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Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions

Award Number: U01CA253858
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/03/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions - Project Summary Abstract Lung cancer remains the leading cause of cancer related mortality in the US and globally— responsible for ~1.8 million deaths annually. As collaborative investigators of the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Working Group (LWG), we have contributed to the development of US national strategies for reducing the lung cancer burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall mortality, and by evaluating the population benefits and harms of lung cancer screening in the US. Due to ongoing reductions in smoking in the US, lung cancer mortality is projected to continue declining. However, lung cancer is still expected to result in over 4 million deaths over the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and treatment interventions will be critical to further reduce the lung cancer burden in the US. Moreover, as new tobacco products, such as e-cigarettes (e-cigs), become more popular, there are concerns that the gains achieved in the fight against smoking could reverse. We propose to continue our work and extend our models to assess the impact of 1) future tobacco control interventions in the ever-changing tobacco market landscape, 2) improvements in lung cancer screening and other emerging early detection strategies, 3) innovations in lung cancer treatment, and importantly, 4) their synergistic interactions on lung cancer rates and overall mortality in the US and globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Cause and Prevention Research	001	5	9/13/2024	NON-COMPETING CONTINUATION	$0
2024	2023	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Cause and Prevention Research	000	5	10/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,523,795 )
2023	2023	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Cause and Prevention Research	007	5	9/11/2023	NON-COMPETING CONTINUATION	$1,244,617
2023	2023	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Cause and Prevention Research	008	5	9/12/2023	NON-COMPETING CONTINUATION	$279,178
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	3	4/27/2023	NON-COMPETING CONTINUATION	-$1,600,160
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	004	3	9/8/2023	NON-COMPETING CONTINUATION	-$101,571
2023	2022	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Cause and Prevention Research	006	4	9/8/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,123,646
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	005	3	9/8/2023	SUPPLEMENT FOR EXPANSION	-$42,585
2023	2022	PROVINCIAL HEALTH SERVICES AUTHORITY	600 10TH AVE W	VANCOUVER	BC			CAN	Cancer Cause and Prevention Research	001	4	4/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,600,160
2023	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	002	2	9/8/2023	NON-COMPETING CONTINUATION	-$939,365
2023	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	003	2	9/8/2023	SUPPLEMENT FOR EXPANSION	-$40,125
														Subtotal = $1,523,795

Issue Date FY: 2022 ( Subtotal = $1,744,316 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	001	3	9/7/2022	SUPPLEMENT FOR EXPANSION	$42,585
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	3	8/31/2022	NON-COMPETING CONTINUATION	$1,701,731
														Subtotal = $1,744,316

Issue Date FY: 2021 ( Subtotal = $1,806,423 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	2	8/13/2021	NON-COMPETING CONTINUATION	$1,732,423
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	001	2	9/13/2021	SUPPLEMENT FOR EXPANSION	$74,000
														Subtotal = $1,806,423

Issue Date FY: 2020 ( Subtotal = $1,802,154 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Cancer Cause and Prevention Research	000	1	9/8/2020	NEW	$1,802,154
														Subtotal = $1,802,154

Grand Total All Awards = $6,876,688

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Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions

Award Number: U01CA253858

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/03/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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