Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

A multiorgan microphysiological platform to discover and screen therapeutics for treating radiation induced vascular injury

Award Number: U01AI195488
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/20/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2031

Group Awards By:

View Award Description

A multiorgan microphysiological platform to discover and screen therapeutics for treating radiation induced vascular injury - Summary In the event of a nuclear or radiological catastrophe, affected individuals are exposed to a wide range of radiation doses with the extent of injury depending on the victims' distance from the epicenter, the duration of exposure, and their inherent sensitivity/resistance to ionizing radiation, amongst other factors. While the use of Neupogen, Neulasta and Entolimod to treat hematopoietic acute radiation syndrome (H-ARS) has been approved by the FDA, therapeutic approaches to the treatment of radiation-induced vascular/endothelial injury are largely supportive. Vascular/endothelial injury is a leading cause of morbidity and mortality in radiation-induced injury through damage to vascular barrier function and increased leukocyte trafficking and there are no specific pharmacologic therapies available that protect from leukocyte- mediated tissue damage. While animal models have been used to develop therapeutics for treating radiation damage, use of emerging technologies such as organ-on-chip allows for testing of these therapeutics in biomimetic environments using primary human cells. We propose to integrate our microfluidic models of blood-brain barrier (BBB), gut, and lung into a multiorgan RadChip platform that incorporates essential features for testing radiation induced vascular injury. We will characterize the impact of radiation damage on vascular endothelial cell activation, barrier integrity, transendothelial electrical resistance (TEER) and interaction with immune cells in our RadChip composed of multiple important organ-specific cell types. The signaling pathways regulating radiation-induced vascular permeability and leukocyte migration in human EC will be determined. A novel in silico model will be used to elucidate cellular processes impacted by radiation exposure and identify/validate FDA-approved drugs/compounds as potential therapeutics for treating radiation injury. This multiorgan RadChip will be used to test the efficacy of FDA approved drugs for treating radiation induced vascular injury. The specific aims of this project are to 1) Use a multiorgan platform to model radiation-induced vascular injury in humans, 2) Determine the mechanism by which radiation injury impacts immune cell-endothelial cell interaction, 3) Use a novel in silico model to determine the signaling pathways regulating radiation-induced vascular damage to repurpose FDA approved therapeutics. These studies will not only provide important mechanistic insights into the underlying pathogenesis of acute radiation syndrome but also provide a platform to identify and screen potential FDA-approved drugs/compounds for treating radiation injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $554,674 )
2026	2026	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Allergy and Infectious Diseases Research	000	1	4/21/2026	NEW	$554,674
														Subtotal = $554,674

Grand Total All Awards = $554,674

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A multiorgan microphysiological platform to discover and screen therapeutics for treating radiation induced vascular injury

Award Number: U01AI195488

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/20/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer