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Life Course Cancer Epidemiology Cohort in Women

Award Number: U01CA176726
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2013
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Life Course Cancer Epidemiology Cohort in Women - Project Summary We propose to continue the follow-up of the Nurses' Health Study II (NHSII), a Cancer Epidemiology Cohort of 116,430 women enrolled at ages 25 to 42 years in 1989. The NHSII is a unique cohort in many ways, as the only large cohort of women enrolled before menopause and with over 30 years of repeated measures of exposures. We have information on smoking, weight, medication use, diet, physical activity, environmental GIS-based exposures, and medical diagnoses updated every two to four years. Further, we have collected detailed data on in utero and infant exposures (from participants' mothers), diet during high school, and other unique exposure information. We have nearly complete ascertainment of deaths using the National Death Index and other methods. The active follow-up of the NHSII cohort remains high, with 88% cumulative follow-up. The NHSII biorepository includes plasma, red blood cells, white blood cells, and first morning urine samples from 29,611 women; two thirds of these women contributed timed follicular and luteal premenopausal samples. In 2008 to 2011, 16,510 women provided second blood and urine samples when the majority were postmenopausal. We also have cheek cell DNA from an additional 29,859 women. Adding to these resources, we recently collected fecal and oral samples from nearly 20,000 participants for microbiome analysis. We have collected archival tissue blocks for incident breast, ovarian, colorectal, endometrial cancers, and lymphomas and melanoma, as well as benign breast and colon lesions (approximately 70% of requests have been obtained), and collections for other cancers are ongoing. Breast and ovarian cancer tissues have been utilized for gene expression, and tissue microarrays are used extensively for immunohistochemistry. Pre- diagnostic mammograms have been collected for breast cancer cases and controls. Substantial proportions of the cohort have GWAS and metabolomic data from nested case-control analyses. This cohort has been highly productive; over 400 papers have been published during the last five years, and the rate of publication is increasingly rapidly. With our active resource sharing component, we have participated in 32 consortia as a member of the NCI Cohort Consortium, one of the few cohorts contributing substantial data on premenopausal women and the largest contributor of premenopausal breast cancers. We also have active data sharing collaborations with many individual external investigators. These external collaborations and consortia have resulted in more than 75 cancer publications during the current funding period. In the current proposal, we aim to continue cohort follow-up and maintain these unique resources. We will continue collecting blood and urine samples from women with breast cancer who also provided pre-diagnostic samples, tumor tissue for incident cancers, and pre-diagnostic pre- and postmenopausal mammograms. We propose to conduct a long-term (2-3 year) reproducibility analysis for genetic sequencing of gut microbiome samples. Finally, we will enhance our data management and analytic tools to maximize efficiency and data sharing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	13	1/29/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $6,360,954 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cancer Cause and Prevention Research	001	13	9/19/2025	EXTENSION WITH OR WITHOUT FUNDS	$6,360,954
2025	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cancer Cause and Prevention Research	000	12	9/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,360,954

Issue Date FY: 2024 ( Subtotal = $2,014,300 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	003	12	8/30/2024	NON-COMPETING CONTINUATION	$2,014,300
2024	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	11	8/28/2024	COMPETING CONTINUATION	$68,618
2024	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	11	7/10/2024	COMPETING CONTINUATION	$0
2024	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	10	8/28/2024	NON-COMPETING CONTINUATION	-$68,618
														Subtotal = $2,014,300

Issue Date FY: 2023 ( Subtotal = $2,135,194 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	11	8/28/2023	COMPETING CONTINUATION	$2,135,194
2023	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	10	5/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,135,194

Issue Date FY: 2022 ( Subtotal = $2,361,000 )
2022	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	10	8/24/2022	NON-COMPETING CONTINUATION	$2,361,000
2022	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	9	8/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,361,000

Issue Date FY: 2021 ( Subtotal = $2,409,183 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	9	8/25/2021	NON-COMPETING CONTINUATION	$2,409,183
2021	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	8	3/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,409,183

Issue Date FY: 2020 ( Subtotal = $2,403,177 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	8	8/26/2020	NON-COMPETING CONTINUATION	$2,403,177
2020	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	7	12/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,403,177

Issue Date FY: 2019 ( Subtotal = $2,332,017 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	7	8/23/2019	NON-COMPETING CONTINUATION	$2,332,015
2019	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	6	1/11/2019	COMPETING CONTINUATION	$2
														Subtotal = $2,332,017

Issue Date FY: 2018 ( Subtotal = $2,423,825 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	6	9/18/2018	COMPETING CONTINUATION	$2,423,825
														Subtotal = $2,423,825

Grand Total All Awards = $22,439,650

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Life Course Cancer Epidemiology Cohort in Women

Award Number: U01CA176726

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2013

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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