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Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regions

Award Number: U01AI165745
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regions - ABSTRACT An effective vaccine would complement other public health measures and is likely essential for putting an end to the high burden of malaria worldwide. Unfortunately, most malaria vaccines that entered late-stage clinical development, have shown moderate efficacy in low and middle income countries. Through a number of studies vaccine efficacy was shown to vary from 20% to 100% when used in different countries and populations. Better understanding of factors that influence this variation is urgently needed. Even within a country significant differences in vaccine efficacy in rural and urban areas are present. This implies that exposure to environmental factors plays a major role besides genetic determinants. How and to what extent environmental exposures can influence immune profiles and in turn affect responses to vaccines? This question will be addressed in the current proposal. Technological advances in “omics” platforms have improved our ability to examine the immune system in a more unbiased manner. Such platforms, involving transcriptomics, are being increasingly applied to understand vaccine responses, with promising results. However, for malaria vaccines, no harmonized approach to interrogate immunological reactivities and pathways across cohorts has been developed despite its public health importance and availability of cohorts assessed for a clinically relevant outcome (prevention of infection or disease). Even less has been done regarding integrated “omics”, comparing populations living in different geographical locations and their response to vaccines. Moreover, there are very little data that link environmental exposures to in depth changes in the immune system and if available, the studies often address one environmental factor at a time. We propose to address this and not only assess correlations in malaria vaccine cohorts, but also to address the mechanisms underlying vaccine (hypo)responsiveness. We will build on available knowledge of immunological processes that can affect malaria vaccine responses, and use samples from the cohorts where high dimensional cytometry and RNASeq and antibody interrogations will help to refine and enrich the questions regarding malaria vaccine (hypo)responsiveness. In addition, by using human primary hepatocytes infected with P. falciparum, we will bring the research closer to mechanisms of tissue-specific responses and to extrapolate pre-erythrocytic immunity to malaria in the liver. This is of particular importance for pre- erythrocytic vaccines, where tissue-resident responses can play an important role. By generating data on the same individuals, data integration approaches for high dimensional mediation analysis, will be used to pinpoint the specific immunological pathways and mechanisms that result in malaria vaccine (hypo) responsiveness. This information can be used to improve malaria vaccine efficacy and also to identify individuals who will not benefit from the vaccine regimens used so far. It can direct, in an evidence based manner, alterations to the vaccination dose, intervals and adjuvants.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $650,010 )
2025	2025	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	001	4	3/21/2025	NON-COMPETING CONTINUATION	$650,010
2025	2024	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	000	3	2/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $650,010

Issue Date FY: 2024 ( Subtotal = $650,010 )
2024	2024	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	000	3	2/27/2024	NON-COMPETING CONTINUATION	$585,009
2024	2024	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	001	3	4/22/2024	NON-COMPETING CONTINUATION	$65,001
														Subtotal = $650,010

Issue Date FY: 2023 ( Subtotal = $650,010 )
2023	2023	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	002	2	9/15/2023	NON-COMPETING CONTINUATION	$0
2023	2023	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	001	2	3/30/2023	NON-COMPETING CONTINUATION	$650,010
2023	2022	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	000	1	3/29/2023	NEW	$0
														Subtotal = $650,010

Issue Date FY: 2022 ( Subtotal = $650,010 )
2022	2022	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN	ZUID-HOLLAND			NLD	Allergy and Infectious Diseases Research	000	1	3/7/2022	NEW	$483,790
2022	2022	ACADEMISCH ZIEKENHUIS LEIDEN	ALBINUSDREEF 2	LEIDEN				NLD	Allergy and Infectious Diseases Research	001	1	8/31/2022	NEW	$166,220
														Subtotal = $650,010

Grand Total All Awards = $2,600,040

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Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regions

Award Number: U01AI165745

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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