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Maximizing the success of HIV+ to HIV+ kidney transplantation in South Africa

Award Number: U01AI152153
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/06/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Maximizing the success of HIV+ to HIV+ kidney transplantation in South Africa - Project Summary: We previously demonstrated that the patient and graft survival rates for HIV+ to HIV+ kidney transplants are comparable to rates seen in other HIV+ transplant recipients. We also showed that these transplants do not result in sustained HIV superinfection despite presence of a detectable donor viral inoculum in these recipients, alleviating one of the major concerns with these surgeries. This proposal aims to expand on these novel findings by initially exploring how the immune modulators these patients receive may affect the HIV latent viral reservoir, which is the primary hurdle in the search for an HIV cure. In addition, we and others have observed a possible increased risk of rejection in HIV+ kidney transplant recipients in general. Therefore, we have partnered with the HIV transplant and pathology groups at UCSF, as well as a team of other collaborators from the US, Spain, and South Africa, to examine the role of several components of the immune response associated with organ rejection. We will also utilize this diverse team of experts in HIV infectious disease, pathology, and transplantation to increase clinical and laboratory support for transplantation services in underserved areas in South Africa, thereby increasing availability of these life- saving transplants. The results of this study will have a direct and immediate influence on transplant clinical practice in South Africa and the US. Additionally, our study provides an opportunity to answer multiple fundamental biological questions surrounding HIV cure research and HIV related organ rejection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	Allergy and Infectious Diseases Research	000	5	7/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $159,840 )
2024	2024	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	Allergy and Infectious Diseases Research	000	5	4/11/2024	NON-COMPETING CONTINUATION	$159,840
														Subtotal = $159,840

Issue Date FY: 2023 ( Subtotal = $171,428 )
2023	2023	UNIVERSITY OF CAPE TOWN	LOVERS WALK	CAPE TOWN				ZAF	Allergy and Infectious Diseases Research	000	4	5/12/2023	NON-COMPETING CONTINUATION	$171,428
														Subtotal = $171,428

Issue Date FY: 2022 ( Subtotal = $180,209 )
2022	2022	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Allergy and Infectious Diseases Research	001	3	6/29/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Allergy and Infectious Diseases Research	000	3	4/1/2022	NON-COMPETING CONTINUATION	$180,209
														Subtotal = $180,209

Issue Date FY: 2021 ( Subtotal = $189,265 )
2021	2021	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH				ZAF	Allergy and Infectious Diseases Research	000	2	3/11/2021	NON-COMPETING CONTINUATION	$189,265
														Subtotal = $189,265

Issue Date FY: 2020 ( Subtotal = $199,012 )
2020	2020	UNIVERSITY OF CAPE TOWN	LOVERS WALK	RONDEBOSCH		007700		ZAF	Allergy and Infectious Diseases Research	000	1	4/6/2020	NEW	$199,012
														Subtotal = $199,012

Grand Total All Awards = $899,754

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Maximizing the success of HIV+ to HIV+ kidney transplantation in South Africa

Award Number: U01AI152153

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/06/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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