Thursday, July 31, 2025 7/31/2025

Pennington MoTrPAC Adults - Renewal

Award Number: U01AR071160
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/06/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Pennington MoTrPAC Adults - Renewal - MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The NIH that exercise initial goal set forth by was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) are andomized to endurance training ( 170 youth, 840 adults), resistance training (840 adults), or non- controls (50 youth, 300 adults). r An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite encountered (adult) and study. the numerous challenges as a result of the pandemic, the human clinical centers have successfully enrolled ~80% and 95% (pediatric) of the highly active cohort, ~93% of cross-sectional (pediatric), and ~60% (adult) ~50% (pediatric) of the current target enrollment numbers in the randomized control trial portion of the This led to the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete mechanistic highly exercise extension more activity recruitment and follow-up for the clinical studies, including finishing randomized controlled trials of sedentary adults and children and observational studies of active adults and children. This wil l enrich the articipant cohorts that are critical to understand adaptations and heterogeneity across age, gender, and minority groups. Altogether, this will allow MoTrPAC to complete the intended goals as riginally envisioned and will provide a complete public database of the health benefits of exercise and provide insight into how physical mitigates disease. p o


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2024	PENNINGTON BIOMEDICAL RESEARCH CENTER	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	8	4/11/2025	NON-COMPETING CONTINUATION	$0
2025	2023	PENNINGTON BIOMEDICAL RESEARCH CENTER	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	7	3/20/2025	COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = $602,005 )
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	009	8	9/4/2024	NON-COMPETING CONTINUATION	$0
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	008	8	8/20/2024	NON-COMPETING CONTINUATION	$602,006
2024	2023	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	007	7	8/20/2024	COMPETING CONTINUATION	$0
2024	2023	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	006	7	3/19/2024	COMPETING CONTINUATION	-$1
2024	2023	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	005	7	2/20/2024	COMPETING CONTINUATION	$5,132,341
2024	2022	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	003	6	2/20/2024	NON-COMPETING CONTINUATION	-$2,375,000
2024	2021	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	004	5	2/20/2024	SUPPLEMENT FOR EXPANSION	-$31,968
2024	2021	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	5	2/20/2024	NON-COMPETING CONTINUATION	-$2,375,000
2024	2020	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	002	4	2/20/2024	SUPPLEMENT FOR EXPANSION	-$4,966
2024	2020	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	4	2/20/2024	NON-COMPETING CONTINUATION	-$345,407
														Subtotal = $602,005

Issue Date FY: 2023 ( Subtotal = $1 )
2023	2023	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	002	7	9/21/2023	COMPETING CONTINUATION	$1
2023	2022	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	6	9/20/2023	NON-COMPETING CONTINUATION	$0
2023	2022	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	6	11/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2022 ( Subtotal = $2,375,000 )
2022	2022	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	6	12/3/2021	NON-COMPETING CONTINUATION	$2,375,000
2022	2021	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	5	4/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,375,000

Issue Date FY: 2021 ( Subtotal = $2,406,968 )
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	002	5	7/22/2021	SUPPLEMENT FOR EXPANSION	$31,968
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	5	12/18/2020	NON-COMPETING CONTINUATION	$2,375,000
2021	2020	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	4	11/19/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,406,968

Issue Date FY: 2020 ( Subtotal = $2,535,942 )
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	4	2/13/2020	NON-COMPETING CONTINUATION	$2,500,000
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	4	9/17/2020	SUPPLEMENT FOR EXPANSION	$35,942
														Subtotal = $2,535,942

Issue Date FY: 2019 ( Subtotal = $1,780,094 )
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	3	3/21/2019	NON-COMPETING CONTINUATION	$0
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	3	1/10/2019	NON-COMPETING CONTINUATION	$1,780,094
														Subtotal = $1,780,094

Issue Date FY: 2018 ( Subtotal = $1,064,745 )
2018	2018	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	2	2/21/2018	NON-COMPETING CONTINUATION	$1,064,745
														Subtotal = $1,064,745

Issue Date FY: 2017 ( Subtotal = $247,994 )
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	001	1	9/21/2017	NEW	$100,000
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Trans-NIH Research Support	000	1	12/6/2016	NEW	$147,994
														Subtotal = $247,994

Grand Total All Awards = $11,012,750

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Pennington MoTrPAC Adults - Renewal

Award Number: U01AR071160

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/06/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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