Sunday, November 9, 2025 11/9/2025

A data analytics framework for mining the dark kinome

Award Number: U01CA239106
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2023

Group Awards By:

View Award Description

A data analytics framework for mining the dark kinome - Project Summary The overall goal of this proposal is to generate and experimentally test models of understudied “dark” kinase evolution and function, and to develop a data-analytics framework for hypothesis generation and testing on the dark kinome. Our working hypothesis is that integrative mining of available sequence, structure, and functional data on the entire kinome from diverse organisms (both well-studied and dark kinases) will provide important context for defining sequence and structural features associated with dark kinase functions. As a preliminary test of our hypothesis, we have integrated and conceptualized diverse forms of data related to protein kinase structure, function, and evolution in the form of the Protein Kinase Ontology (ProKinO), and successfully demonstrated the application of an ontological framework in identifying key knowledge gaps in the human kinome and in discovering key residues/motifs associated with protein kinase regulation. We propose to build on these successful studies to accomplish the following two aims. Aim1 will develop a novel comparative kinomics framework in which natural and disease variants in dark kinases will be correlated and visualized in the context of PTMs and protein-protein interactions to investigate the relationships connecting sequence, structure, function and regulation. Models of functional specialization will be experimentally tested in selected dark and pseudokinases using biochemical and cell-based assays and made publically available in human and machine-readable format, adhering to Findable, Accessible, Interoperable and Reusable (FAIR) data rules. Aim2 will build a unique framework for complex aggregate queries on semantically linked protein kinase data from disparate sources and formats using graphical, easy to use interfaces. Researchers will interact with the framework and formulate queries based on a familiar and intuitive view of the data. A knowledge map-based interactive query interface will be developed using which researchers can interact with ProKinO using semantics they use and understand. ProKinO will be formally linked with Pharos, the Drug Target Ontology (DTO) and the Protein Ontology (PRO) to expand community outreach and user base. The proposed studies are expected to provide a unified data analytics framework for knowledge discovery and hypothesis generation on the dark kinome and enhance the ability of the Illuminating the Druggable Genome (IDG) consortium to make accurate predictions about the physiological roles of dark kinases. The proposed integration of ProKinO with DTO and PRO will enhance the application of these ontologies in drug discovery and provide open source software for building data instantiated ontologies for other IDG targets such as ion- channels and GPCRs. These outcomes, in turn, are expected to accelerate the functional characterization of the druggable “dark” proteome and address the IDG initiative of translating genomic data into knowledge for drug discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1 )
2024	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	000	2	11/8/2023	SUPPLEMENT FOR EXPANSION	-$1
														Subtotal = -$1

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	001	2	3/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	002	2	8/3/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	000	2	3/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $450,215 )
2021	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	001	2	3/24/2021	SUPPLEMENT FOR EXPANSION	$450,215
2021	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	000	2	12/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $450,215

Issue Date FY: 2020 ( Subtotal = $438,510 )
2020	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	000	2	4/15/2020	NON-COMPETING CONTINUATION	$438,510
														Subtotal = $438,510

Issue Date FY: 2019 ( Subtotal = $453,659 )
2019	2019	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Trans-NIH Research Support	000	1	4/15/2019	NEW	$453,659
														Subtotal = $453,659

Grand Total All Awards = $1,342,383

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A data analytics framework for mining the dark kinome

Award Number: U01CA239106

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer