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A national Asian American cohort for assessing multi-level determinants in cancer etiology: the ASPIRE Cohort

Award Number: U01CA290831
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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A national Asian American cohort for assessing multi-level determinants in cancer etiology: the ASPIRE Cohort - Abstract Large-scale prospective epidemiologic cohorts have been instrumental for discoveries of novel cancer risk factors. Moreover, traditional studies of populations with unique and dynamic exposure profiles have provided significant insights into cancer etiology. As we increasingly appreciate the multi-factorial contributions to cancer risk, we propose a paradigm shift in studies of cancer risk to include the examination of multilevel drivers of health, and the development of a methodologic approach to study the interactive effects of these drivers. Focusing on the Asian American population, a heterogeneous group with varying and rapidly changing exposure profiles, will provide invaluable insights on cancer risk factors and their pathways to cancer incidence. This will generate knowledge benefitting the health for all U.S. populations. We propose to establish the national ASPIRE– ASian American ProspectIve REsearch cohort, beginning with 20,000 adults ages 40-75 via focused community-engaged recruitment in six regions that comprise more than a third of the Asian American population (California (Bay Area, Los Angeles, Orange County, Sacramento), New York Metro/North Jersey, and Greater Philadelphia Metro/South Jersey), in addition to national outreach to other U.S. regions. This population-based cohort will include: 1) multiple Asian American communities; 2) collection of data on health behavior exposures across the life course; 3) detailed information on area-level factors; 4) a precision adaptive design to develop best practices for community-engaged research; and 5) methodologic research on analytic approaches to assess small populations and multilevel interactions. This cohort is supported by a national network of researchers and community partners with expertise in Asian American health and well-being. We will use transparent and bi-directional processes among scientific and community collaborators to inform research priorities, data collection and sharing, and dissemination of timely and actionable study results. The ASPIRE Cohort will thus be suitable to identify novel multilevel contributors to cancer risk. This first phase will address multilevel drivers of health and their impacts on multiple pathways to cancer initiation that considers: 1) healthcare access and cancer screening, 2) cancer-relevant health behaviors, and 3) stress exposures. The ultimate vision of ASPIRE is to serve as a rich, contemporary epidemiologic resource to advance our understanding of cancer etiology that will benefit all populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,507,375 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Cause and Prevention Research	001	3	6/25/2026	NON-COMPETING CONTINUATION	$2,507,375
2026	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Cause and Prevention Research	000	2	12/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,507,375

Issue Date FY: 2025 ( Subtotal = $2,506,882 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Cause and Prevention Research	000	2	7/17/2025	NON-COMPETING CONTINUATION	$2,506,882
														Subtotal = $2,506,882

Issue Date FY: 2024 ( Subtotal = $2,514,759 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Cause and Prevention Research	000	1	7/8/2024	NEW	$2,514,759
														Subtotal = $2,514,759

Grand Total All Awards = $7,529,016

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A national Asian American cohort for assessing multi-level determinants in cancer etiology: the ASPIRE Cohort

Award Number: U01CA290831

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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