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Using Longitudinal Research to Engage African American and Latinx Sexual- and Gender-Minority Youth in the HIV Prevention and Care Continua and Reduce HIV/AIDS-Related Disparities

Award Number: U01DA036926
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The U.S. has set a goal to end the HIV epidemic by the year 2030, which can be achieved but only if targeted approaches are implemented with at-risk populations to address known barriers of engagement along the HIV prevention and care continua. Populations of greatest concern include young men who have sex with men (YMSM), especially YMSM of color, who now account for the vast majority of new HIV infections each year. Transgender and gender non-conforming/non-binary youth are also at high risk for HIV acquisition, accounting for an increasing proportion of new infections each year. In 2015, we were awarded a grant from NIDA to establish a new cohort of 448 African American/Black (AA/B) and Latino YMSM, called the Healthy Young Men’s (HYM) Cohort. We also received an administrative supplement to collect two waves of data from a smaller cohort of B/AA and Latinx 108 transgender and gender nonconforming/non-binary youth (TGMY), called the TRUTH Cohort. Both HYM and TRUTH participants were 16 to 24 years of age at the time of recruitment. The overarching aim was to conduct longitudinal research focused on these youths’ engagement in the HIV prevention and care continua in an effort to prevent new HIV infections, reduce transmission, and reduce HIV/AIDS-related disparities. Mixed methods research is conducted using qualitative interviews, a self- report survey, drug screening, and testing for sexually transmitted infections (STIs) and HIV. Biospecimens (plasma, buffy coat, rectal swabs) are also collected and banked. Analyses performed to date provide clear evidence that participants in both cohorts are at high risk for HIV, drug use, and mental health/psychiatric conditions. Intersectional stigma—i.e., experiences of stigma stemming from multiple, intersecting identities1- 5—also appears to discourage AA/B and Latinx YMSM and TGMY from engaging in care and perhaps may impact their developmental arcs of risk, transmission, and health. Building on this work, we are proposing to longitudinally: i) examine B/L-YMSM’s engagement in the HIV prevention and care continua, as well as their developmental transitions and trajectories in drug use, STI/HIV infection, health, and psychiatric/mental health comorbidities (Aim 1); ii) examine TGMY’s engagement in the HIV prevention and care continua and identify shared and unique transitions and trajectories with respect to TGMY’s use of drugs, infections with STI/HIV, health and psychiatric/mental health comorbidities (Aim 2); and iii) serve as a local and national resource for collaborations and dissemination. We will actively participate in and contribute to the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO), the Coordinating Center for NIDA’s U01 cohorts. We will also partner with key stakeholders (e.g., community organizations, policy makers) and collaborate with trainees, early career faculty and investigators across the translational spectrum (Aim 3).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	8	4/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $2,879,967 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	9	6/23/2023	NON-COMPETING CONTINUATION	$2,879,967
														Subtotal = $2,879,967

Issue Date FY: 2022 ( Subtotal = $2,847,406 )
2022	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	8	7/15/2022	NON-COMPETING CONTINUATION	$2,847,406
														Subtotal = $2,847,406

Issue Date FY: 2021 ( Subtotal = $2,814,849 )
2021	2021	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	003	7	6/10/2021	NON-COMPETING CONTINUATION	$2,814,849
2021	2021	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	004	7	7/21/2021	NON-COMPETING CONTINUATION	$0
2021	2020	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	002	6	11/19/2020	COMPETING CONTINUATION	$0
2021	2020	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	6	11/13/2020	COMPETING CONTINUATION	$573,325
2021	2019	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	5	11/13/2020	NON-COMPETING CONTINUATION	-$573,325
														Subtotal = $2,814,849

Issue Date FY: 2020 ( Subtotal = $2,898,488 )
2020	2020	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	6	6/23/2020	COMPETING CONTINUATION	$2,898,488
														Subtotal = $2,898,488

Issue Date FY: 2019 ( Subtotal = $1,860,016 )
2019	2019	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	5	7/15/2019	NON-COMPETING CONTINUATION	$1,860,016
														Subtotal = $1,860,016

Issue Date FY: 2018 ( Subtotal = $1,858,944 )
2018	2018	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	4	7/23/2018	NON-COMPETING CONTINUATION	$1,858,944
														Subtotal = $1,858,944

Issue Date FY: 2017 ( Subtotal = $1,969,363 )
2017	2017	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	002	3	8/11/2017	SUPPLEMENT FOR EXPANSION	-$66,498
2017	2017	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	3	6/27/2017	NON-COMPETING CONTINUATION	$1,869,363
2017	2017	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	3	7/11/2017	SUPPLEMENT FOR EXPANSION	$166,498
														Subtotal = $1,969,363

Issue Date FY: 2016 ( Subtotal = $1,918,824 )
2016	2016	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	2	7/18/2016	NON-COMPETING CONTINUATION	$1,871,185
2016	2015	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	001	1	7/19/2016	NEW	$47,639
														Subtotal = $1,918,824

Issue Date FY: 2015 ( Subtotal = $1,307,179 )
2015	2015	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Drug Abuse and Addiction Research Programs	000	1	8/13/2015	NEW	$1,307,179
														Subtotal = $1,307,179

Grand Total All Awards = $20,355,036

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Using Longitudinal Research to Engage African American and Latinx Sexual- and Gender-Minority Youth in the HIV Prevention and Care Continua and Reduce HIV/AIDS-Related Disparities

Award Number: U01DA036926

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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