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Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi

Award Number: U01CA294756
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi - Project Summary/Abstract Human papillomavirus (HPV) vaccination is a critical cancer control intervention, particularly in resource- constrained health systems with limited access to screening and treatment services. Malawi, like many African countries, has introduced a national HPV vaccine program targeting preadolescent girls – but coverage remains very low. Clinician recommendation of HPV vaccination is a highly effective evidence-based intervention for increasing uptake of the vaccine, but there is little information on how to encourage clinicians in low- and middle- income countries to deliver this recommendation. The Kupewa project (“prevent” in Chichewa) aims to (A) identify the optimal implementation strategies for increasing clinician recommendation of HPV vaccination for girls and young women aged 9-24 who are living with HIV in Malawi; (B) refine this set of optimized strategies by including information about the strategies’ implementability; and (C) ultimately identify the set of strategies that are effective, implementable, and show sustained effects 18 months after the intervention ends. The study is informed by the Theoretical Domains Framework and the World Health Organization’s Behavioural and Social Drivers (BeSD) of vaccination framework. To our knowledge, this would be among the first applications of intervention optimization alongside implementation science, and among the first to be conducted in a low-income country. The project will leverage a robust research partnership between institutions and highly-qualified investigators in Malawi and the U.S., with engagement of partners from the Malawi Ministry of Health in all phases, from conceptualization to study execution and results interpretation and dissemination. Clinician-facing implementation strategies to promote vaccination recommendation in low- and middle-income countries are understudied but urgently needed to accelerate HPV vaccination programs globally. This study will provide much-needed insight into ways to promote clinician recommendation of HPV vaccination to the highest- risk girls and young women in the country with the second-highest burden of cervical cancer globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Cancer Cause and Prevention Research	000	1	11/21/2024	NEW	$0
2025	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Cancer Cause and Prevention Research	001	1	4/16/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $612,499 )
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Cancer Cause and Prevention Research	000	1	8/14/2024	NEW	$612,499
														Subtotal = $612,499

Grand Total All Awards = $612,499

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Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi

Award Number: U01CA294756

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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