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Research Study to Assess the Risk of Blood Borne Transmission of Classic Forms of Creutzfeldt-Jakob Disease

Award Number: U01CK000360
ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): Creutzfeldt-Jakob disease (CJD) is a rare fatal neurodegenerative disorder caused by abnormal prion agents. Transmissibility of the classic forms of CJD by blood transfusion is currently unknown. The proposed project will continue the only active, nationwide look-back study on recipients of blood products from donors subsequently diagnosed with classic CJD. This study began in 1995, and has been working for the past 20 years on the key objective of carefully and systematically assessing the risk of blood borne transmission of this disease in the United States. The major components of the study include collaboration with multiple sources to identify blood donors diagnosed with classic CJD in the United States; working with blood centers to trace the blood components from donors diagnosed with classic CJD to final disposition; collecting vital status and cause of death information (if applicable) on the recipients of blood components; utilizing the data from the study to continually monitor and assess the risk of blood-borne transmission of CJD; and disseminating results of the study to relevant stakeholders. To date, the study has enrolled 54 blood donors who died of classic CJD and 666 recipients of their blood. Through 2013, 125 of these recipients were presumed to be still alive, 520 were deceased and 21 were lost to follow-up. Post transfusion, these three groups had survived a total of 2719.5 person-years. A total of 187 recipients survived five years or longer post transfusion and 86 of them had received blood donated 60 or fewer months before the onset of CJD in the donor. No recipients with CJD have been identified. The current results of this large, ongoing look-back study show no evidence of transfusion transmission of CJD. They reinforce the conclusion that the risk, if any, of transfusion transmission of prion disease by classic CJD donors is significantly lower than the comparable risk of such transmission by vCJD donors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$394 )
2021	2018	American National Red Cross, The	431 18th Street	Washington	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	5	9/29/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$394
2021	2017	American National Red Cross, The	431 18th Street	Washington	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	5	9/29/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2016	American National Red Cross, The	431 18th Street	Washington	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	5	9/29/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2015	American National Red Cross, The	431 18th Street	Washington	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	5	9/29/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2014	American National Red Cross, The	431 18th Street	Washington	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	01	5	9/29/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$394

Issue Date FY: 2018 ( Subtotal = $75,996 )
2018	2018	American National Red Cross, The	431 18th St	Washington	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	00	5	8/15/2018	NON-COMPETING CONTINUATION	$75,996
														Subtotal = $75,996

Issue Date FY: 2017 ( Subtotal = $76,000 )
2017	2017	AMERICAN NATIONAL RED CROSS, THE	431 18TH ST	WASHINGTON	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	001	4	6/23/2017	NON-COMPETING CONTINUATION	$76,000
2017	2016	AMERICAN NATIONAL RED CROSS	2025 E ST NW	WASHINGTON	DC	20006	DISTRICT OF COLUMBIA	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	3	2/2/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $76,000

Issue Date FY: 2016 ( Subtotal = $76,000 )
2016	2016	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	002	3	9/26/2016	NON-COMPETING CONTINUATION	$76,000
2016	2016	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	3	8/19/2016	NON-COMPETING CONTINUATION	$76,000
2016	2016	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	001	3	9/12/2016	NON-COMPETING CONTINUATION	-$76,000
														Subtotal = $76,000

Issue Date FY: 2015 ( Subtotal = $76,000 )
2015	2015	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	001	2	8/19/2015	NON-COMPETING CONTINUATION	$76,000
2015	2015	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	002	2	8/22/2015	NON-COMPETING CONTINUATION	$0
2015	2014	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	1	11/6/2014	COMPETING CONTINUATION	$0
														Subtotal = $76,000

Issue Date FY: 2014 ( Subtotal = $75,893 )
2014	2014	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	002	1	11/6/2014	COMPETING CONTINUATION	$0
2014	2014	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	000	1	7/30/2014	COMPETING CONTINUATION	$75,893
2014	2014	AMERICAN NATIONAL RED CROSS HEADQUARTERS	600 A FOREST POINT CIRCLE	CHARLOTTE	NC	28273	MECKLENBURG	USA	Prevention of Disease, Disability, and Death by Infectious Diseases	001	1	7/31/2014	COMPETING CONTINUATION	$0
														Subtotal = $75,893

Grand Total All Awards = $379,495

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Research Study to Assess the Risk of Blood Borne Transmission of Classic Forms of Creutzfeldt-Jakob Disease

Award Number: U01CK000360

ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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