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Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

Award Number: U01AR071124
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/06/2016
PERIOD OF PERFORMANCE END DATE: 08/30/2027

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Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center - MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+ years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39, 40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	10/14/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	12/17/2024	NON-COMPETING CONTINUATION	$0
2025	2024	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	8	7/24/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	8	4/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,100,000 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	006	8	8/29/2024	NON-COMPETING CONTINUATION	$0
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	005	8	8/13/2024	NON-COMPETING CONTINUATION	$1,100,000
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	7	8/12/2024	COMPETING CONTINUATION	$0
2024	2023	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	7	6/24/2024	COMPETING CONTINUATION	$2,655,146
2024	2022	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	6	6/24/2024	NON-COMPETING CONTINUATION	-$2,517,500
2024	2021	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	002	5	6/24/2024	SUPPLEMENT FOR EXPANSION	-$2,440
2024	2021	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	5	6/24/2024	NON-COMPETING CONTINUATION	-$135,207
														Subtotal = $1,100,000

Issue Date FY: 2023 ( Subtotal = $2,000,000 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	7	9/19/2023	COMPETING CONTINUATION	$2,000,000
2023	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	6	11/28/2022	NON-COMPETING CONTINUATION	$0
2023	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	6	9/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,000,000

Issue Date FY: 2022 ( Subtotal = $2,517,500 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	6	12/6/2021	NON-COMPETING CONTINUATION	$2,517,500
														Subtotal = $2,517,500

Issue Date FY: 2021 ( Subtotal = $2,562,923 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	5	12/19/2020	NON-COMPETING CONTINUATION	$2,517,500
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	002	5	9/22/2021	SUPPLEMENT FOR EXPANSION	$45,423
2021	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	4	12/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,562,923

Issue Date FY: 2020 ( Subtotal = $2,685,941 )
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	4	9/17/2020	SUPPLEMENT FOR EXPANSION	$35,941
2020	2020	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	4	2/14/2020	NON-COMPETING CONTINUATION	$2,650,000
2020	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	3	8/31/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,685,941

Issue Date FY: 2019 ( Subtotal = $1,930,093 )
2019	2019	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	3	1/8/2019	NON-COMPETING CONTINUATION	$1,930,093
														Subtotal = $1,930,093

Issue Date FY: 2018 ( Subtotal = $1,426,665 )
2018	2018	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	2	2/21/2018	NON-COMPETING CONTINUATION	$1,426,665
														Subtotal = $1,426,665

Issue Date FY: 2017 ( Subtotal = $308,310 )
2017	2017	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	1	9/20/2017	NEW	$150,000
2017	2017	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	1	12/6/2016	NEW	$158,310
														Subtotal = $308,310

Grand Total All Awards = $14,531,432

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Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

Award Number: U01AR071124

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/06/2016

PERIOD OF PERFORMANCE END DATE: 08/30/2027

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