Monday, October 27, 2025 10/27/2025

ARCHERY: Artificial Intelligence based Radiotherapy treatment planning for Cervical and Head and Neck cancer

Award Number: U01CA269143
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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ARCHERY: Artificial Intelligence based Radiotherapy treatment planning for Cervical and Head and Neck cancer - PROJECT SUMMARY 50% of cancer patients require radiotherapy during their disease course, however, only 10-40% of patients in low and middle-income countries (LMICs), have access to it. A shortfall in the specialised workforce to deliver radiotherapy has been identified as the most significant barrier to expanding radiotherapy capacity. The current radiotherapy workflow is inefficient requiring several labor intensive processes and takes weeks to months to deliver in LMICs. The growing demand for cancer treatment means that the ratio of incidence to mortality will continue to worsen without a scalable solution. Artificial intelligence (AI) based software has been developed to automate two components of the radiotherapy planning pathway 1. Delineation of anatomical areas that are at risk of tumour spread and at risk of radiation damage. 2. Definition of the position, size and shape of the radiation beams. Proposed advantages include improved treatment accuracy, as well as a reduction in the time (from weeks to less than a day) and human resources needed to deliver radiotherapy. We propose a non-randomised prospective study to evaluate the quality and economic impact of AI based automated radiotherapy treatment for cervical cancer and head and neck cancers, which are endemic in LMICs, and for which radiotherapy is the primary curative treatment modality. The sample size of 706 patients (353 for each cancer type) has been calculated based on an estimated 95% treatment plan acceptability rate. Time and cost savings will be analysed as secondary outcome measures to establish the cost and resource impact of automation using the time-driven activity-based costing model. The 48-month study will take place in six public sector cancer hospitals in India (n=2), Jordan (n=1), Malaysia (n=1), and South Africa (n=2) to ensure we include a broad range of patients and the representativeness of the findings will support implementation of the software in LMICs. If the study objectives are met, the AI based software will be offered as a not-for-profit web service to public sector state hospitals in LMICs to support expansion of high quality radiotherapy capacity, improving access, and affordability of this key modality of cancer cure and control.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $451,097 )
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	004	3	9/16/2025	SUPPLEMENT FOR EXPANSION	$40,177
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	009	3	9/18/2025	SUPPLEMENT FOR EXPANSION	$42,519
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	000	3	9/4/2025	NON-COMPETING CONTINUATION	$257,902
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	005	3	9/17/2025	SUPPLEMENT FOR EXPANSION	$24,653
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	001	3	9/12/2025	NON-COMPETING CONTINUATION	-$42,454
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	008	3	9/18/2025	SUPPLEMENT FOR EXPANSION	$48,750
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	003	3	9/15/2025	SUPPLEMENT FOR EXPANSION	$6,111
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	007	3	9/18/2025	SUPPLEMENT FOR EXPANSION	$16,051
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	006	3	9/18/2025	SUPPLEMENT FOR EXPANSION	$25,800
2025	2025	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	002	3	9/12/2025	SUPPLEMENT FOR EXPANSION	$31,588
														Subtotal = $451,097

Issue Date FY: 2024 ( Subtotal = $430,737 )
2024	2024	UNIVERSITY COLLEGE LONDON	GOWER STREET	LONDON				GBR	Cancer Treatment Research	001	2	8/23/2024	NON-COMPETING CONTINUATION	$430,737
2024	2022	REDACTED DUE TO PII		LONDON				GBR	Cancer Treatment Research	000	1	10/19/2023	NEW	$0
														Subtotal = $430,737

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	REDACTED DUE TO PII		LONDON				GBR	Cancer Treatment Research	000	1	2/17/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $457,388 )
2022	2022	REDACTED DUE TO PII		LONDON				GBR	Cancer Treatment Research	000	1	8/25/2022	NEW	$457,388
														Subtotal = $457,388

Grand Total All Awards = $1,339,222

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ARCHERY: Artificial Intelligence based Radiotherapy treatment planning for Cervical and Head and Neck cancer

Award Number: U01CA269143

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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