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Understanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast Asia

Award Number: U01AI151797
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/17/2020
PERIOD OF PERFORMANCE END DATE: 05/15/2024

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Understanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast Asia - PROJECT SUMMARY/ABSTRACT Southeast Asia is one of the world’s highest-risk EID hotspots, the origin of the SARS pandemic, Nipah virus, and repeated outbreaks of influenza. This is driven by high diversity of wildlife and rapidly expanding demography that brings human and wildlife populations closer. This proposal will launch the Emerging Infectious Diseases - South East Asia Research Collaboration Hub (EID-SEARCH), a collaboration among leaders in emerging disease research in the USA, Thailand, Singapore and the 3 major Malaysian administrative regions. These researchers have networks that span >50 clinics, laboratories and research institutions across almost all SE Asian countries and will use the EID-SEARCH as an early warning system for outbreaks involving exchange of information, reagents, samples and technology, and a collaborative power- house for fundamental and translational research. The EID-SEARCH will also act as a significant asset to scale-up and deploy resources in the case of an outbreak in the region. This EIDRC will conduct research to: 1) Identify, characterize and rank spillover risk of high zoonotic potential viruses from wildlife, by analyzing previously-archived wildlife samples, conducting targeted wildlife surveillance, and using serology & PCR assays to identify novel viruses. These will be characterized to assess risk of spillover to people, and a series of in vitro (receptor binding, cell culture) and in vivo (humanized mouse and collaborative cross models) assays used to assess their potential to infect people and cause disease; 2) Collect samples and questionnaire data from human communities that live in EID hotspots and have high cultural and behavioral risk of animal exposure (e.g. wildlife hunting, bat guano collection). These will be tested with serological assays to identify evidence of novel virus spillover, and analyzed against metadata to identify key risk pathways for transmission; 3) Identify and characterize viral etiology of ‘cryptic’ outbreaks in clinical cohorts. We will conduct syndromic surveillance at clinics serving the populations in Aim 2, enroll patients with undiagnosed illness and symptoms consistent with emerging viral pathogens, and test samples with molecular and follow-up serological assays to identify causal links between these syndromes and novel viruses. This research will advance our understanding of the risk of novel viral emergence in a uniquely important region. It will also strengthen in-country research capacity by linking local infectious disease scientists with an international collaborative network that has proven capacity to conduct this work and produce significant findings. The large body of high impact collaborative research from this EIDRC leadership team provides proof-of-concept that EID-SEARCH has the background, collaborative network, experience, and skillset to act as a unique early warning system for novel EIDs of any etiology threatening to emerge in this hottest of the EID hotspots.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1,197,882 )
2025	2023	ECOHEALTH ALLIANCE INC	520 8TH AVE SUITE 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	001	4	4/11/2025	NON-COMPETING CONTINUATION	-$1,197,882
2025	2023	ECOHEALTH ALLIANCE INC	520 8TH AVE SUITE 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	000	4	3/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = -$1,197,882

Issue Date FY: 2023 ( Subtotal = $1,464,739 )
2023	2023	ECOHEALTH ALLIANCE INC.	520 8TH AVE RM 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	002	4	9/15/2023	NON-COMPETING CONTINUATION	$1,464,739
2023	2022	ECOHEALTH ALLIANCE INC.	520 8TH AVE RM 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	4/26/2023	NON-COMPETING CONTINUATION	$0
2023	2022	ECOHEALTH ALLIANCE INC.	520 8TH AVE RM 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	001	3	5/5/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,464,739

Issue Date FY: 2022 ( Subtotal = $1,504,400 )
2022	2022	ECOHEALTH ALLIANCE INC.	520 8TH AVE RM 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	001	3	9/21/2022	NON-COMPETING CONTINUATION	$1,504,400
2022	2021	ECOHEALTH ALLIANCE INC.	520 8TH AVE RM 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	2/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,504,400

Issue Date FY: 2021 ( Subtotal = $1,505,568 )
2021	2021	ECOHEALTH ALLIANCE INC.	520 8TH AVE RM 1200	NEW YORK	NY	10018	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	6/11/2021	NON-COMPETING CONTINUATION	$1,505,568
														Subtotal = $1,505,568

Issue Date FY: 2020 ( Subtotal = $1,546,744 )
2020	2020	ECOHEALTH ALLIANCE INC.	460 W 34TH ST 17TH FL	NEW YORK	NY	10001	NEW YORK	USA	Allergy and Infectious Diseases Research	001	1	8/28/2020	NEW	$0
2020	2020	ECOHEALTH ALLIANCE INC.	460 W 34TH ST 17TH FL	NEW YORK	NY	10001	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	6/17/2020	NEW	$1,546,744
														Subtotal = $1,546,744

Grand Total All Awards = $4,823,569

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Understanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast Asia

Award Number: U01AI151797

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/17/2020

PERIOD OF PERFORMANCE END DATE: 05/15/2024

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