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Cancer Epidemiology Cohort in Male Health Professionals

Award Number: U01CA167552
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/21/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Cancer Epidemiology Cohort in Male Health Professionals - The goal of this competing renewal application is to support the core infrastructure and follow-up of the Health Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 U.S. male health professionals age 40 to 75 years at baseline in 1986. This cohort is unique in its focus on men’s health and with 35 years follow-up, provides a time frame essential to study modifiable risk factors for cancer incidence with realistic latencies. Information has been regularly updated on diet, physical activity, smoking, weight, medications, and other potentially modifiable determinants of cancer risk. The biorepository is key element of the cohort and includes DNA, red blood cells, plasma, stool, and toenails. Tumor tissue has been obtained from 7,522 incident cancers of the prostate, colon, bladder, kidney, and lung (nonsmokers), and hematologic cancers. Cohort follow-up is consistently 90% at each two-year cycle and mortality follow-up is virtually complete. At present, 21,853 participants are living and at a heightened age of cancer incidence; these will be the most informative cases given extensive exposure data since midlife. In the current grant, 492 papers were published that utilize data and/or biological samples from HPFS; 317 of these specifically examined cancer or precursor outcomes including >100 led by external investigators. To date, 17,091 participants have been diagnosed with cancer and 4,704 cancer deaths have occurred; 7,061 men are currently living with a cancer diagnosis. In the next funding cycle, we propose the following aims: Aim 1. To actively follow-up for cancer incidence and mortality; to update exposures pre- and post-diagnosis of cancer; Aim 2. To collect data on quality of life, treatment, progression, and cannabis use among cancer survivors. Aim 3. To update the food composition and nutrient databases that support the HPFS and external studies; to jointly calibrate dietary questionnaires with the Southern Community Cohort Study (SCCS) to support combined studies. Aim 4. To maintain and expand the HPFS tissue biorepository to collect tissue from prostate, colon, lung, kidney, and bladder cancers; to pilot artificial intelligence approaches to characterize morphologic features of prostate tumors. Aim 5. To maintain other biorepositories including plasma, red blood cells, toenails, and germline DNA. Aim 6. To expand linkage of geocoded addresses of HPFS and SCCS participants to assess longitudinal measures of the built environment and neighborhood SES over three decades. Aim 7. To maintain and augment the statistical infrastructure and data management to support HPFS analyses by internal and external investigators; to develop new software to facilitate latency and competing risk analyses in HPFS and share with external investigators. Aim 8. To facilitate resource sharing and collaborations with external investigators and consortia, including the transfer of HPFS questionnaire datafiles onto a secure cloud environment. With additional follow-up, including after cancer diagnosis, the HPFS remains ideally positioned to make innovative contributions to our goal of reducing cancer burden by identifying primary and secondary prevention strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,405,685 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	13	7/17/2024	NON-COMPETING CONTINUATION	$1,405,685
2024	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	12	5/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,405,685

Issue Date FY: 2023 ( Subtotal = $1,417,851 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	003	12	8/16/2023	NON-COMPETING CONTINUATION	$1,417,851
2023	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	11	3/1/2023	COMPETING CONTINUATION	$588,994
2023	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	9	3/1/2023	SUPPLEMENT FOR EXPANSION	-$48,384
2023	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	10	3/1/2023	NON-COMPETING CONTINUATION	-$540,611
														Subtotal = $1,417,851

Issue Date FY: 2022 ( Subtotal = $1,469,906 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	11	5/20/2022	COMPETING CONTINUATION	$1,469,906
2022	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	10	3/4/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,469,906

Issue Date FY: 2021 ( Subtotal = $1,941,665 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	10	7/2/2021	NON-COMPETING CONTINUATION	$1,782,165
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	9	3/10/2021	SUPPLEMENT FOR EXPANSION	$159,500
2021	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	9	2/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,941,665

Issue Date FY: 2020 ( Subtotal = $2,028,788 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	9	7/28/2020	NON-COMPETING CONTINUATION	$1,785,708
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	002	9	8/25/2020	NON-COMPETING CONTINUATION	$243,080
2020	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	8	2/20/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,028,788

Issue Date FY: 2019 ( Subtotal = $1,883,641 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	8	7/30/2019	NON-COMPETING CONTINUATION	$1,883,641
2019	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	7	2/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,883,641

Issue Date FY: 2018 ( Subtotal = $2,230,905 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	001	7	7/24/2018	NON-COMPETING CONTINUATION	$2,002,569
2018	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	6	2/6/2018	COMPETING CONTINUATION	$228,336
														Subtotal = $2,230,905

Issue Date FY: 2017 ( Subtotal = $1,884,447 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cancer Cause and Prevention Research	000	6	8/16/2017	COMPETING CONTINUATION	$1,884,447
														Subtotal = $1,884,447

Grand Total All Awards = $14,262,888

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Cancer Epidemiology Cohort in Male Health Professionals

Award Number: U01CA167552

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/21/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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