TB-RICC 3.0 is designed to support the Regional Prospective Observational Research
Tuberculosis (RePORT) Consortium to produce the highest quality observational and
interventional research on tuberculosis (TB), TB-HIV, and TB-COVID-19. To accomplish this
goal, TB-RICC 3.0 will: i) collaborate with RePORT Country-Network Data Centers and
Biorepositories to ensure that common data elements (CDE) of the Common Protocol and
Specimen Tracking are accessible through the Global Data Template; ii) organize and/or
strengthen select sites to participate in diagnostic studies and clinical trials; and iii) support the
RePORT Country-Networks to ensure further development of TB diagnostic laboratories, TB-
RICC 3.0 specialized laboratories, and biorepositories. Aims of TB-RICC 3.0 are: Coordinating
Center Structure and Function: develop a Leadership Group and Executive Committee; assure
effective communication internally and externally; establish a Data Hub to provide seamless data
management from collection to analysis; establish Scientific Working Groups; a Scientific Review
Committee and an Administrative Core; facilitate grant submissions to potential funders and
partners. Data Harmonization: Develop a data hub to collaborate with country-level data centers
to facilitate multiregional data workflow using the REDCap Harmonist platform and other tools;
Research: catalyze TB, TB/HIV and TB/COVID-19 research within and across RePORT Country
Networks, and with external partners; prioritize study of TB close contacts to evaluate biomarkers
predictive of progression to TB across three “omics” platforms and three continents; Capacity
Building: develop modular remote courses for capacity building in the components of TB research;
Mentor early-stage investigator (ESI) development. TB-RICC 3.0 will deliver high-impact
innovative research to advance TB Science and TB Control