	11/18/2022	COMPETING CONTINUATION	-$526,421
2023	2019	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Drug Use and Addiction Research Programs	000	5	11/18/2022	NON-COMPETING CONTINUATION	$231,464
2023	2019	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Drug Use and Addiction Research Programs	003	5	1/17/2023	NON-COMPETING CONTINUATION	-$13,889
2023	2019	THE UNIVERSITY OF BRITISH COLUMBIA	224-6328 MEMORIAL RD	VANCOUVER	BC			CAN	Drug Use and Addiction Research Programs	002	5	11/18/2022	SUPPLEMENT FOR EXPANSION	$294,957
														Subtotal = $1,298,700

Issue Date FY: 2022 ( Subtotal = $1,361,945 )
2022	2022	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DR SUITE 1200	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	8	4/29/2022	NON-COMPETING CONTINUATION	$1,361,945
														Subtotal = $1,361,945

Issue Date FY: 2021 ( Subtotal = $1,825,121 )
2021	2021	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DR SUITE 1200	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	001	7	3/30/2021	NON-COMPETING CONTINUATION	$0
2021	2021	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DR SUITE 1200	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	000	7	3/12/2021	NON-COMPETING CONTINUATION	$1,298,700
2021	2020	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DR SUITE 1200	BURNABY	BC			CAN	Drug Use and Addiction Research Programs	002	6	6/10/2021	COMPETING CONTINUATION	$526,421
														Subtotal = $1,825,121

Issue Date FY: 2020 ( Subtotal = $861,759 )
2020	2020	SIMON FRASER UNIVERSITY	8888 UNIVERSITY DR SUITE 1200	BURNABY	BC	V5A 1S6		CAN	Drug Use and Addiction Research Programs	005	6	4/17/2020	COMPETING CONTINUATION	$1,388,180
2020	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	004	5	4/16/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	002	5	3/3/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	000	5	2/28/2020	NON-COMPETING CONTINUATION	-$231,464
2020	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	001	5	2/28/2020	SUPPLEMENT FOR EXPANSION	-$294,957
2020	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	003	5	4/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $861,759

Issue Date FY: 2019 ( Subtotal = $1,268,222 )
2019	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	001	5	9/17/2019	SUPPLEMENT FOR EXPANSION	$294,957
2019	2019	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	000	5	11/21/2018	NON-COMPETING CONTINUATION	$973,265
														Subtotal = $1,268,222

Issue Date FY: 2018 ( Subtotal = $1,018,330 )
2018	2018	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	001	4	4/26/2018	NON-COMPETING CONTINUATION	$101,832
2018	2018	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	000	4	12/1/2017	NON-COMPETING CONTINUATION	$916,498
														Subtotal = $1,018,330

Issue Date FY: 2017 ( Subtotal = $1,128,026 )
2017	2017	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	002	3	5/22/2017	NON-COMPETING CONTINUATION	$102,803
2017	2017	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	001	3	1/27/2017	SUPPLEMENT FOR EXPANSION	$100,000
2017	2017	UNIVERSITY OF BRITISH COLUMBIA, THE	6190 AGRONOMY RD STE 102	VANCOUVER	BC	V6T 1Z3		CAN	Drug Use and Addiction Research Programs	000	3	11/29/2016	NON-COMPETING CONTINUATION	$925,223
														Subtotal = $1,128,026

Issue Date FY: 2016 ( Subtotal = $1,132,515 )
2016	2016	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Drug Use and Addiction Research Programs	001	2	2/22/2016	SUPPLEMENT FOR EXPANSION	$99,997
2016	2016	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Drug Use and Addiction Research Programs	000	2	11/19/2015	NON-COMPETING CONTINUATION	$938,653
2016	2016	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Drug Use and Addiction Research Programs	002	2	3/8/2016	NON-COMPETING CONTINUATION	$93,865
														Subtotal = $1,132,515

Issue Date FY: 2015 ( Subtotal = $860,851 )
2015	2015	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Drug Use and Addiction Research Programs	001	1	8/25/2015	SUPPLEMENT FOR EXPANSION	$94,581
2015	2015	UNIVERSITY OF BRITISH COLUMBIA	2329 West Mall	VANCOUVER, B C				CAN	Drug Use and Addiction Research Programs	000	1	1/30/2015	NEW	$766,270
														Subtotal = $860,851

Grand Total All Awards = $12,117,414

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Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDS

Award Number: U01DA038886

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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