Monday, September 15, 2025 9/15/2025

A Multi-level Approach to Connecting Individuals to Cancer Clinical Research

Award Number: U01CA274970
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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A Multi-level Approach to Connecting Individuals to Cancer Clinical Research - Increasing patient participation in cancer clinical trials (CCTs) is vital to the advancement of oncology across the continuum of care. Low trust in clinical research and recruitment approaches that fail to address multilevel barriers to CCT participation are key reasons for poor study recruitment. Community health educators (CHEs) improve trust in research among many communities; yet relying exclusively on CHE availability can limit intervention reach. Virtual CHEs (vCHEs) improve scalability by extending CHE capabilities and capitalizing on remote recruitment techniques. The purpose of the current project is to increase the referral of patients to NCI-supported CCTs via a tailored, multi-level intervention. The ALEX Research Referral Portal utilizes adaptive virtual human technology that provides users with tailored CCT information. Through AI-enabled technology, human CHEs can become vCHEs to reach patients through digital outreach. Clinicians can utilize the portal to refer patients to CCTs; however, patients, families, and community members can also use the portal to easily navigate key information and make self-referrals. The ability to streamline research information from https://clinicaltrials.gov/ to patients, and then CCT referral from patient to study coordinators, is expected to improve referral to CCTs. The ALEX Research Portal will be developed with unique a multi-cancer center collaborative opportunity to provide access to patients in Florida and the nation, and in coordination with cancer centers conducting CCTs associated with national networks (ETCTN, NCTN, NCORP). Guided by the Interactive Systems Framework, this project will be conducted in three phases: establish a baseline of referrals and accrual of patients to CCTs across multiple Florida Cancer Centers (Phase 1), adapt and pilot the ALEX Research Referral Portal using a randomized controlled clinical trial (Phase 2), and scale the intervention by dissemination through national networks (Phase 3). The proposed study will result in an empirically-tested intervention that can easily be adapted and disseminated across the state and nation to overcome multi-level challenges associated with recruiting participants to CCTs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $470,401 )
2025	2025	MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION)	4500 SAN PABLO RD S	JACKSONVILLE	FL	32224	DUVAL	USA	Cancer Cause and Prevention Research	001	5	8/18/2025	NON-COMPETING CONTINUATION	$470,401
2025	2024	MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION)	4500 SAN PABLO RD S	JACKSONVILLE	FL	32224	DUVAL	USA	Cancer Cause and Prevention Research	000	4	4/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $470,401

Issue Date FY: 2024 ( Subtotal = $656,994 )
2024	2024	MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION)	4500 SAN PABLO RD S	JACKSONVILLE	FL	32224	DUVAL	USA	Cancer Cause and Prevention Research	004	4	9/5/2024	NON-COMPETING CONTINUATION	$656,994
2024	2023	MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION)	4500 SAN PABLO RD S	JACKSONVILLE	FL	32224	DUVAL	USA	Cancer Cause and Prevention Research	003	3	8/15/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$361,328
2024	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	2	1/31/2024	NON-COMPETING CONTINUATION	-$682,863
2024	2023	MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION)	4500 SAN PABLO RD S	JACKSONVILLE	FL	32224	DUVAL	USA	Cancer Cause and Prevention Research	001	3	1/31/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$682,863
2024	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	002	1	8/15/2024	NEW	-$361,328
														Subtotal = $656,994

Issue Date FY: 2023 ( Subtotal = $682,863 )
2023	2023	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	2	8/22/2023	NON-COMPETING CONTINUATION	$682,863
														Subtotal = $682,863

Issue Date FY: 2022 ( Subtotal = $704,063 )
2022	2022	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Cancer Cause and Prevention Research	000	1	9/9/2022	NEW	$704,063
														Subtotal = $704,063

Grand Total All Awards = $2,514,321

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A Multi-level Approach to Connecting Individuals to Cancer Clinical Research

Award Number: U01CA274970

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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