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A multidisciplinary approach to study ecotypes driving transmission and pathogenesis of Visceral Leishmaniasis (VL) and Post kala-azar dermal leishmaniasis (PKDL) in Eastern Africa

Award Number: U01AI168619
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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A multidisciplinary approach to study ecotypes driving transmission and pathogenesis of Visceral Leishmaniasis (VL) and Post kala-azar dermal leishmaniasis (PKDL) in Eastern Africa - Leishmaniasis, caused by the protozoan parasite Leishmania, is a zoonotic disease endemic in the United States (US) and spreading. An increasing number of human cases of leishmaniasis are being reported from several states establishing ongoing autochthonous transmission of this infection in the US. In addition, widespread infection with Leishmania parasites has also been reported in dogs. Over 12 million people currently suffer from leishmaniasis, and approximately 2 million new cases occur each year world-wide, making it a global health problem. Importantly, leishmaniasis is commonly the main infection afflicting US military personnel deployed in endemic areas in the Middle East, Southern Europe and Latin America, and they are always at high risk of contracting this disease. The studies proposed in this TMRC seek to study the eco-epidemiology of leishmaniasis in high endemic regions to determine the factors that drive transmission and spread of infection in the community and identify potential animal reservoirs of the pathogen. As a vector-borne disease, transmission of leishmaniasis is influenced by intrinsic factors such as vector competence, longevity, and gut microbiota, and extrinsic factors including reservoir diversity, vector feeding preferences, and vector anthropophilicity. Yet, how these factors promote transmission of leishmaniasis is poorly understood. To study the epidemiology of leishmaniasis in a high transmission setting, we are: 1) mapping human exposure/infection and pathology in four endemic sites in Sudan, Kenya and Ethiopia using PCR and clinical case reports 2) determining how vector density, infection rates, and ecologic and seasonal settings influence transmission in the 4 sites and 3) using satellite images in combination with patient and vector data to generate a map of transmission risk. We are also establishing potential transmission drivers of leishmaniasis through 1) systematic collections of sand flies from suitable niches within the 4 study sites, 2) determining the infection status of collected sand flies to assess their vectorial capacity, 3) identifying the source of blood meal in the collected sand flies to establish the anthropophilicity of vector species and potential animal reservoirs. The proposed studies will generate data that are translational and applicable to other areas where leishmaniasis is endemic including the US, and as such will have a direct impact on reducing disease burden of leishmaniasis in the US in near future. Understanding the factors influencing transmission by the sand fly vector, determining how leishmaniasis infection spreads in the community, and identifying potential animals and rodents that can be reservoirs of infection will provide critical information for developing public health policies, disease surveillance and appropriate vector and reservoir control strategies in the US to prevent transmission and reduce spread of infection. Furthermore, diagnostic assays and molecular assays developed for detecting infection and for identifying animal reservoirs, respectively, will provide critical tools for vector and disease surveillance in endemic regions of the US as well as developing strategies for prevention of infection in US Service personnel deployed abroad.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $429,273 )
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	005	5	7/23/2026	NON-COMPETING CONTINUATION	$0
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	5	6/23/2026	NON-COMPETING CONTINUATION	$207,567
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	004	5	7/9/2026	SUPPLEMENT FOR EXPANSION	$75,451
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	002	5	7/7/2026	SUPPLEMENT FOR EXPANSION	$85,923
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	003	5	7/7/2026	SUPPLEMENT FOR EXPANSION	$60,332
2026	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	4	12/23/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $429,273

Issue Date FY: 2025 ( Subtotal = $431,238 )
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	4	8/27/2025	NON-COMPETING CONTINUATION	$210,577
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	003	4	8/29/2025	SUPPLEMENT FOR EXPANSION	$72,923
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	002	4	8/29/2025	SUPPLEMENT FOR EXPANSION	$60,763
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	4	8/29/2025	SUPPLEMENT FOR EXPANSION	$86,975
														Subtotal = $431,238

Issue Date FY: 2024 ( Subtotal = $433,155 )
2024	2024	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	002	3	4/18/2024	NON-COMPETING CONTINUATION	$433,155
2024	2023	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	001	2	1/30/2024	NON-COMPETING CONTINUATION	$0
2024	2022	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	1	11/1/2023	NEW	$0
														Subtotal = $433,155

Issue Date FY: 2023 ( Subtotal = $435,030 )
2023	2023	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	2	3/23/2023	NON-COMPETING CONTINUATION	$435,030
														Subtotal = $435,030

Issue Date FY: 2022 ( Subtotal = $436,865 )
2022	2022	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Allergy and Infectious Diseases Research	000	1	3/29/2022	NEW	$436,865
														Subtotal = $436,865

Grand Total All Awards = $2,165,561

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A multidisciplinary approach to study ecotypes driving transmission and pathogenesis of Visceral Leishmaniasis (VL) and Post kala-azar dermal leishmaniasis (PKDL) in Eastern Africa

Award Number: U01AI168619

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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