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Changing the Landscape of Soil Transmitted Helminth Infections in India Using a One Health Approach

Award Number: U01AI168611
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/20/2023
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Changing the Landscape of Soil Transmitted Helminth Infections in India Using a One Health Approach - PROJECT SUMMARY Soil transmitted helminths (STH) - hookworms (Ancylostoma duodenale and Necator americanus), Ascaris lumbricoides and Trichuris trichiura - are among the most widespread neglected tropical diseases (NTD) of humans worldwide, disproportionately affecting the poorest and most vulnerable communities. In rural, populations, intensive animal-human mixing with livestock and companion animals combined with poor hygiene and sanitation can lead to transmission of zoonotic infections as well as result in zoonotic sources of infection. It is estimated that 30% of households globally have domestic livestock animals, with south and southeast Asia and Africa contributing the largest proportion. These regions also have the highest burden of STH globally. Most epidemiological surveys and mathematical models of STH do not account for or measure the risk of infections acquired from zoonotic sources, either by direct contact with animals or animal feces or indirectly from the environment. The inability to interrupt transmission due to presence of zoonotic and environmental reservoirs of infection may prolong mass drug administration (MDA) campaigns and result in emergence of anthelmintic resistance. The overarching goal of this multi-disciplinary collaborative application is to use a One Health framework to examine the interconnected burden and transmission patterns between human, animal and environmental reservoirs of STH by integrating carefully collected epidemiological, environmental and qualitative research data with state-of-art molecular techniques to better inform monitoring and elimination strategies in endemic communities. We will leverage an ongoing randomized controlled trial on community wide MDA and an upcoming One Health project in two eco-epidemiologically and culturally distinct geographic regions of India (Tamil Nadu and Meghalaya) to: (1) comprehensively investigate the transmission dynamics of different STH species at individual, household and community levels; (2) ascertain the impact of community wide MDA on zoonotic STH transmission and screen for emergence of benzimidazole resistance markers; and (3) develop and validate field-ready, portable point-of-collection (POC) diagnostics for STH based on prevalent human and zoonotic species. The field and laboratory data will provide the key parameters to build species-specific STH transmission models and explore the impact of human, animal and environmental reservoirs on STH control measures, across a range of transmission scenarios. The One Health framework of this TMRC will provide much needed data for future planning of integrated STH control programs that combine community wide MDA with upgraded WASH, supported by POC molecular diagnostics. The center will provide a platform for early career investigators to conduct multi- disciplinary One Health research on STH as well as other zoonotic or helminth NTDs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $338,690 )
2026	2026	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	001	4	2/11/2026	SUPPLEMENT FOR EXPANSION	$76,988
2026	2026	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	003	4	3/2/2026	SUPPLEMENT FOR EXPANSION	$76,988
2026	2026	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	002	4	2/23/2026	SUPPLEMENT FOR EXPANSION	-$76,988
2026	2026	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	000	4	2/6/2026	NON-COMPETING CONTINUATION	$261,702
														Subtotal = $338,690

Issue Date FY: 2025 ( Subtotal = $346,893 )
2025	2025	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	000	3	4/2/2025	NON-COMPETING CONTINUATION	$346,893
														Subtotal = $346,893

Issue Date FY: 2024 ( Subtotal = $346,294 )
2024	2024	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	000	2	4/2/2024	NON-COMPETING CONTINUATION	$346,294
														Subtotal = $346,294

Issue Date FY: 2023 ( Subtotal = $347,100 )
2023	2023	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	Allergy and Infectious Diseases Research	000	1	3/20/2023	NEW	$347,100
														Subtotal = $347,100

Grand Total All Awards = $1,378,977

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Changing the Landscape of Soil Transmitted Helminth Infections in India Using a One Health Approach

Award Number: U01AI168611

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/20/2023

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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