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AIDS Linked to the IntraVenous Experience (ALIVE)

Award Number: U01DA036297
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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AIDS Linked to the IntraVenous Experience (ALIVE) - ABSTRACT In this competing renewal, we propose to continue a 30-year cohort of people who inject drugs (PWID). Since 1988, the AIDS Linked to the IntraVenous Experience (ALIVE) study has followed >5200 PWID in a community-based cohort in Baltimore, MD, providing critical insight into the natural and treated course of HIV among urban predominantly minority, disadvantaged PWID. Our team has been highly productive (107 publications in past cycle) and will continue cutting-edge investigations into high HIV/AIDS priority research questions, while serving as a foundation for an array of HIV-related epidemiological and pathogenesis studies. The opioid crisis across the US continues and has not abated in Baltimore. Baltimore has one of the highest US overdose rates and is experiencing demographic and behavioral transitions in the population most affected by opioid use -- from one that is primarily male, older and minority -- to one that affects more women, younger and white individuals. At the same time, there has also been a shift in the expression of HIV infection among PWID. Much of the population of PWID that the ALIVE study has traditionally followed is aging into the decade of life where HIV and its treatment are complicated by the onset of other chronic age-associated health conditions; in 2016, 40% of our cohort had >2 non-communicable diseases (NCD). At the same time <50% of our HIV-positive participants currently have suppressed HIV viral load highlighting a need for a more holistic approach to HIV care one that more broadly incorporates NCDs. Our proposed continuation will address the spectrum of the intersecting HIV and opioid epidemics with an eye towards understanding the impact of opioid use and HIV across the PWID life course. Our Specific Aims are: 1) To monitor temporal trends in the opioid epidemic comparing HIV infected and uninfected PWID across the lifespan, including characterization of shifting drug profiles and context over time and their impact on the incidence of fatal and non-fatal overdose, HIV and HCV infection and mortality. 2) To evaluate the dynamic associations between HIV care continuum outcomes and prevalence and control of NCDs (e.g., diabetes, hypertension, hyperlipidemia, chronic obstructive pulmonary disease [COPD]) and their joint impact on morbidity, mortality and quality of life; and 3) To continue to provide a platform for independently-funded investigations of HIV and drug use. To achieve these aims, we will 1) continue follow-up of HIV positive and negative PWID (~1500); 2) open recruitment once; and 3) evolve our data collection methods to include novel field-based, mHealth and drug testing assessments. The ALIVE cohort is unique in that it comprises a community-based PWID population of both genders with significant representation of African-Americans who are both in and out of medical care; these populations have been underrepresented in HIV and drug use research. Given the scientific rigor of the proposed methods, existing infrastructure, experienced investigators and multiple NIH-funded ancillary studies, we anticipate continued success and substantial scientific impact in the future. !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	002	11	3/10/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	004	11	5/2/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	11	2/14/2025	EXTENSION WITH OR WITHOUT FUNDS	$1,264,234
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	003	11	3/31/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	10	2/14/2025	NON-COMPETING CONTINUATION	-$1,264,234
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,436,595 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	11	12/15/2023	EXTENSION WITH OR WITHOUT FUNDS	$2,436,595
2024	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	10	10/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,436,595

Issue Date FY: 2023 ( Subtotal = $2,437,098 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	002	10	1/11/2023	NON-COMPETING CONTINUATION	$243,709
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	10	12/14/2022	NON-COMPETING CONTINUATION	$2,193,389
2023	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	9	12/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,437,098

Issue Date FY: 2022 ( Subtotal = $2,481,745 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	9	3/18/2022	NON-COMPETING CONTINUATION	$248,087
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	9	12/2/2021	NON-COMPETING CONTINUATION	$2,232,776
2022	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	002	5	9/26/2022	NON-COMPETING CONTINUATION	$882
														Subtotal = $2,481,745

Issue Date FY: 2021 ( Subtotal = $2,493,073 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	8	2/19/2021	NON-COMPETING CONTINUATION	$249,309
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	8	12/11/2020	NON-COMPETING CONTINUATION	$2,243,764
														Subtotal = $2,493,073

Issue Date FY: 2020 ( Subtotal = $2,521,954 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	002	7	4/29/2020	NON-COMPETING CONTINUATION	$0
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	7	2/10/2020	NON-COMPETING CONTINUATION	$252,197
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	7	12/6/2019	NON-COMPETING CONTINUATION	$2,269,757
														Subtotal = $2,521,954

Issue Date FY: 2019 ( Subtotal = $2,554,475 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	6	5/9/2019	COMPETING CONTINUATION	$300,527
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	6	4/2/2019	COMPETING CONTINUATION	$2,253,948
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	003	6	7/12/2019	COMPETING CONTINUATION	$918,643
2019	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	002	5	7/12/2019	NON-COMPETING CONTINUATION	-$918,643
														Subtotal = $2,554,475

Issue Date FY: 2018 ( Subtotal = $1,798,764 )
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	5	4/26/2018	NON-COMPETING CONTINUATION	$179,875
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	5	12/28/2017	NON-COMPETING CONTINUATION	$1,618,889
														Subtotal = $1,798,764

Issue Date FY: 2017 ( Subtotal = $1,791,772 )
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	4	11/29/2016	NON-COMPETING CONTINUATION	$1,612,595
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	4	5/22/2017	NON-COMPETING CONTINUATION	$179,177
														Subtotal = $1,791,772

Issue Date FY: 2016 ( Subtotal = $1,772,479 )
2016	2016	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	3	11/19/2015	NON-COMPETING CONTINUATION	$1,611,346
2016	2016	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	3	3/8/2016	NON-COMPETING CONTINUATION	$161,133
														Subtotal = $1,772,479

Issue Date FY: 2015 ( Subtotal = $1,772,707 )
2015	2015	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	2	11/21/2014	NON-COMPETING CONTINUATION	$1,619,733
2015	2015	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	001	2	2/10/2015	NON-COMPETING CONTINUATION	$152,974
														Subtotal = $1,772,707

Issue Date FY: 2014 ( Subtotal = $1,797,375 )
2014	2014	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	1	12/19/2013	NEW	$1,797,375
														Subtotal = $1,797,375

Grand Total All Awards = $23,858,037

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AIDS Linked to the IntraVenous Experience (ALIVE)

Award Number: U01DA036297

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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