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Inter-regional study of transmission, adaptation and pathogenesis of viruses with pandemic potential in Southeast Asia and West/Central Africa

Award Number: U01AI151758
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract We will establish an Emerging Infectious Disease Research Center in Southeast Asia and West/Central Africa with an inter-continental one health approach designed to improve the capacity to respond rapidly and effectively to outbreaks. Our proposal is built on an existing network of laboratories/epidemiologists in close contact with national healthcare systems. We will identify factors influencing emergence and transmission at the virus, vector and reservoir level, leading to epidemics in suspected spillover conditions. We will focus on high priority RNA viruses with epidemic potential in Africa (Rift Valley Fever virus (RVFV), Crimean Congo Hemorrhagic Fever Virus (CCHFV)) and in Southeast Asia (dengue virus (DENV)) as well as viruses (Disease X) identified from symptomatic surveillance or insect sampling. We will tackle problems in emerging infectious diseases by the following specific aims: 1) Enhance surveillance and detect unknown RNA viruses with potential for spillover to humans. We will implement an autonomous solar-powered mobile suitcase laboratory for rapid pathogen identification in the field. Connection to a cloud computing system will facilitate data analysis and sharing among healthcare centers and laboratories. We will survey pathogens present in insects in different ecological settings. We will develop new diagnostic tools for these viruses and conduct prevalence and behavioral studies in human populations to determine risk factors. 2) Understand transmission dynamics of endemic RNA viruses with high risk of outbreak. We will focus on RVFV and CCHFV in Senegal and Cameroun, and DENV in Cambodia. We will perform surveys in animals and humans using a more specific multiplex assay. We aim at obtaining better knowledge on prevalence, transmission dynamics, and identifying major insect vectors and animal reservoirs. 3) Understand factors influencing adaptation of RNA viruses to new hosts. We will use state of the art technology to generate and study key candidate viral mutations using cells from relevant species including humans. We will study efficacy of these viruses in infection of various strains of insects to estimate transmission risks. This aim will lead to better understanding of the adaptation of these viruses to new hosts and will help design more detection methods. Lastly, 4) Study of host adaptive immune responses to emerging infectious diseases in South-East Asia and Africa. We will increase our insight into the adaptive immune response at a single cell level and the sequence-function relationship of human antibodies generated during infectious diseases (DENV, RVFV, CCHFV) by combining sequencing at a single cell level with antibody repertoire analysis. We will study function and characterize structure at a single antibody level. We will provide novel understanding of the role of cellular immunity in DENV disease. The proposed activity will allow the implementation of infrastructure and an analysis pipeline for outbreak preparedness in areas where viruses with potential pandemic threats circulate.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,294,249 )
2023	2023	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	004	4	9/7/2023	NON-COMPETING CONTINUATION	$0
2023	2023	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	003	4	7/27/2023	NON-COMPETING CONTINUATION	$0
2023	2023	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	002	4	6/28/2023	NON-COMPETING CONTINUATION	$1,294,249
2023	2022	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	001	3	6/2/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	000	3	11/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,294,249

Issue Date FY: 2022 ( Subtotal = $1,434,524 )
2022	2022	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	002	3	8/19/2022	SUPPLEMENT FOR EXPANSION	$147,388
2022	2022	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	001	3	6/21/2022	NON-COMPETING CONTINUATION	$1,287,136
2022	2021	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	000	2	5/27/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,434,524

Issue Date FY: 2021 ( Subtotal = $1,667,740 )
2021	2021	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	000	2	6/14/2021	NON-COMPETING CONTINUATION	$1,213,204
2021	2021	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS				FRA	Allergy and Infectious Diseases Research	001	2	8/31/2021	SUPPLEMENT FOR EXPANSION	$454,536
														Subtotal = $1,667,740

Issue Date FY: 2020 ( Subtotal = $1,186,205 )
2020	2020	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	001	1	9/10/2020	NEW	$0
2020	2020	INSTITUT PASTEUR	28 RUE DU DOCTEUR ROUX	PARIS		75015		FRA	Allergy and Infectious Diseases Research	000	1	7/17/2020	NEW	$1,186,205
														Subtotal = $1,186,205

Grand Total All Awards = $5,582,718

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Inter-regional study of transmission, adaptation and pathogenesis of viruses with pandemic potential in Southeast Asia and West/Central Africa

Award Number: U01AI151758

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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