Thursday, November 21, 2024 11/21/2024

Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

Award Number: U01CA164973
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the investigators in nutrition, ethnic/racial disparities studies, and genetics. It is the most ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by significantly supplementing active follow-up information with computerized linkages to SEER cancer registries, vital statistics, hospital-discharge diagnoses, medical claim data, electronic medical records and geospatial information. At baseline, the cohort included information on 215,000 men and women, comprised almost entirely of five ethnic/racial populations: Japanese Americans, Latinos, Whites, African Americans and Native Hawaiians. The resource was later expanded to include a prospective biorepository of blood specimens from ~70,000 of the participants and urine specimens on a large subset. Leadership of the MEC entails a highly interactive, team-science approach, and the investigators have amply demonstrated their willingness to share data/samples, and to participate actively in consortia. Research accomplishments include significant contributions to understanding both genetic and environmental risk factors for cancer. Over 291 papers describing our findings have been published during the current grant cycle. In addition, over the last 28 years, 129 NIH grants/supplements have been built around the MEC (77 were active in the current cycle), and more than 136 students and postdoctoral fellows have been trained on the study. This application describes our aims over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research. We project adding 7,253 incident cancer cases in the new 5 years, to the current 48,064 cases; 2,670 of these cases will have pre-diagnostic blood samples, to be added to the current 10,957 cases. We will add 6K FFPE tumor samples to the current ~13K. In addition, this grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating lifestyle, environmental, and genetic risk factors and social determinants of health for cancer and other common chronic diseases, taking advantage of new approaches, such as dietary quality indices, exposomics, genomics, epigenomics, microbiomics, metabolomics and multilevel exposures, including spatial environment, structural racism, and climate change. The MEC will allow the testing of innovative research hypotheses aimed at ensuring that racial/ethnic health disparities are investigated and that progress in disease prevention applies to all major US racial/ethnic minorities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,395,505 )
2024	2024	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	13	8/21/2024	SUPPLEMENT FOR EXPANSION	$91,381
2024	2024	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	003	13	9/5/2024	NON-COMPETING CONTINUATION	$384,245
2024	2024	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	001	13	8/20/2024	NON-COMPETING CONTINUATION	$1,919,879
2024	2023	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	12	3/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,395,505

Issue Date FY: 2023 ( Subtotal = $2,971,613 )
2023	2023	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	004	12	8/30/2023	NON-COMPETING CONTINUATION	$2,398,162
2023	2023	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Aging Research	001	11	6/6/2023	SUPPLEMENT FOR EXPANSION	$410,244
2023	2023	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	11	6/5/2023	SUPPLEMENT FOR EXPANSION	$38,586
2023	2023	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	005	12	8/31/2023	SUPPLEMENT FOR EXPANSION	$124,621
2023	2022	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	003	11	8/24/2023	COMPETING CONTINUATION	$1,206
2023	2021	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	10	8/24/2023	NON-COMPETING CONTINUATION	-$1,206
														Subtotal = $2,971,613

Issue Date FY: 2022 ( Subtotal = $2,467,427 )
2022	2022	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	11	9/16/2022	COMPETING CONTINUATION	$2,467,427
2022	2021	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	001	10	6/17/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	10	6/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,467,427

Issue Date FY: 2021 ( Subtotal = $2,927,823 )
2021	2021	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	004	10	8/12/2021	NON-COMPETING CONTINUATION	$2,927,823
2021	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	003	9	3/19/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	9	3/8/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Trans-NIH Research Support	001	9	2/9/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	9	11/16/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,927,823

Issue Date FY: 2020 ( Subtotal = $3,813,433 )
2020	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Trans-NIH Research Support	003	9	9/1/2020	SUPPLEMENT FOR EXPANSION	$232,505
2020	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	004	9	9/2/2020	SUPPLEMENT FOR EXPANSION	$199,466
2020	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	005	9	9/11/2020	NON-COMPETING CONTINUATION	$393,758
2020	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	9	8/21/2020	NON-COMPETING CONTINUATION	$2,987,704
2020	2017	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	001	6	4/3/2020	COMPETING CONTINUATION	$1,949
2020	2016	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	5	4/3/2020	EXTENSION WITH OR WITHOUT FUNDS	-$1,949
														Subtotal = $3,813,433

Issue Date FY: 2019 ( Subtotal = $3,622,273 )
2019	2019	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	004	8	9/18/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	001	8	8/23/2019	NON-COMPETING CONTINUATION	$2,937,143
2019	2019	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	003	8	8/30/2019	NON-COMPETING CONTINUATION	$276,431
2019	2019	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	8	8/27/2019	SUPPLEMENT FOR EXPANSION	$408,699
2019	2018	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	7	2/1/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,622,273

Issue Date FY: 2018 ( Subtotal = $3,418,975 )
2018	2018	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	003	7	8/23/2018	NON-COMPETING CONTINUATION	$100,000
2018	2018	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	7	8/8/2018	NON-COMPETING CONTINUATION	$3,088,295
2018	2018	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	004	7	8/30/2018	NON-COMPETING CONTINUATION	$230,680
2018	2017	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	001	6	3/12/2018	COMPETING CONTINUATION	$7,669
2018	2016	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	5	3/12/2018	EXTENSION WITH OR WITHOUT FUNDS	-$7,669
														Subtotal = $3,418,975

Issue Date FY: 2017 ( Subtotal = $3,176,130 )
2017	2017	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	004	6	9/18/2017	COMPETING CONTINUATION	$3,176,130
2017	2016	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	001	5	2/3/2017	EXTENSION WITH OR WITHOUT FUNDS	$268,322
2017	2016	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	003	5	5/16/2017	EXTENSION WITH OR WITHOUT FUNDS	$7,640
2017	2015	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	002	4	5/16/2017	NON-COMPETING CONTINUATION	-$7,640
2017	2015	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	4	2/3/2017	NON-COMPETING CONTINUATION	-$268,322
														Subtotal = $3,176,130

Issue Date FY: 2016 ( Subtotal = $3,863,910 )
2016	2016	UNIVERSITY OF HAWAII	2530 Dole St., Sakamaki D200	HONOLULU	HI	96822	HONOLULU	USA	Cancer Cause and Prevention Research	000	5	8/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$3,863,910
														Subtotal = $3,863,910

Issue Date FY: 2015 ( Subtotal = $3,879,211 ) (Continued on the next page)
Grand Total All Awards = $32,536,300

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Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

Award Number: U01CA164973

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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