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A Lower Extremity Neuromusculoskeletal Human Simulator: Addressing Multiscale Challenges

Award Number: U01AR072989
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/07/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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A Lower Extremity Neuromusculoskeletal Human Simulator: Addressing Multiscale Challenges - PROJECT SUMMARY / ABSTRACT Our vision is to represent the human musculoskeletal system, through the creation of data and models, with the realism needed to understand pathology and improve treatment. The human body is inherently multiscale. Diseases and injuries often affect tissues at the microstructural scale; small-scale pathology impacts biomechanics at larger scales, leading to whole-body movement compensations that oftentimes promote further injury or accelerate degeneration. Ultimately, a multiscale approach, describing the behavior of individual tissues, and the biomechanics of the whole body, is needed to elucidate the etiology of diseases, mechanisms of adaptation and best treatments. The overall goal of this proposal is to create a comprehensive multiscale neuromusculoskeletal model of the human lower extremity, which includes seamless connection between tissue and whole-body function during dynamic human activities and enables realistic investigations of musculoskeletal disease and treatment. While we will create and share models with broad applicability in biomechanics, our target is understanding the effects of knee osteoarthritis (OA) on patient function and optimizing treatment through total knee arthroplasty (TKA). OA is a serious degenerative joint disease and the leading cause of disability in the elderly. Moreover, OA is interrelated with many pressing health concerns, including obesity, cardiovascular disease (CVD), Alzheimer’s disease, dementia, and depression. Joint replacement remains the only effective treatment for advanced OA. Unfortunately, as many as 20-30% of total joint replacement patients report pain, require additional surgeries, and endure a poor movement-related quality of life. A tenet of our research is the use of human modeling and simulation to investigate the multiscale effects of OA on patients, and to improve the design and practice of joint replacement surgery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	10/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	8/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $436,473 )
2021	2021	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	8/3/2021	NON-COMPETING CONTINUATION	$436,473
														Subtotal = $436,473

Issue Date FY: 2020 ( Subtotal = $449,974 )
2020	2020	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/6/2020	NON-COMPETING CONTINUATION	$449,974
														Subtotal = $449,974

Issue Date FY: 2019 ( Subtotal = $509,193 )
2019	2019	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/7/2019	NON-COMPETING CONTINUATION	$509,193
														Subtotal = $509,193

Issue Date FY: 2018 ( Subtotal = $530,668 )
2018	2018	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	9/25/2018	NEW	$84,077
2018	2018	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/8/2018	NEW	$446,591
2018	2018	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	9/10/2018	NEW	$0
														Subtotal = $530,668

Grand Total All Awards = $1,926,308

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A Lower Extremity Neuromusculoskeletal Human Simulator: Addressing Multiscale Challenges

Award Number: U01AR072989

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/07/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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