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Multi-level modeling to inform interventions for control of multidrug-resistant organisms within healthcare networks

Award Number: U01CK000536
ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Multidrug-resistant organisms (MDROs), particularly carbapenem-resistant organisms (CROs), are a major cause of healthcare-associated infections (HAIs). Though studies have found multiple interventions addressing MDRO colonization and transmission to be effective at reducing HAIs, implementation has lagged due to questions regarding the most efficacious combination of interventions. As healthcare facilities (e.g., hospitals, long-term care facilities, or outpatient surgical centers and clinics) are part of an interconnected healthcare network, evaluation of an intervention’s impact on transmission and infection must consider the dynamics across the healthcare system. To address remaining knowledge gaps regarding the most effective combinations of intervention strategies, we will build a multi-level model that spans from individual patients to regionally interconnected healthcare facilities. The resulting framework will provide hospital administrators and infection control experts with tools for quantifying individual patient risk factors for colonization and infection and for comparing the potential effectiveness of interventions to control HAIs. The aims of the project are: (1) to develop models to estimate the underlying prevalence and incidence of CROs and predict which patients are at highest risk for colonization and infection with CROs using clinical samples collected during the normal course of care; (2) to utilize hospital-level models to quantify the combinatorial relationship between, and marginal impact of, additional interventions to reduce HAIs; and (3) to build a regional model of a healthcare system to examine the effectiveness of interventions across institutions. Models will start with the patient at the center, utilizing the rich covariate data stored in electronic medical records to develop prediction models based on advanced machine learning. These prediction models will be translatable tools that can be directly incorporated into clinical care to assist clinicians in preventing HAIs. In addition, they will form the foundation of hospital-level models that will allow for detailed examinations of the effectiveness of different combinations of interventions. Hospital-level models will then be embedded in a network of healthcare facilities that accounts for the differing incentives faced by geographically dispersed facilities with variable demographic populations. These models will directly inform CDC guidelines about MDRO prevention and aid clinicians in reducing the risk of HAIs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$55,574 )
2021	2019	CENTER FOR DISEASE DYNAMICS, ECONOMICS & POLICY, INC., THE	962 WAYNE AVE STE 530	SILVER SPRING	MD	20910	MONTGOMERY	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	03	3	4/8/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$55,574
2021	2018	CENTER FOR DISEASE DYNAMICS, ECONOMICS & POLICY, INC., THE	962 WAYNE AVE STE 530	SILVER SPRING	MD	20910	MONTGOMERY	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	03	3	4/8/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2017	CENTER FOR DISEASE DYNAMICS, ECONOMICS & POLICY, INC., THE	962 WAYNE AVE STE 530	SILVER SPRING	MD	20910	MONTGOMERY	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	03	3	4/8/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$55,574

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	Center For Disease Dynamics, Economics & Policy, Inc. (The)	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	02	3	4/15/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2019	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	3	11/15/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2017	CENTER FOR DISEASE DYNAMICS, ECONOMICS & POLICY, INC., THE	962 WAYNE AVE STE 530	SILVER SPRING	MD	20910	MONTGOMERY	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	02	1	8/2/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $646,905 )
2019	2019	Center for Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	00	3	6/21/2019	NON-COMPETING CONTINUATION	$646,905
2019	2018	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	2	1/8/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2018	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	02	2	3/15/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	2	1/8/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	02	2	3/15/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2019	2017	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	1	1/8/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $646,905

Issue Date FY: 2018 ( Subtotal = $649,871 )
2018	2018	Center For Disease Dynamics, Economics & Policy	1400 Eye St NW Ste 500	Washington	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	00	2	6/20/2018	NON-COMPETING CONTINUATION	$649,871
														Subtotal = $649,871

Issue Date FY: 2017 ( Subtotal = $649,361 )
2017	2017	CENTER FOR DISEASE DYNAMICS, ECONOMICS & POLICY	1400 EYE ST NW STE 500	WASHINGTON	DC	20005	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	1	7/28/2017	NEW	$649,361
														Subtotal = $649,361

Grand Total All Awards = $1,890,563

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Multi-level modeling to inform interventions for control of multidrug-resistant organisms within healthcare networks

Award Number: U01CK000536

ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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