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Advancing Prevention Research In Cancer through Ontology Tools (The APRICOT project) Project Narrative

Award Number: U01CA291884
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Advancing Prevention Research In Cancer through Ontology Tools (The APRICOT project) Project Narrative - Abstract Progress in behavioral research in cancer prevention is hampered by imprecision and heterogeneity in research and how it is reported. Ontologies provide a way of addressing this barrier by promoting clarity, coherence and interoperability across studies and data sets. We have developed the Behavior Change Intervention Ontology (BCIO) using ‘Fair Guiding Principles’ that has been recognized as the most semantically rich ontology in its domain, and its user-informed method of development as particularly innovative. However, it does not cover all the key classes and relations needed. In addition, our tools for using the ontology are at an early stage of development. The APRICOT team, propose three key areas of activity: (i) Extend the BCIO to cover additional details of two key behaviors (tobacco use and physical activity), methodological features of studies evaluating behavior change interventions (including links between measures and constructs), and causal links between intervention components and mechanisms of action (processes of change), (ii) Integrate the BCIO and ontologies covering the connections between physical and health and health-related behaviors to inform personalization of clinical and population health recommendations), (iii) Develop tools and resources to build engagement with, and adoption of, the BCIO for, e.g., writing study reports and protocols, and synthesizing evidence for theory and intervention development. To achieve this, we will foster and work with a cross-domain Community of Practice (CoP). Throughout the project we will follow FAIR Guiding Principles and established methodologies based on science, working with our CoP as stakeholders to ensure that the ontology and its tools and resources are developed and implemented in a way that promotes widespread adoption and meets the varied and evolving needs of users. We will work to ensure that the BCIO, its mapping to other ontologies and its tools and resources can be sustained and enhanced beyond the life of the project. We will use established methodologies to extend the BCIO and integrate (i.e., re-use classes) with, and where this is not feasible to map (i.e., cross-reference) to, other ontologies. These include top-down (expert- and user-led) and bottom-up (searching reports and data) approaches to identifying priority classes and relations to add to the ontology and iterating the process of editing labels, definitions and other meta-data (including cross-references) in close collaboration with our CoP. To upgrade and extend our tools and resources we will continue to adopt our established methodologies of ethical and efficient design used in generating the current version, again working closely with our CoP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $477,460 )
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Cause and Prevention Research	000	2	9/5/2025	NON-COMPETING CONTINUATION	$477,460
														Subtotal = $477,460

Issue Date FY: 2024 ( Subtotal = $501,479 )
2024	2024	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Cause and Prevention Research	000	1	8/26/2024	NEW	$501,479
														Subtotal = $501,479

Grand Total All Awards = $978,939

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Advancing Prevention Research In Cancer through Ontology Tools (The APRICOT project) Project Narrative

Award Number: U01CA291884

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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