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The RADAR cohort study of multilevel Influences on HIV and substance use

Award Number: U01DA036939
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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The RADAR cohort study of multilevel Influences on HIV and substance use - We propose to continue the largest cohort study of young men in the Unites States with a very high HIV incidence. RADAR was launched in 2015 (renewed in 2020) to provide critical insights into risk and protective factors for HIV and drug use, and to identify facilitators and barriers to the implementation of effective strategies to end the epidemics of substance use and HIV among young men. RADAR is reflective of the US HIV epidemic; it focuses on the ages with the highest HIV and substance use disorder incidence, has exceptional representation of those most affected, and is located in the urban epicenter of the HIV and drug epidemics in the Midwest (i.e., Chicago/Cook County-4th highest incidence in US). We have been extremely productive in recruitment (N=1,357), retention (>80%), scientific outputs (113+ publications), and serving as a platform for additional innovative research (4 Fs, 4 Ks, 10 Rs, 50+ connected studies; 10 concepts via NIDA consortium). High-risk young men, such as those in our sample, account for 75% of all new HIV diagnoses among adolescents and young adults in the US and have not seen the declines found in other age groups. Substance use and multi-level health challenges (i.e., limited health knowledge or pre-existing psychological/biological factors) are key drivers HIV acquisition in this group. We propose a sophisticated multilevel research design, in which we will enhance the cohort with 600 new participants and continue to follow existing cohort members into their 30s and 40s. We will answer critical new questions about the substance use epidemics that drive the HIV epidemic and non-AIDS comorbidities. Aim 1: we will keep a pulse on emerging trends in drug use, HIV risk/preventive behaviors, and care continuum engagement. We will chart trajectories and multilevel risk/protective factors for substance use and HIV outcomes. Aim 2: RADAR will investigate the impact of health challenges, HIV, and substance use on key aging-related biological mechanisms and their impacts on vascular health and cognitive function comorbidities among young men living with and without HIV. Aim 3: we will engage in regular dialogue with key stakeholders, conduct implementation research, and disseminate findings directly to end-users to close research-to-practice gaps. Aim 4: RADAR will continue to add specimens and data to our large and well-characterized biobehavioral repository to provide a platform for high-impact science, and we will maintain existing collaborations. RADAR is a unique multilevel and longitudinal study of young men with a very high observed HIV incidence. The multi-cohort design (youth enrolled in 2008, 2011, 2015, 2020, now) provides a powerful design for examining trajectories and predictors while staying attuned to historical/generational differences–its continuation is critical to informing approaches to ending the substance us and HIV epidemics in all young men.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,879,693 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	12	4/6/2026	NON-COMPETING CONTINUATION	$2,879,693
2026	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	10	3/18/2026	OTHER REVISION	$0
														Subtotal = $2,879,693

Issue Date FY: 2025 ( Subtotal = $2,844,399 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	003	11	8/14/2025	COMPETING CONTINUATION	$2,844,399
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	10	3/21/2025	TERMINATION	$0
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	004	10	8/15/2025	OTHER REVISION	$0
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	002	10	7/3/2025	OTHER REVISION	$0
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	10	6/27/2025	OTHER REVISION	$0
														Subtotal = $2,844,399

Issue Date FY: 2024 ( Subtotal = $2,747,259 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	002	10	5/2/2024	NON-COMPETING CONTINUATION	$274,725
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	10	3/1/2024	NON-COMPETING CONTINUATION	$0
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	10	2/3/2024	NON-COMPETING CONTINUATION	$2,472,534
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	003	10	6/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,747,259

Issue Date FY: 2023 ( Subtotal = $2,787,706 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	9	1/18/2023	SUPPLEMENT FOR EXPANSION	$41,664
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	9	1/13/2023	NON-COMPETING CONTINUATION	$2,746,042
														Subtotal = $2,787,706

Issue Date FY: 2022 ( Subtotal = $2,864,607 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	8	3/2/2022	NON-COMPETING CONTINUATION	$2,465,654
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	002	8	3/30/2022	NON-COMPETING CONTINUATION	$273,961
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	004	8	5/18/2022	NON-COMPETING CONTINUATION	$0
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	8	3/3/2022	SUPPLEMENT FOR EXPANSION	$112,493
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	003	8	3/31/2022	SUPPLEMENT FOR EXPANSION	$12,499
														Subtotal = $2,864,607

Issue Date FY: 2021 ( Subtotal = $3,007,680 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	002	7	8/10/2021	SUPPLEMENT FOR EXPANSION	$82,937
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	7	2/9/2021	NON-COMPETING CONTINUATION	$2,915,207
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	7	5/21/2021	SUPPLEMENT FOR EXPANSION	$9,536
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	003	7	9/1/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,007,680

Issue Date FY: 2020 ( Subtotal = $2,842,587 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	6	3/16/2020	COMPETING CONTINUATION	$2,685,262
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	003	6	9/18/2020	COMPETING CONTINUATION	$937
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	004	6	9/25/2020	SUPPLEMENT FOR EXPANSION	$157,325
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	002	5	9/18/2020	SUPPLEMENT FOR EXPANSION	-$937
2020	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	5	3/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,842,587

Issue Date FY: 2019 ( Subtotal = $873,270 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	5	3/5/2019	SUPPLEMENT FOR EXPANSION	$873,270
														Subtotal = $873,270

Issue Date FY: 2018 ( Subtotal = $1,861,543 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	003	5	9/7/2018	NON-COMPETING CONTINUATION	$0
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	5	4/26/2018	NON-COMPETING CONTINUATION	$185,309
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	5	3/16/2018	NON-COMPETING CONTINUATION	$1,667,767
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	002	5	5/7/2018	SUPPLEMENT FOR EXPANSION	$8,467
														Subtotal = $1,861,543

Issue Date FY: 2017 ( Subtotal = $1,853,715 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	4	3/21/2017	NON-COMPETING CONTINUATION	$1,668,342
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	4	5/22/2017	NON-COMPETING CONTINUATION	$185,373
														Subtotal = $1,853,715

Issue Date FY: 2016 ( Subtotal = $1,655,401 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	001	3	5/16/2016	SUPPLEMENT FOR EXPANSION	$5,767
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	3	3/18/2016	NON-COMPETING CONTINUATION	$1,649,634
														Subtotal = $1,655,401

Issue Date FY: 2015 ( Subtotal = $1,664,058 )
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Drug Use and Addiction Research Programs	000	2	4/1/2015	NON-COMPETING CONTINUATION	$1,664,058
														Subtotal = $1,664,058

Issue Date FY: 2014 ( Subtotal = $1,634,901 ) (Continued on the next page)
Grand Total All Awards = $29,516,819

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The RADAR cohort study of multilevel Influences on HIV and substance use

Award Number: U01DA036939

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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